{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:28:09Z","timestamp":1793082489070,"version":"4.5.0"},"reference-count":41,"publisher":"Walter de Gruyter GmbH","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2026-0320_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Therapeutic drug monitoring (TDM) of tacrolimus is essential due to its high inter- and intra-patient variability and narrow therapeutic window. Conventional venous blood sampling may limit sampling frequency and patient convenience. Capillary dried blood spot (DBS) sampling represents a patient-centric alternative that could enable decentralized monitoring and longitudinal follow-up in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0320_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to evaluate the clinical applicability of capillary finger prick sampling for tacrolimus TDM and creatinine determination in the hospital (part 1), and at home (part 2), using conventional DBS and Capitainer\n                      <jats:sup>\u00ae<\/jats:sup>\n                      qDBS devices. Previously validated liquid chromatography-tandem mass spectrometry (LC-MS\/MS) analysis methods were used. Additionally, sample quality and patient experience were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0320_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The assisted sampling part of the study revealed the clinical applicability of conventional DBS and Capitainer\n                      <jats:sup>\u00ae<\/jats:sup>\n                      qDBS sampling as a complementary tool for tacrolimus TDM and creatinine determination after capillary finger prick, with Capitainer\n                      <jats:sup>\u00ae<\/jats:sup>\n                      qDBS showing better clinical agreement (93\u202f% of tacrolimus and 87\u202f% of creatinine results within 15\u202f% of the mean). Home sampling using Capitainer\n                      <jats:sup>\u00ae<\/jats:sup>\n                      qDBS devices was found to be feasible in allo-SCT patients, who also positively scored the user-friendliness of the device.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0320_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Capillary qDBS show great potential as a complement to venous blood draws for tacrolimus and creatinine determination in TDM workflows. Integration of home-based sampling allows better longitudinal assessment of drug exposure and renal function, providing laboratory insight into intra-patient variability and adherence, contributing to more informed, individualized\u00a0TDM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2026-0320","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:02:16Z","timestamp":1778688136000},"page":"2286-2296","source":"Crossref","is-referenced-by-count":3,"title":["Patient-centric capillary dried blood spot sampling for tacrolimus and creatinine monitoring in clinical practice"],"prefix":"10.1515","volume":"64","author":[{"given":"Hanna","family":"De Baets","sequence":"first","affiliation":[{"name":"Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Laboratory of Toxicology , Ghent University , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Deprez","sequence":"additional","affiliation":[{"name":"Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Laboratory of Toxicology , Ghent University , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Delie","sequence":"additional","affiliation":[{"name":"Department of Hematology , Ghent University Hospital , Ghent , Belgium"},{"name":"Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences , Ghent University , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Kerre","sequence":"additional","affiliation":[{"name":"Department of Hematology , Ghent University Hospital , Ghent , Belgium"},{"name":"Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences , Ghent University , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-348X","authenticated-orcid":false,"given":"Christophe P.","family":"Stove","sequence":"additional","affiliation":[{"name":"Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Laboratory of Toxicology , Ghent University , Ghent , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"2026082718023513669_j_cclm-2026-0320_ref_001","doi-asserted-by":"crossref","unstructured":"Shrestha, BM. Two decades of tacrolimus in renal transplant: basic science and clinical evidences. Exp Clin Transplant 2017;15:1\u20139. https:\/\/doi.org\/10.6002\/ect.2016.0157.","DOI":"10.6002\/ect.2016.0157"},{"key":"2026082718023513669_j_cclm-2026-0320_ref_002","unstructured":"Ghent University Hospital. Stamceltransplantatie; 2022. https:\/\/www.uzgent.be\/patient\/zoek-een-arts-of-dienst\/hematologie\/stamceltransplantatieprogramma\/stamceltransplantatie [Accessed 15 December 2024]."},{"key":"2026082718023513669_j_cclm-2026-0320_ref_003","unstructured":"Erasmus, MC. Vademecum hematologie: stamceltransplantatie; 2023. https:\/\/www.vademecumhematologie.nl\/artikelen\/hemato-oncologie\/stamceltransplantatie\/ [Accessed 15 December 2024]."},{"key":"2026082718023513669_j_cclm-2026-0320_ref_004","unstructured":"Eurostat. 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Clinical validation of simultaneous analysis of tacrolimus, cyclosporine A, and creatinine in dried blood spots in kidney transplant patients. Transplantation 2017;101:1727\u201333. https:\/\/doi.org\/10.1097\/tp.0000000000001591.","DOI":"10.1097\/TP.0000000000001591"},{"key":"2026082718023513669_j_cclm-2026-0320_ref_025","doi-asserted-by":"crossref","unstructured":"Vethe, NT, Gustavsen, MT, Midtvedt, K, Lauritsen, ME, Andersen, AM, \u00c5sberg, A, et al.. Tacrolimus can be reliably measured with volumetric absorptive capillary microsampling throughout the dose interval in renal transplant recipients. Ther Drug Monit 2019;41:607\u201314. https:\/\/doi.org\/10.1097\/ftd.0000000000000655.","DOI":"10.1097\/FTD.0000000000000655"},{"key":"2026082718023513669_j_cclm-2026-0320_ref_026","doi-asserted-by":"crossref","unstructured":"Zwart, TC, Metscher, E, van der Boog, PJM, Swen, JJ, de Fijter, JW, Guchelaar, HJ, et al.. 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