{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:15:51Z","timestamp":1788196551814,"version":"build-2803163510"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2026-0333_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In vitro<\/jats:italic>\n                      serum potassium is affected by ambient temperature with peaks in the winter and troughs in the summer. We investigated whether primary care phlebotomy locations with higher winter hyperkalaemia rates exhibited higher summer hypokalaemia and evaluated a simple screening metric to identify high-risk locations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0333_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective audit of Indexor-tracked primary care potassium results analysed at a UK hub laboratory between 1 July 2024 and 30 June 2025 was performed. Bivariate multilevel logistic regression modelling assessed whether locations with higher hyperkalaemia rates in January 2025 (coldest month) also showed higher hypokalaemia rates in June 2025 (warmest month). Locations were ranked by January hyperkalaemia frequency and analysed by quartiles. ROC analysis assessed the performance of \u0394K (difference in winter and summer mean potassium) in identifying highest seasonal dyskalaemia locations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0333_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 382,735 included results, serum potassium was inversely associated with ambient temperature. Hyperkalaemia was 5.24\u202f% in January 2025 vs. 0.90\u202f% in June 2025, while hypokalaemia was 0.39\u202f% vs. 2.22\u202f%, respectively. Location-level propensities for January hyperkalaemia and June hypokalaemia correlated positively (\u03c1=0.35; 95\u202f% CrI 0.02\u20130.62). The highest-risk quartile locations had greater winter hyperkalaemia (11.44\u202f% vs. 2.97\u202f%; OR 4.22) and summer hypokalaemia (3.12\u202f% vs. 1.51\u202f%; OR 2.10) compared with the lowest quartile. \u0394K discriminated top-quartile risk locations (AUC 0.918 for winter hyperkalaemia), with an optimal threshold \u0394K\u22480.40\u202fmmol\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0333_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Phlebotomy locations prone to winter hyperkalaemia also exhibit summer hypokalaemia, reflecting location-specific pre-analytical vulnerabilities. A simple \u0394K screen can help targeted mitigation for seasonal dyskalaemia such as on-site centrifugation or transport optimisation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2026-0333","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:55:41Z","timestamp":1788195341000},"source":"Crossref","is-referenced-by-count":0,"title":["Correlated seasonal dyskalaemia in a primary care population: winter hyperkalaemia and summer hypokalaemia"],"prefix":"10.1515","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0468-5679","authenticated-orcid":false,"given":"Amro","family":"Maarouf","sequence":"first","affiliation":[{"name":"Blood Sciences, Black Country Pathology Services, The Royal Wolverhampton NHS Trust , Wolverhampton , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Danks","sequence":"additional","affiliation":[{"name":"Blood Sciences, Black Country Pathology Services, The Royal Wolverhampton NHS Trust , Wolverhampton , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Fenn","sequence":"additional","affiliation":[{"name":"Blood Sciences, Black Country Pathology Services, The Royal Wolverhampton NHS Trust , Wolverhampton , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rousseau","family":"Gama","sequence":"additional","affiliation":[{"name":"Blood Sciences, Black Country Pathology Services, The Royal Wolverhampton NHS Trust , Wolverhampton , UK"},{"name":"School of Medicine and Clinical Practice, University of Wolverhampton , Wolverhampton , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1306-8832","authenticated-orcid":false,"given":"Tejas","family":"Kalaria","sequence":"additional","affiliation":[{"name":"Blood Sciences, Black Country Pathology Services, The Royal Wolverhampton NHS Trust , Wolverhampton , UK"},{"name":"School of Medicine and Clinical Practice, University of Wolverhampton , Wolverhampton , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"2026083116553492103_j_cclm-2026-0333_ref_001","doi-asserted-by":"crossref","unstructured":"Koyama, T, Makinouchi, R, Machida, S, Matsui, K, Shibagaki, Y, Imai, N. 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Ann Clin Biochem 2012;49:94\u20136. https:\/\/doi.org\/10.1258\/acb.2011.011122.","DOI":"10.1258\/acb.2011.011122"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_004","doi-asserted-by":"crossref","unstructured":"Sinclair, D, Briston, P, Young, R, Pepin, N. Seasonal pseudohyperkalaemia. J\u00a0Clin Pathol 2003;56:385\u20138. https:\/\/doi.org\/10.1136\/jcp.56.5.385.","DOI":"10.1136\/jcp.56.5.385"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_005","doi-asserted-by":"crossref","unstructured":"Thayakaran, R, Hotham, R, Gokhale, KM, Adderley, NJ, Chandan, JS, Nirantharakumar, K. Seasonal variation of serum potassium and related prescription pattern: an ecological time series. J\u00a0Clin Pathol 2024;77:663\u20138. https:\/\/doi.org\/10.1136\/jcp-2023-208759.","DOI":"10.1136\/jcp-2023-208759"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_006","doi-asserted-by":"crossref","unstructured":"Sodi, R, Davison, AS, Holmes, E, Hine, TJ, Roberts, NB. The phenomenon of seasonal pseudohypokalemia: effects of ambient temperature, plasma glucose and role for sodium-potassium-exchanging-ATPase. Clin Biochem 2009;42:813\u20138. https:\/\/doi.org\/10.1016\/j.clinbiochem.2009.01.024.","DOI":"10.1016\/j.clinbiochem.2009.01.024"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_007","doi-asserted-by":"crossref","unstructured":"Masters, PW, Lawson, N, Marenah, CB, Maile, LJ. High ambient temperature: a spurious cause of hypokalaemia. BMJ 1996;312:1652\u20133. https:\/\/doi.org\/10.1136\/bmj.312.7047.1652.","DOI":"10.1136\/bmj.312.7047.1652"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_008","doi-asserted-by":"crossref","unstructured":"Jones, KL, Zouwail, S. High ambient temperatures and hypokalaemia. Ann Clin Biochem 2014;51:114\u20135. https:\/\/doi.org\/10.1177\/0004563213508095.","DOI":"10.1177\/0004563213508095"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_009","doi-asserted-by":"crossref","unstructured":"Kuwano, K, Shimizu, S, Fujita, Y, Akatsu, S, Shibagaki, Y, Yazawa, M. Marked hyperkalemia due to inappropriate blood sample storage in two suspected cases of familial pseudohyperkalemia. CEN Case Rep 2023;12:397\u2013401. https:\/\/doi.org\/10.1007\/s13730-023-00781-y.","DOI":"10.1007\/s13730-023-00781-y"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_010","doi-asserted-by":"crossref","unstructured":"Tanner, M, Kent, N, Smith, B, Fletcher, S, Lewer, M. Stability of common biochemical analytes in serum gel tubes subjected to various storage temperatures and times pre-centrifugation. Ann Clin Biochem 2008;45:375\u20139. https:\/\/doi.org\/10.1258\/acb.2007.007183.","DOI":"10.1258\/acb.2007.007183"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_011","doi-asserted-by":"crossref","unstructured":"Takaki, R, Kohatsu, K, Kuwano, K, Yazawa, M. Hyperkalemia presentation at a clinic during the cold season. CEN Case Rep 2025;14:34\u20138. https:\/\/doi.org\/10.1007\/s13730-024-00902-1.","DOI":"10.1007\/s13730-024-00902-1"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_012","doi-asserted-by":"crossref","unstructured":"Seamark, D, Backhouse, S, Barber, P, Hichens, J, Salzmann, M, Powell, R. Transport and temperature effects on measurement of serum and plasma potassium. J\u00a0R Soc Med 1999;92:339\u201341. https:\/\/doi.org\/10.1177\/014107689909200703.","DOI":"10.1177\/014107689909200703"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_013","unstructured":"NHS England and NHS Improvement. Pathology networking in England: state of the nation. 2019 [Online]. Available from: www.england.nhs.uk\/wp-content\/uploads\/2021\/05\/pathology-networking-state-of-the-nation-2019.pdf."},{"key":"2026083116553492103_j_cclm-2026-0333_ref_014","doi-asserted-by":"crossref","unstructured":"Einhorn, LM, Zhan, M, Hsu, VD, Walker, LD, Moen, MF, Seliger, SL, et al.. The frequency of hyperkalemia and its significance in chronic kidney disease. Arch Intern Med 2009;169:1156\u201362. https:\/\/doi.org\/10.1001\/archinternmed.2009.132.","DOI":"10.1001\/archinternmed.2009.132"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_015","doi-asserted-by":"crossref","unstructured":"Dimeski, G, Barnett, RJ. Effects of total plasma protein concentration on plasma sodium, potassium and chloride measurements by an indirect ion selective electrode measuring system. Crit Care Resusc 2005;7:12\u20135. https:\/\/doi.org\/10.1016\/s1441-2772(23)01564-8.","DOI":"10.1016\/S1441-2772(23)01564-8"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_016","doi-asserted-by":"crossref","unstructured":"Dibbern, ME, Pierre, CC, Wiencek, JR. Outdoor courier lockboxes in summer are a significant source of preanalytical error. Am J Clin Pathol 2021;156:866\u201370. https:\/\/doi.org\/10.1093\/ajcp\/aqab037.","DOI":"10.1093\/ajcp\/aqab037"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_017","doi-asserted-by":"crossref","unstructured":"Truijens, K, Frans, G, Vermeersch, P. Critical results in laboratory medicine. Clin Chem 2024;70:1220\u201330. https:\/\/doi.org\/10.1093\/clinchem\/hvae120.","DOI":"10.1093\/clinchem\/hvae120"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_018","doi-asserted-by":"crossref","unstructured":"Hunter, RW, Bailey, MA. Hyperkalemia: pathophysiology, risk factors and consequences. Nephrol Dial Transplant 2019;34:iii2\u201311. https:\/\/doi.org\/10.1093\/ndt\/gfz206.","DOI":"10.1093\/ndt\/gfz206"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_019","doi-asserted-by":"crossref","unstructured":"Weiner, ID, Wingo, CS. Hypokalemia\u00a0\u2013\u00a0consequences, causes, and correction. J\u00a0Am Soc Nephrol 1997;8:1179\u201388. https:\/\/doi.org\/10.1681\/asn.v871179.","DOI":"10.1681\/ASN.V871179"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_020","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Handling, Transport, Processing, and Storage of Blood Specimens for Routine Laboratory Examinations. CLSI document PRE04 Ed1; 2023."},{"key":"2026083116553492103_j_cclm-2026-0333_ref_021","doi-asserted-by":"crossref","unstructured":"Turner, HE, Peake, RW, Allison, JJ. The impact of centrifugation in primary care on pseudohyperkalaemia: a retrospective evaluation. Ann Clin Biochem 2013;50:371\u20133. https:\/\/doi.org\/10.1177\/0004563212474566.","DOI":"10.1177\/0004563212474566"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_022","unstructured":"Coffey, W, Magee, B, Harris, J, Edwards, R, McKillop, D. Centrifugation in GP practices\u00a0\u2013\u00a0can it improve diagnostic efficiency? Ulst Med J 2018;87:52\u20133."},{"key":"2026083116553492103_j_cclm-2026-0333_ref_023","doi-asserted-by":"crossref","unstructured":"Smellie, WS. Spurious hyperkalaemia. BMJ 2007;334:693\u20135. https:\/\/doi.org\/10.1136\/bmj.39119.607986.47.","DOI":"10.1136\/bmj.39119.607986.47"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_024","doi-asserted-by":"crossref","unstructured":"van Balveren, JA, Huijskens, MJ, Gemen, EF, P\u00e9qu\u00e9riaux, NC, Kusters, R. Effects of time and temperature on 48 routine chemistry, haematology and coagulation analytes in whole blood samples. Ann Clin Biochem 2017;54:448\u201362. https:\/\/doi.org\/10.1177\/0004563216665868.","DOI":"10.1177\/0004563216665868"},{"key":"2026083116553492103_j_cclm-2026-0333_ref_025","doi-asserted-by":"crossref","unstructured":"Wang, J, Jin, M, Zheng, J, Chen, Y, Sun, T, Zheng, Y, et al.. Sociodemographic and clinical factors influencing serum potassium concentration: a retrospective cohort study. 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