{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:03:15Z","timestamp":1787893395744,"version":"build-2784847793"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"10","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Laboratory Medicine, University Hospital of North Norway and the Norwegian Society for Medical Biochemistry"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2026-0464_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Accurate estimation of glomerular filtration rate (eGFR) is necessary for early detection and staging of chronic kidney disease (CKD), risk stratification, and guiding therapies that prevent complications and progression to advanced CKD. This study aimed to evaluate the performance of different eGFR equations in a large national cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0464_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre study was conducted at six university hospitals in Norway. Retrospective data from patient\u2019s medical records from 2005 to 2024 for 5,552 adults and 2,981 children were used to validate several creatinine-based eGFR equations against measured GFR (mGFR) by Iohexol clearance. Performance was assessed using median bias and P30 accuracy (proportion of eGFR within \u00b130\u202f% of mGFR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0464_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The European Kidney Function Consortium (EKFC) creatinine-based eGFR equation outperformed the CKD-EPI 2009 and 2021, the Modification of Diet in Renal Disease (MDRD) in adults, the Schwarts bedside and the CKiD U25 equations in children\u00a0\u22652\u00a0years and was comparable to the Lund-Malm\u00f6 equation (LM) in adults. Both CKD-EPI equations had the lowest accuracy and were overestimating GFR in young people (&lt;25 years) and elderly patients (\u226565 years). Replacing the CKD-EPI equations with the EKFC equation will result in lower eGFR values and a higher prevalence of CKD stages 3\u20135. Replacing the LM and MDRD with the EKFC equation will result in higher eGFR and a lower prevalence of CKD stages 3\u20135.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0464_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The EKFC equation was overall the best suited creatinine-based eGFR equation for this Norwegian population from 2\u00a0years of age. Clinicians should be informed about clinical implications of shifting from other equations to the EKFC equation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2026-0464","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:55:52Z","timestamp":1782363352000},"page":"2207-2215","source":"Crossref","is-referenced-by-count":1,"title":["Performance of the European Kidney Function Consortium (EKFC) creatinine-based eGFR equation and other eGFR equations in a north European population. A multicentre study in Norway"],"prefix":"10.1515","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0195-1871","authenticated-orcid":false,"given":"Maria","family":"Averina","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine , University Hospital of North Norway (UNN) , Troms\u00f8 , Norway"},{"name":"Department of Clinical Medicine, Faculty of Health Sciences , UiT, The Arctic University of Norway , Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atle","family":"Brun","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Pharmacology , Haukeland University Hospital , Bergen , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind","family":"Skadberg","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Biochemistry , Stavanger University Hospital , Stavanger , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"L\u00f8fblad","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Laboratory Clinic , St. Olavs Hospital , Trondheim , Norway"},{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences , Norwegian University of Science and Technology (NTNU) , Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Michaelsen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , University Hospital of North Norway (UNN) , Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein","family":"Bergan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Oslo University Hospital , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"\u00c5sberg","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine, Division of Surgery and Specialized Medicine , Oslo University Hospital, Rikshospitalet , Oslo , Norway"},{"name":"Department of Pharmacy , University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads Roald","family":"Lien","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Laboratory Medicine Clinic , Oslo University Hospital , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toralf","family":"Melsom","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health Sciences , UiT, The Arctic University of Norway , Troms\u00f8 , Norway"},{"name":"Department of Nephrology , University Hospital of North Norway (UNN) , Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivar Anders","family":"Eide","sequence":"additional","affiliation":[{"name":"Department of Kidney Medicine , Akershus University Hospital , Oslo , Norway"},{"name":"Division of Medicine and Laboratory Sciences , University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Morten","family":"Keil","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine , St. Olavs Hospital , Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rannveig","family":"Skrunes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Nephrology , Haukeland University Hospital , Bergen , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnhild Veline","family":"Nome","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Laboratory Medicine Clinic , Oslo University Hospital , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils Tore","family":"Vethe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Oslo University Hospital , Oslo , Norway"},{"name":"Department of Pharmacy , University of Oslo , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindhya","family":"Sithiravel","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , Akershus University Hospital , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"2026082718023512056_j_cclm-2026-0464_ref_001","doi-asserted-by":"crossref","unstructured":"Collaboration, GBDCKD. 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