{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T11:28:04Z","timestamp":1793618884889,"version":"4.5.0"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2026-0570_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Emerging lung cancer screening in smokers may offer an opportunity for simultaneous cardiovascular risk evaluation. We developed a mobile CT screening unit and assessed the feasibility of integrating dyslipidemia screening and non-HDL cholesterol-based SCORE2 estimation using the Cobas\n                      <jats:sup>\u00ae<\/jats:sup>\n                      b101 point-of-care testing (POCT) analyzer on capillary blood samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0570_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Following a preliminary evaluation of two POCT analyzers, the Cobas\n                      <jats:sup>\u00ae<\/jats:sup>\n                      b101 was selected for capillary lipid profiling. Lipid results obtained from capillary samples analyzed in the mobile unit were compared with venous samples analyzed in the central laboratory in 84 screened participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0570_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For total cholesterol and HDL-C, the Passing\u2013Bablok regression were strong, with clinically acceptable differences of\u00a0\u22120.81\u202f% and +5.23\u202f%, respectively. Triglycerides showed a clinically unacceptable difference of +29.4\u202f%, but strong agreement with clinical categories was observed (kappa 95\u202f% CI [0.55; 0.82]); this may reflect both matrix effects and the non-fasting status of almost all participants (\u223c91\u202f% were non-fasting). Calculated LDL-C misclassification rates were 47\u202f%, 37\u202f%, and 32\u202f% using the Friedewald, Sampson, and Martin\u2013Hopkins equations, respectively. Non-HDL-C showed a clinically acceptable bias of\u00a0\u22122.83\u202f%, supporting its use for prevention goals and familial hypercholesterolemia screening. Concordance analysis of SCORE2 based on non-HDL-C categories revealed high reliability (95\u202f% CI [0.72; 0.92]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0570_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings support the use of Cobas\n                      <jats:sup>\u00ae<\/jats:sup>\n                      b101 with capillary sampling for population-level screening and preliminary CVD risk assessment using SCORE2, despite reduced analytical performance for TG. Abnormal results should be confirmed by a fasting lipid profile.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2026-0570","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:55:37Z","timestamp":1785164137000},"page":"2773-2783","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating Cobas\n                    <sup>\u00ae<\/sup>\n                    b101 for lipid profile and SCORE2 risk assessment from capillary blood in population screening"],"prefix":"10.1515","volume":"64","author":[{"given":"Antoine","family":"Villemin","sequence":"first","affiliation":[{"name":"Service de Biochimie et Biologie Mol\u00e9culaire, Laboratoire de Biologie M\u00e9dicale Multisites, Hospices Civils de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Zaepfel","sequence":"additional","affiliation":[{"name":"Service de Biochimie et Biologie Mol\u00e9culaire, Laboratoire de Biologie M\u00e9dicale Multisites, Hospices Civils de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihsane","family":"Benlyamani","sequence":"additional","affiliation":[{"name":"Service de Biochimie et Biologie Mol\u00e9culaire, Laboratoire de Biologie M\u00e9dicale Multisites, Hospices Civils de Lyon , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Neugnot","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et oncologie thoracique, H\u00f4pital Lyon Sud, Hospices Civils de Lyon , Pierre B\u00e9nite , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Grolleau","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et oncologie thoracique, H\u00f4pital Lyon Sud, Hospices Civils de Lyon , Pierre B\u00e9nite , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"De Bermont","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et oncologie thoracique, H\u00f4pital Lyon Sud, Hospices Civils de Lyon , Pierre B\u00e9nite , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Pesenti","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et oncologie thoracique, H\u00f4pital Lyon Sud, Hospices Civils de Lyon , Pierre B\u00e9nite , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre Yves","family":"Courand","sequence":"additional","affiliation":[{"name":"Institut de Cardiologie, Hospices Civils de Lyon , Lyon , France"},{"name":"CREATIS, CNRS UMR5220, INSERM U1044, INSA-Lyon, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon , Lyon , France"},{"name":"F\u00e9d\u00e9ration de Cardiologie, H\u00f4pital de La Croix-Rousse Et Lyon Sud , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriane","family":"Marmontel","sequence":"additional","affiliation":[{"name":"Service de Biochimie et Biologie Mol\u00e9culaire, Laboratoire de Biologie M\u00e9dicale Multisites, Hospices Civils de Lyon , Bron , France"},{"name":"Universit\u00e9 Lyon1, INSERM, INRAE, CarMeN , Pierre B\u00e9nite , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sybil","family":"Charri\u00e8re","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon1, INSERM, INRAE, CarMeN , Pierre B\u00e9nite , France"},{"name":"Hospices Civils de Lyon, F\u00e9d\u00e9ration d\u2019Endocrinologie, Maladies M\u00e9taboliques, Diab\u00e8te et Nutrition, H\u00f4pital Louis Pradel , Bron , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Moulin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon1, INSERM, INRAE, CarMeN , Pierre B\u00e9nite , 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The effect of a comprehensive lifestyle intervention on cardiovascular risk factors in pharmacologically treated patients with stable cardiovascular disease compared to usual care: a randomised controlled trial. BMC Cardiovasc Disord 2012;12:71. https:\/\/doi.org\/10.1186\/1471-2261-12-71.","DOI":"10.1186\/1471-2261-12-71"},{"key":"2026110211032890988_j_cclm-2026-0570_ref_004","doi-asserted-by":"crossref","unstructured":"Bonney, A, Malouf, R, Marchal, C, Manners, D, Fong, KM, Marshall, HM, et al.. Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality. Cochrane Lung Cancer Group. Cochrane Database Syst Rev 2022:2022. https:\/\/doi.org\/10.1002\/14651858.CD013829.pub2.","DOI":"10.1002\/14651858.CD013829.pub2"},{"key":"2026110211032890988_j_cclm-2026-0570_ref_005","doi-asserted-by":"crossref","unstructured":"Lee, RW, Nair, A, Balata, H, Graham, C, Parylo, C, Abell, J, et al.. 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