{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T11:28:15Z","timestamp":1793618895225,"version":"4.5.0"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2026-0671_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Capillary blood sampling enables minimally invasive testing and decentralized workflows, but interchangeability with venous specimens may depend on collection site, device, and matrix.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0671_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a single-center, paired clinical study of 480 adults yielding 960 capillary specimens (fingertip lancet and upper-arm microneedle device) together with matched venous samples. We evaluated three capillary matrices (serum, heparin plasma, K\n                      <jats:sub>2<\/jats:sub>\n                      EDTA plasma). Routine analytes (n=18) spanning lipid, kidney, thyroid, and cardiac panels were measured on a single integrated platform (Cobas\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Pro c503\/e801\/ISE). HIL (hemolysis, icterus, lipemia) indices governed sample acceptance. Method comparability followed Clinical and Laboratory Standards Institute (CLSI) EP09 and EP35 and clinical relevance was assessed using the desirable total allowable error (TEa) specifications from the EFLM Biological Variation Database.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0671_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Capillary and venous results were clinically comparable for 16\/18 analytes when specified HIL cutoffs were applied, although potassium and chloride showed limited interchangeability. Agreement was strong for most measurands across matrices and sites; small, collection site-dependent offsets were observed for selected analytes (e.g., albumin [method-dependent], creatinine [method-dependent], triglycerides, C-reactive protein (CRP), N-terminal pro B-type natriuretic peptide (NT-proBNP), HDL-cholesterol) yet remained within TEa. Fingertip collections yielded larger volumes and fewer collection failures than TAP Micro Select but showed higher hemolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-0671_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Under routine acceptance criteria, capillary testing demonstrates acceptable performance for most clinical chemistry analytes across matrices. For potassium and chloride, device- and collection-site\u2013related effects warrant further evaluation. This protocol integrates collection-site and matrix assessment and constitutes one of the largest evaluations of venous\u2013capillary interchangeability and supports adoption of decentralized testing workflows.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2026-0671","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:55:43Z","timestamp":1784037343000},"page":"2757-2772","source":"Crossref","is-referenced-by-count":1,"title":["Venous-capillary blood agreement for routine chemistry analytes: effects of collection site and sample matrix"],"prefix":"10.1515","volume":"64","author":[{"given":"Sara","family":"Deza","sequence":"first","affiliation":[{"name":"Cl\u00ednica Universidad de Navarra , Pamplona , Navarra , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Fern\u00e1ndez-Montero","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine , University of Navarra , Pamplona , Navarra , Spain"},{"name":"IdiSNA, Navarra Institute for Health Research , Pamplona , Navarra , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Calleja","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universidad de Navarra , Pamplona , Navarra , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Zabalza","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universidad de Navarra , Pamplona , Navarra , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Arias","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universidad de Navarra , Pamplona , Navarra , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universidad de Navarra , Pamplona , Navarra , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Orbegozo","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universidad de Navarra , Pamplona , Navarra , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fischer","sequence":"additional","affiliation":[{"name":"Roche Diagnostics GmbH , Penzberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Engelmann-Wadin","sequence":"additional","affiliation":[{"name":"Roche Diagnostics GmbH , Penzberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Blumhardt","sequence":"additional","affiliation":[{"name":"Roche Diagnostics GmbH , Penzberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2362-9472","authenticated-orcid":false,"given":"Nerea","family":"Varo","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universidad de Navarra , Pamplona , Navarra , Spain"},{"name":"IdiSNA, Navarra Institute for Health Research , Pamplona , Navarra , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1423-273X","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universidad de Navarra , Pamplona , Navarra , Spain"},{"name":"IdiSNA, Navarra Institute for Health Research , Pamplona , Navarra , Spain"},{"name":"Service of Biochemistry , Cancer Center Cl\u00ednica Universidad de Navarra , Pamplona , Navarra , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2026110211032913256_j_cclm-2026-0671_ref_001","doi-asserted-by":"crossref","unstructured":"Gonzalez, A, Deza, S, Maroto-Garcia, J, Varo, N. 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