{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:48:20Z","timestamp":1792151300353,"version":"4.4.0"},"reference-count":45,"publisher":"Walter de Gruyter GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_cclm-2026-1382_abs_001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In hemostasis diagnostics, increasing analytical performance and test availability do not automatically translate into improved clinical outcomes. We propose value-based hemostasis diagnostics (VBHD) as a structured framework that links laboratory testing directly with patient-centered value and optimized resource utilization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-1382_abs_002\">\n                    <jats:title>Content<\/jats:title>\n                    <jats:p>VBHD extends traditional appropriateness by considering five interconnected pillars: clinical relevance, analytical excellence, expert interpretation, diagnostic stewardship, and patient-centered value. This framework shifts the hemostasis laboratory\u2019s role from a passive testing service to an active clinical consultation partner. In this model, the laboratory consultant supports clinicians across the entire testing pathway\u00a0\u2013\u00a0pre-analytical, interpretative, and post-analytical\u00a0\u2013\u00a0helping translate complex results into actionable clinical actions. We discuss the clinical and economic implications of VBHD through practical hemostasis examples, including routine preoperative aPTT screening, VTE exclusion with D-dimer, inherited thrombophilia screening before combined oral contraceptive prescription, and steady-state DOAC measurement. We also present a Clinical Value Matrix to guide resource allocation and test prioritization based on clinical impact and diagnostic complexity, as well as a comprehensive ecosystem model mapping stakeholders, enablers, and system-level outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_cclm-2026-1382_abs_003\">\n                    <jats:title>Summary and outlook<\/jats:title>\n                    <jats:p>Moving from test-centered testing to decision-centered laboratory consultation can significantly reduce waste and avoidable harm while improving care quality. Evaluating the impact of VBHD requires a multi-level strategy spanning laboratory processes, diagnostic performance, clinical safety, and healthcare system efficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/cclm-2026-1382","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:57:51Z","timestamp":1792148271000},"source":"Crossref","is-referenced-by-count":0,"title":["Value-based hemostasis diagnostics: from laboratory information to clinical value"],"prefix":"10.1515","author":[{"given":"Valeria","family":"Coluccio","sequence":"first","affiliation":[{"name":"Hematology Unit , Azienda Ospedaliero-Universitaria , Modena , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cordella","sequence":"additional","affiliation":[{"name":"Hematology Unit , Azienda Ospedaliero-Universitaria , Modena , Italy"},{"name":"Department of Medical and Surgical Sciences, Section of Hematology , University of Modena and Reggio Emilia , Modena , Italy"},{"name":"Clinical and Experimental Medicine PhD Programme, Department of Biomedical, Metabolic and Neural Sciences , University of Modena and Reggio Emilia , Modena , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Luppi","sequence":"additional","affiliation":[{"name":"Hematology Unit , Azienda Ospedaliero-Universitaria , Modena , Italy"},{"name":"Department of Medical and Surgical Sciences, Section of Hematology , University of Modena and Reggio Emilia , Modena , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Fasano","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, Department of Laboratory Medicine and Pathology , AUSL Modena , Modena , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Nasillo","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, Department of Laboratory Medicine and Pathology , AUSL Modena , Modena , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-6567","authenticated-orcid":false,"given":"Marco","family":"Marietta","sequence":"additional","affiliation":[{"name":"Hematology Unit , Azienda Ospedaliero-Universitaria , Modena , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"2026101610574580276_j_cclm-2026-1382_ref_001","unstructured":"Oxford University Press. 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