{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:57:23Z","timestamp":1771981043087,"version":"3.50.1"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Purpose: The aim of the study was to evaluate prospectively urinary \u03b1<jats:sub>1<\/jats:sub>-microglobulin as a marker of proximal tubular damage following acute pyelonephritis and outflow disease of the upper urinary tract in a urological population with minimal exclusion criteria. We also measured the urinary \u03b3-glutamyltransferase activity, urinary albumin, urinary and serum creatinine, serum IgA and serum \u03b1<jats:sub>1<\/jats:sub>-microglobulin.<\/jats:p>\n               <jats:p>Patients and methods: We studied 483 urological patients (age: 1 to 92 years, 297 men, 186 women) excluding patients receiving nephrotoxic drugs, or suffering from type 1 diabetes or renal diseases. There were 141 patients with urinary tract infection but no fever, 36 patients with high fever of non-renal origin, 51 patients with acute pyelonephritis and 156 patients with outflow disease of the upper tract, and 99 patients were incluced in the reference population.<\/jats:p>\n               <jats:p>Results: For acute pyelonephritis, vesico-ureteral reflux, and ureteral obstruction, urinary \u03b1<jats:sub>1<\/jats:sub>-microglobulin had a sensitivity of 94%, 90% and 63% respectively and a specificity of 67%, 77% and 76%. The area under the curve of the receiver operator characteristic curve was significantly (p &lt; 0.001) higher for urinary \u03b1<jats:sub>1<\/jats:sub>-microglobulin than for albumin or \u03b3-glutamyltransferase activity. Unexpected positive results were found in acute prostatitis. The urinary \u03b1<jats:sub>1<\/jats:sub>-microglobulin was the only parameter which differentiated between acute prostatitis and pyelonephritis (p &lt; 0.001). Creatinine clearance or age had little and gender had no influence on the urinary excretion of \u03b1<jats:sub>1<\/jats:sub>-microglobulin. Urine production rate significantly increases the urinary \u03b1<jats:sub>1<\/jats:sub>-microglobulin\/creatinine ratio.<\/jats:p>\n               <jats:p>Conclusion: Our results suggest that the urinary \u03b1<jats:sub>1<\/jats:sub>-microglobulin\/creatinine ratio is a diagnostically useful marker of tubular damage in acute pyelonephritis and vesico-ureteral reflux in the urological population. Following renal colic and chronic ureteral obstruction, a significant increase in urinary \u03b1<jats:sub>1<\/jats:sub>-microglobulin excretion was observed.<\/jats:p>","DOI":"10.1515\/cclm.1998.052","type":"journal-article","created":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T11:57:45Z","timestamp":1097150265000},"page":"309-315","source":"Crossref","is-referenced-by-count":24,"title":["Urinary \u03b1<sub>1<\/sub>-Microglobulin Detects Uropathy. 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