{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:54:58Z","timestamp":1768010098649,"version":"3.49.0"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Angiogenesis is a key component \nof the repair mechanisms triggered by tissue injury. Vascular endothelial growth \nfactor (VEGF) is an important mediator of angiogenesis, as it acts directly and \nspecifically on endothelial cells. VEGF produced locally in regenerating tissue \nmay spill over into the systemic circulation, and measuring levels of \ncirculating VEGF may allow monitoring of angiogenesis. To determine whether \ncirculating VEGF is increased after severe injury, we measured concentrations of \nVEGF in serial serum samples of 23 mechanical burn patients, 55 patients with \nmultiple trauma and 56 healthy normal controls, using a newly established ELISA \nassay. In burn patients, serum VEGF was increased on day 1 (369.4 \u00b1 88.0 pg\/ml) \nand on day 3 (452.0 \u00b1 65.3 pg\/ml), reached highest levels on day 14 (1809.5 \u00b1 \n239.7 pg\/ml) and was still elevated on day 21 post-burn (1339.8 \u00b1 208.7 pg\/ml) \n(mean \u00b1 SEM, p&lt;0.01), when compared with healthy controls (82.2 \u00b1 10.8 pg\/ml \n(mean \u00b1 SEM)). Likewise, in trauma patients, serum VEGF showed a trend towards \nelevated values on the day of admission (186.9 \u00b1 43.9 pg\/ml) and on day 3 after \ninjury (193.2 \u00b1 62.1 pg\/ml). Thereafter, serum VEGF increased further (day 7, \n507.0 \u00b1 114.7 pg\/ml), peaked on day 14 (742.4 \u00b1 151.8 pg\/ml) and was still \nelevated on day 21 after injury (693.1 \u00b1 218.6 pg\/ml (mean \u00b1 SEM, p&lt;0.01)). \nNo significant correlation was observed between peak serum VEGF and initial \nseverity of mechanical (Injury Severity Score) or burn injury (percentage of \nbody surface burned). However, in both burn and trauma patients, the subgroup of \npatients with uncomplicated healing showed significantly higher increases of \nserum VEGF than the subgroup who developed severe complications during the \npost-traumatic course, such as sepsis, adult respiratory distress syndrome or \nmultiple organ failure (p&lt;0.05). Thus, markedly enhanced levels of serum VEGF \nare present one to three weeks after trauma or burn injury. Further, occurrence \nof severe complications during the post-traumatic period is associated with \nlesser increases of serum VEGF.\n<\/jats:p>","DOI":"10.1515\/cclm.1998.064","type":"journal-article","created":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T11:55:18Z","timestamp":1097150118000},"page":"379-383","source":"Crossref","is-referenced-by-count":54,"title":["Strongly Enhanced Serum Levels of Vascular Endothelial Growth Factor (VEGF) after Poly-trauma and 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