{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:18:55Z","timestamp":1772612335655,"version":"3.50.1"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The effect of thyroid hormones on lipoprotein(a) plasma concentrations and the other parameters of lipoprotein metabolism was studied in 158 patients with thyroid dysfunction and in 37 euthyroid controls (cross-sectional study). Multiple regression analysis revealed that 65.5 % of the variability in lipoprotein(a) levels were predicted by changes in lipoprotein(a) phenotypes (60.5 %), thyrotropin (3.5 %), and age (0.8 %). The lipid parameters, however, showed no significant effect on lipoprotein(a). A subgroup analysis on samples from patients with large lipoprotein(a) isoforms showed that 28% of the variability in lipoprotein(a) concentrations could be explained by changes in thyroid function (19.1 %), age (6.5 %) and triglycerides (3.5 %). Much stronger correlations were found between thyrotropin and total cholesterol, low density lipoprotein cholesterol or apolipoprotein B respectively (R<jats:sup>2<\/jats:sup>=0.951 for low density lipoprotein cholesterol, R<jats:sup>2<\/jats:sup>=0.801 for apolipoprotein B). Our data suggest that thyroid hormone is a significant modulator of lipoprotein(a) metabolism. However, different mechanisms are responsible for the change in lipoprotein(a) levels and for the decrease in total-and low density lipoprotein cholesterol levels.<\/jats:p>","DOI":"10.1515\/cclm.1998.129","type":"journal-article","created":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T12:34:21Z","timestamp":1097238861000},"page":"731-735","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Thyroid Hormones on Lp(a) and Lipid Metabolism"],"prefix":"10.1515","volume":"36","author":[{"given":"Hanna","family":"Engler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter F.","family":"Riesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2005,6,1]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-3-1144"},{"key":"p_2","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1042\/bj2760825","volume":"276","author":"Salter AM","year":"1991","journal-title":"Biochem J"},{"key":"p_3","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1161\/01.CIR.74.4.758","volume":"74","author":"Dahlen GH","year":"1986","journal-title":"Circulation"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1126\/science.2530631"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109813"},{"key":"p_6","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/S0022-2275(20)42633-1","volume":"31","author":"Steyrer E","year":"1990","journal-title":"J Lipid Res"},{"key":"p_7","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1093\/clinchem\/39.12.2466","volume":"39","author":"Engler H","year":"1993","journal-title":"Clin Chem"},{"key":"p_8","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1161\/01.ATV.12.3.302","volume":"12","author":"Kraft HG","year":"1992","journal-title":"Arterioscler Thromb"},{"key":"p_9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"Friedewald WT","year":"1972","journal-title":"Clin Chem"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.2307\/1267145"},{"issue":"2","key":"p_11","first-page":"82","volume":"12","author":"Spencer CA","year":"1989","journal-title":"J Clin Immunoassay"},{"key":"p_12","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/clinchem\/41.2.226","volume":"41","author":"Kung AWC","year":"1995","journal-title":"Clin Chem"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.1.121"},{"key":"p_14","first-page":"31","volume":"20","author":"Engler H","year":"1995","journal-title":"Bull Mol Biol Med"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7827(91)90003-N"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116221"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.11.4171"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(91)90239-9"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(91)90025-X"},{"key":"p_20","doi-asserted-by":"crossref","first-page":"13284","DOI":"10.1016\/S0021-9258(18)42208-9","volume":"267","author":"Williams KJ","year":"1992","journal-title":"J Biol Chem"},{"key":"p_21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1987.tb02193.x"},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-1-51"},{"key":"p_23","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(87)90093-1"},{"key":"p_24","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979821"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004953"}],"container-title":["cclm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.1998.129\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.1998.129\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T14:54:46Z","timestamp":1647269686000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.1998.129\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9,1]]},"references-count":25,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2005,6,1]]},"published-print":{"date-parts":[[1998,9,1]]}},"alternative-id":["10.1515\/CCLM.1998.129"],"URL":"https:\/\/doi.org\/10.1515\/cclm.1998.129","relation":{},"ISSN":["1434-6621"],"issn-type":[{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[1998,9,1]]}}}