{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:24:52Z","timestamp":1789968292597,"version":"4.0.1"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endothelin-1 (ET-1), with its vasoconstrictive and proliferation-stimulating effects, could play a role in the pathogenesis of primary pulmonary hypertension. We investigated the relationship between the ET-1 like immunoreactivity and the ET-receptor density, the grade of the pulmonary vasculopathy, and properties of the pulmonary circulation in patients with pulmonary hypertension due to congenital heart disease.<\/jats:p>\n                  <jats:p>Twenty-six patients with a median age of 1 year and 1 month (6 weeks\u201317 years\u20139 months) were assigned to group I (n = 15) with a pulmonary to systemic flow ratio (Qp\/Qs) \u2265 1.5 and a pulmonary to systemic resistance ratio (Rp\/Rs) \u2264 0.3 (\u201chigh flow\u2013low resistance group\u201d) and to group II (n = 11) with a Qp\/Qs &lt; 1.5 and an Rp\/Rs &gt; 0.3 (\u201clow flow\u2013high resistance group\u201d).<\/jats:p>\n                  <jats:p>\n                    Patients belonging to group II showed a higher ET\n                    <jats:sub>A<\/jats:sub>\n                    -receptor density in lung arteries (p &lt; 0.05) and parenchyma (p &lt; 0.01) than patients in group I. Patients with the highest ET-1 like immunoreactivity in lung artery walls also showed a trend towards a higher ET\n                    <jats:sub>A<\/jats:sub>\n                    -receptor density. The ET\n                    <jats:sub>B<\/jats:sub>\n                    -receptor expression was low and not related to any of the above factors.\n                  <\/jats:p>\n                  <jats:p>Our results suggest that the paracrine lung ET-1 system is up-regulated in pediatric patients with secondary pulmonary hypertension associated with congenital heart disease.<\/jats:p>","DOI":"10.1515\/cclm.1999.069","type":"journal-article","created":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T07:19:35Z","timestamp":1097651975000},"page":"423-428","source":"Crossref","is-referenced-by-count":41,"title":["Endothelin-1- and Endothelin-Receptors in Lung Biopsies of Patients with Pulmonary Hypertension due to Congenital Heart Disease"],"prefix":"10.1515","volume":"37","author":[{"given":"Jens","family":"Lutz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Gorenflo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Habighorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Hocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2005,6,1]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711660216"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.52.5.557"},{"key":"p_3","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/01.CIR.18.4.533","volume":"18","author":"Heath D","year":"1958","journal-title":"Circulation"},{"key":"p_4","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/01.CIR.58.6.1107","volume":"58","author":"Rabinovitch M","year":"1978","journal-title":"Circulation"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1981.tb01826.x"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330607"},{"key":"p_7","first-page":"175","volume":"35","author":"Hocher B","year":"1997","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306173282402"},{"key":"p_9","doi-asserted-by":"crossref","first-page":"C1295","DOI":"10.1152\/ajpcell.1992.263.6.C1295","volume":"263","author":"Janakidevi K","year":"1992","journal-title":"Am J Physiol"},{"key":"p_10","first-page":"130","author":"Freed MD","year":"1989","journal-title":"Baltimore: Williams & Wilkins"},{"key":"p_11","first-page":"463","volume":"33","author":"Hocher B","year":"1995","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"p_12","first-page":"48","volume":"14","author":"Stewart DJ","year":"1993","journal-title":"Eur Heart J"},{"key":"p_13","first-page":"L553","volume":"266","author":"Li H","year":"1994","journal-title":"Am J Physiol"},{"key":"p_14","doi-asserted-by":"crossref","first-page":"C188","DOI":"10.1152\/ajpcell.1993.265.1.C188","volume":"265","author":"Clozel M","year":"1993","journal-title":"Am J Physiol"},{"key":"p_15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/01.RES.73.5.887","volume":"73","author":"Miyauchi T","year":"1993","journal-title":"Circulation Res"},{"key":"p_16","first-page":"H1327","volume":"266","author":"Bonvallet ST","year":"1994","journal-title":"Am J Physiol"},{"key":"p_17","doi-asserted-by":"crossref","first-page":"L690","DOI":"10.1152\/ajpcell.1995.269.3.C690","volume":"269","author":"DiCarlo VS","year":"1995","journal-title":"Am J Physiol"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119274"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00347-6"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00189-7"}],"container-title":["cclm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.1999.069\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.1999.069\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T10:32:35Z","timestamp":1647253955000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.1999.069\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4,1]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,6,1]]},"published-print":{"date-parts":[[1999,4,1]]}},"alternative-id":["10.1515\/CCLM.1999.069"],"URL":"https:\/\/doi.org\/10.1515\/cclm.1999.069","relation":{},"ISSN":["1434-6621"],"issn-type":[{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[1999,4,1]]}}}