{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:31:24Z","timestamp":1791019884496,"version":"4.1.0"},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>As glucuronidation is a major process for the metabolism\nand removal of lipophilic chemicals, polymorphic\nvariations in genes encoding the enzymes involved in\nthis process, the UDP glucuronosyltransferases (UGT),\nmay have a significant impact on our capacity to\ndetoxify and eliminate drugs and toxins. Although 24\nhuman <jats:italic>UGT<\/jats:italic> genes have been identified to date, only\npolymorphisms in five UGTs, <jats:italic>viz.<\/jats:italic> UGT1A1, UGT1A6,\nUGT2B4, UGT2B7 and UGT2B15 have been described.\nPolymorphisms in UGT1A1, the major bilirubin-glucuronidating\nform, often result in a decreased capacity\nto glucuronidate bilirubin, such as observed in Gilbert\nSyndrome and some forms of perinatal jaundice. The\nfrequencies of individual UGT1A1 polymorphisms\nshow extensive variability across ethnic groups. Two\nvariants of UGT1A6 and UGT2B4 and one variant of\nUGT2B7 and UGT2B15 have been identified. However,\nthe clinical significance of these variants is unclear.\nMore UGT polymorphisms will undoubtedly be discovered\nwhen the human genome is sequenced. However,\nunless the UGT in question is responsible for the\nexclusive metabolism of a particular drug or chemical\n(<jats:italic>e.g.<\/jats:italic> UGT1A1 and bilirubin) or is the predominant or\nonly UGT present in the cell, it is unlikely that these\npolymorphisms will be of major clinical significance.<\/jats:p>","DOI":"10.1515\/cclm.2000.129","type":"journal-article","created":{"date-parts":[[2004,10,22]],"date-time":"2004-10-22T10:39:26Z","timestamp":1098441566000},"page":"889-892","source":"Crossref","is-referenced-by-count":87,"title":["Polymorphisms in UDP Glucuronosyltransferase Genes: Functional Consequences and Clinical Relevance"],"prefix":"10.1515","volume":"38","author":[{"given":"Peter I.","family":"Mackenzie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John O.","family":"Miners","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross 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