{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T05:25:38Z","timestamp":1751865938806},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Expression profiling using methods of functional genomics\ncan be used to investigate changes in gene\ntranscription induced by drug treatment, which may\nlead to discovery of new potential drug targets. Antipsychotic\nagents alleviate symptoms of schizophrenia\nbut the mechanism behind their clinical efficacy is\nunclear. We have used the PC12 cell line as a model to\ncharacterize effects of the antipsychotic drug chlorpromazine\non gene expression using high-density complementary\nDNA array filters prepared from a rat brain\nentorhinal cortex complementary DNA library. Chlorpromazine\ntreatment positively regulated the expression\nof several clones, five of which were selected for\nfurther characterization. Northern blotting experiments\nconfirmed the increased expression of these\ngenes after chlorpromazine treatment. Sequencing revealed\nthat two clones were cytochrome c oxidase and\nthree were novel genes. Characterization of the function\nof these genes could increase our understanding\nof the mechanisms of action of antipsychotic drugs,\nand might be beneficial for the development of more\neffective agents.<\/jats:p>","DOI":"10.1515\/cclm.2000.133","type":"journal-article","created":{"date-parts":[[2004,10,22]],"date-time":"2004-10-22T10:39:26Z","timestamp":1098441566000},"page":"911-915","source":"Crossref","is-referenced-by-count":3,"title":["A Functional Genomic Study of the Effects of Antipsychotic Agent Chlorpromazine in PC12 Cells"],"prefix":"10.1515","volume":"38","author":[{"given":"Outi","family":"Kontkanen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merja","family":"Lakso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garry","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eero","family":"Castr\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2005,6,1]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5235.467"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1297-1359"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(95)00023-Y"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5287.610"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5454.873"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.9212"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2150"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1038\/4475"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-1669(98)80144-4"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.12.5350"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1354393"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5235.484"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.040537997"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.11.4376"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1126\/science.3854"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.7.2424"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245602"},{"key":"p_20","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1111\/j.1476-5381.1995.tb17214.x","volume":"116","author":"Nakazawa K","year":"1995","journal-title":"Br J Pharmacol"},{"key":"p_21","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90165-3"},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1038\/4455"},{"key":"p_23","doi-asserted-by":"publisher","DOI":"10.1038\/4434"},{"key":"p_24","doi-asserted-by":"publisher","DOI":"10.1126\/science.1990438"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00524-4"}],"container-title":["cclm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2000.133\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2000.133\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T14:43:41Z","timestamp":1647269021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2000.133\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,18]]},"references-count":24,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2005,6,1]]},"published-print":{"date-parts":[[2000,9,18]]}},"alternative-id":["10.1515\/CCLM.2000.133"],"URL":"https:\/\/doi.org\/10.1515\/cclm.2000.133","relation":{},"ISSN":["1434-6621"],"issn-type":[{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9,18]]}}}