{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:11:24Z","timestamp":1759482684389},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,1,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was designed to test the hypothesis that impaired neutrophil function might contribute to the development of bacterial pneumonia in patients with HIV-infection. Numbers of inflammatory cells and immunoglobulin G Fc\u03b3 receptor (IgG Fc\u03b3R) I, II, III levels were investigated in bronchoalveolar lavage (BAL) fluid of HIV-seronegative and HIV-infected patients with bacterial pneumonia. The 99 patients were classified into three groups: I: HIV-seronegative and pneumonia (n=40); II: HIV-infected and pneumonia (n=19); III: HIV-seronegative with other pulmonary diseases than pneumonia (n=40). The results of groups I and II, II and III, and I and III were compared. The percentage of alveolar macrophages was significantly lower (group II vs. III: p=0.005, group I vs. III: p=0.001), that of neutrophils increased significantly in patients with pneumonia (group II vs. III: p=0.02, group I vs. III: p=0.01). Lymphocytes differed only between groups I and III (p=0.04). Although only the expression of Fc\u03b3RI was significantly higher in HIV-seronegative pneumonia patients compared to those without pneumonia (p=0.01), the mean expression of all three receptors was lower in the HIV-infected group, with that of Fc\u03b3RI approaching statistical significance.<\/jats:p><jats:p>This report provides first evidence that altered Fc\u03b3R expression on BAL neutrophils might contribute to the increased susceptibility of HIV-infected patients to bacterial pneumonia.<\/jats:p>","DOI":"10.1515\/cclm.2004.035","type":"journal-article","created":{"date-parts":[[2004,8,25]],"date-time":"2004-08-25T14:34:45Z","timestamp":1093444485000},"source":"Crossref","is-referenced-by-count":3,"title":["Immunoglobulin G Fc\u03b3 receptor expression on polymorphonuclear cells in bronchoalveolar lavage fluid of HIV-infected and HIV-seronegative patients with bacterial 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