{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:37:36Z","timestamp":1791934656850,"version":"4.3.4"},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum N-acetyl-\u03b2-D-glucosaminidase (NAG; EC 3.2.1.30) is a hexosaminidase and may be a predictor of vascular injury, e.g., in infant respiratory distress syndrome, pneumonia, broncho-pulmonary dysplasia and necrotizing enterocolitis. To estimate the new diagnostic prospects we have modified our urinary NAG assay. In this sensitive colorimetric micro-assay, VRA-GlcNAc was used as a substrate. In the present study the age dependence of serum NAG activity was investigated in newborn babies, infants (1\u201324 months), children (2\u201318 years) and adults (19\u201380 years). Serum NAG activity was found to be age-dependent; it is higher in early childhood (11\u201359 U\/l) but decreases to a constant value at the age of 1\u20132 years. After the age of 2 years it is similar to adults' NAG (10\u201330 U\/l). In pediatrics age-matched reference ranges must be taken into consideration.<\/jats:p>","DOI":"10.1515\/cclm.2004.055","type":"journal-article","created":{"date-parts":[[2004,8,25]],"date-time":"2004-08-25T14:37:54Z","timestamp":1093444674000},"source":"Crossref","is-referenced-by-count":6,"title":["Age dependence of serum \u03b2-N-acetylhexosaminidase (NAG) activity"],"prefix":"10.1515","volume":"42","author":[{"given":"Anna V.","family":"Ol\u00e1h","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Cs\u00e1thy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Orsz\u00e1gh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Ol\u00e1h","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199612000-00014"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(73)90481-6"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(98)00129-6"},{"key":"p_4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000242522","volume":"49","author":"Shattuck KE","year":"1986","journal-title":"Biol Neonate"},{"key":"p_5","first-page":"595","volume":"30","author":"Goi G","year":"1992","journal-title":"Eur J Clin Chem Biochem"},{"key":"p_6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000468700","volume":"43","author":"Jung K","year":"1990","journal-title":"Enzyme"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(82)90092-0"},{"key":"p_8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/000456329403100115","volume":"31","author":"Ol\u00e1h VA","year":"1994","journal-title":"Ann Clin Biochem"},{"key":"p_9","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/clinchem\/27.7.1180","volume":"27","author":"Horak E","year":"1981","journal-title":"Clin Chem"},{"key":"p_10","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/000456329202900307","volume":"29","author":"P\u00f3csi I","year":"1992","journal-title":"Ann Clin Biochem"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1136\/adc.55.9.719"},{"key":"p_12","first-page":"545","volume":"45","author":"Mandic L","year":"1998","journal-title":"Biochem Mol Biol Int"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1007\/BF02624671"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90033-3"},{"key":"p_15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1056\/NEJM197007022830104","volume":"283","author":"O'Brien JS","year":"1970","journal-title":"N Engl J Med"},{"key":"p_16","first-page":"693","volume":"30","author":"Price RG","year":"1992","journal-title":"Eur J Clin Chem Biochem"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(85)90274-8"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00025-X"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/cclm.2004.42.issue-3\/cclm.2004.055\/cclm.2004.055.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2004.055\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T22:42:28Z","timestamp":1619044948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2004.055\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,9]]},"references-count":18,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1515\/cclm.2004.055","relation":{},"ISSN":["1437-4331","1434-6621"],"issn-type":[{"value":"1437-4331","type":"electronic"},{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1,9]]}}}