{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:16:56Z","timestamp":1783487816549,"version":"3.55.0"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Assays for insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) have become essential tools in the diagnostic work-up of disorders of the somatotropic axis in children and adults. The aim of this study was to evaluate the automated IMMULITE<\/jats:p>","DOI":"10.1515\/cclm.2004.112","type":"journal-article","created":{"date-parts":[[2004,8,25]],"date-time":"2004-08-25T15:24:28Z","timestamp":1093447468000},"source":"Crossref","is-referenced-by-count":211,"title":["Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3)"],"prefix":"10.1515","volume":"42","author":[{"given":"Martin W.","family":"Elmlinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"K\u00fchnel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias M.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Ranke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref321","first-page":"50","article-title":"GH replacement in growth hormone deficient hypopituitary adults : demo - graphic and clinical characteristics , dosing and safety","author":"Abs","year":"1999","journal-title":"Clin Endocrinol"},{"key":"ref281","first-page":"37","article-title":"The IMMULITE assay tube : a new approach to heterogeneous ligand assay","volume":"2","author":"Babson","year":"1991","journal-title":"Clin Chem"},{"key":"ref201","first-page":"90","article-title":"Serum soma - tomedin - C in hypopituitarism and in other disorders of growth","author":"Ercole","year":"1977","journal-title":"J Pediatr"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1210\/jcem.83.11.5223","article-title":"Optimizing growth hormone replacement therapy by dose titration in hypopituitary adults","volume":"83","author":"Drake","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref141","first-page":"1365","article-title":"Ranke MB New paradigms for growth hormone treat - ment in the st century : prediction models","volume":"21","author":"Suppl","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref161","first-page":"279","article-title":"Plasma insulin - like growth factor - I and prostate cancer risk : a prospec - tive study","author":"Chan","year":"1998","journal-title":"Science"},{"key":"ref71","first-page":"692","article-title":"Insulin - like growth factors","author":"LeRoith","year":"1993","journal-title":"Ann NY Acad Sci"},{"key":"ref31","first-page":"253","article-title":"RE The amino acid sequence of human insulin - like growth factor I and its structural homology with proinsulin","author":"Rinderknecht","year":"1978","journal-title":"J Biol Chem"},{"key":"ref231","first-page":"68","article-title":"Radioimmunological deter - mination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extra - pancreatic tumor hypoglycemia","author":"Zapf","year":"1981","journal-title":"J Clin Invest"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0300-595X(84)80011-0","article-title":"Factors controlling blood concentration of somatomedin C","volume":"13","author":"Clemmons","year":"1984","journal-title":"Clin Endocrinol Metab"},{"key":"ref241","first-page":"73","article-title":"Commercial assays available for insulin - like growth factor I and their use in diagnosing growth hormone deficiency","volume":"55","author":"Clemmons","year":"2001","journal-title":"Horm Res"},{"key":"ref91","first-page":"1532","article-title":"Diagnostic controversy : the diagnosis of childhood growth hormone deficiency revisited","volume":"80","author":"Rosenfeld","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"ref131","first-page":"343","article-title":"Diagno - sis of growth - hormone deficiency in adults","author":"Hoffman","year":"1994","journal-title":"Lancet"},{"key":"ref151","first-page":"144","article-title":"- mer A new and accurate prediction model for growth response to growth hormone treat - ment in children with growth hormone deficiency","author":"Schonau","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"ref301","first-page":"80","article-title":"Serum levels of insulin - like growth factor - binding protein - ) in healthy infants children and adolescents : the relation to IGF - IGF - II IGFBP age sex body mass index , and pubertal maturation","author":"Juul","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1054\/ghir.2000.0171","article-title":"Does the GH - IGF axis play a role in cancer pathogenesis","volume":"10","author":"Cohen","year":"2000","journal-title":"Growth Horm IGF Res"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1515\/jpem-2000-s610","article-title":"Role of insulin - like growth factor monitoring in optimizing growth hormone therapy","volume":"13","author":"Wetterau","year":"2000","journal-title":"Pediatr Endocrinol Metab"},{"key":"ref271","first-page":"11","article-title":"Radioimmunoassays for IGFs and IGFBPs","volume":"4","author":"Blum","year":"1994","journal-title":"Growth Regul"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000191304","article-title":"Functional role of insulin - like growth factor binding proteins","volume":"48","author":"Ranke","year":"1997","journal-title":"Horm Res"},{"key":"ref171","first-page":"351","article-title":"Circulating concentrations of insulin - like growth factor - I and risk of breast cancer","author":"Hankinson","year":"1998","journal-title":"Lancet"},{"key":"ref261","first-page":"259","article-title":"Evaluation of total IGF - I assay methods using samples from type I and type II diabetic patients","author":"Chestnut","year":"2002","journal-title":"J Immunol Methods"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/clinchem\/28.3.488","article-title":"Radioimmunoassay for somatomedin : comparison with radioreceptor assay in patients with growth - hormone disorders , hypothyroid - ism , and renal failure","volume":"28","author":"Baxter","year":"1982","journal-title":"Clin Chem"},{"key":"ref111","first-page":"664","article-title":"Insulin - like growth factor bind - : IGF and IGFBP automated non - isotopic assays ing protein - generation as a measure of GH sensitivity","author":"Buckway","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref211","first-page":"301","article-title":"- berg Evaluation of acromegaly by radioimmunoassay of somatomedin -","author":"Clemmons","year":"1979","journal-title":"Engl J Med"},{"key":"ref51","first-page":"76","article-title":"Ranke MB Serum levels of insulin - like growth factor I and IGF binding protein reflect spontaneous growth hor - mone secretion","volume":"6","author":"Blum","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","first-page":"123","article-title":"Christian - sen JS Circadian patterns of serum insulin - like growth factor II and IGF binding protein in growth hor - mone - deficient patients and age - and sex - matched nor - mal subjects","author":"Jorgensen","year":"1990","journal-title":"Acta Endocrinol"},{"key":"ref11","first-page":"2889","article-title":"Growth response to growth hormone treatment relates to serum insulin - like growth factor I and IGF - binding protein - in short children with various GH secretion capacities Swedish Study Group for Growth Hormone Treatment","volume":"82","author":"Kristrom","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref291","first-page":"125","article-title":"Das RE The International Ref - erence Reagent for insulin - like growth factor - I","author":"Bristow","year":"1990","journal-title":"crinol"},{"key":"ref101","first-page":"3","article-title":"Significance of basal IGF - and IGFBP measurements in the diagnostics of short stature in children","volume":"54","author":"Ranke","year":"2000","journal-title":"Horm Res"},{"key":"ref251","first-page":"106","article-title":"How should insulin - like growth factor I be measured ? A consensus statement","volume":"55","author":"Ranke","year":"2001","journal-title":"Horm Res"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1210\/edrv.19.2.0329","article-title":"The diag - nosis of growth hormone deficiency in children and adults","volume":"19","author":"Shalet","year":"1998","journal-title":"Endocr Rev"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/cclm.2004.42.issue-6\/cclm.2004.112\/cclm.2004.112.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2004.112\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T07:01:56Z","timestamp":1705215716000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2004.112\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,7]]},"references-count":31,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1515\/cclm.2004.112","relation":{},"ISSN":["1437-4331","1434-6621"],"issn-type":[{"value":"1437-4331","type":"electronic"},{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1,7]]}}}