{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:53:45Z","timestamp":1761742425749},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radiofrequency (RF) catheter ablation has been shown to be highly effective in the treatment of supraventricular tachycardias. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (B-type natriuretic peptide; BNP) are secreted by the heart mainly in response to myocardial stretch induced by volume load. The aim of the present study was to determine the time course of the N-terminal prohormone forms of ANP (NT-proANP) and BNP (NT-proBNP) in patients undergoing radiofrequency (RF) catheter ablation for paroxysmal supraventricular tachycardias.<\/jats:p><jats:p>Serial blood samples were taken from 13 patients with symptomatic paroxysmal supraventricular tachycardias undergoing RF ablation and from 13 age- and gender-matched healthy controls. Blood was taken before ablation (day 0, baseline), and at day one and day 120 after ablation. Levels of NT-proANP were significantly higher before RF ablation (4862 \u00b1 726 pmol\/l) as compared to day one (2021 \u00b1 220 pmol\/l) and day 120 after RF ablation (2470 \u00b1 349 pmol\/l) (with p &lt; 0.01 on day one and p &lt; 0.05 on day 120; n = 13). The size of the left atrium decreased from 41.0 \u00b1 5.5 mm before ablation to 34.9 \u00b1 5.9 mm (n = 13; p &lt; 0.05) on day 120 as measured by M-mode echocardiography. Levels of NT-proBNP showed comparable values before and on day one and day 120 after ablation and were not significantly elevated as compared to healthy controls.<\/jats:p><jats:p>NT-proANP levels are increased in patients presenting with paroxysmal supraventricular tachycardias and decrease one day after radiofrequency catheter ablation, possibly reflecting a transient reduction of ANP secretion from injured myocardial cells. Lower NT-proANP levels in the long-term time course may result from reduction of atrial volume load and reconstitution of atrial architecture after successful treatment of supraventricular tachycardias. NT-proANP may serve as a useful laboratory marker to describe the long-term interventional success after RF ablation.<\/jats:p>","DOI":"10.1515\/cclm.2004.145","type":"journal-article","created":{"date-parts":[[2004,8,16]],"date-time":"2004-08-16T14:41:36Z","timestamp":1092667296000},"source":"Crossref","is-referenced-by-count":4,"title":["N-terminal pro-atrial natriuretic peptide as a biochemical marker of long-term interventional success after radiofrequency catheter ablation of paroxysmal supraventricular tachyarrhythmias"],"prefix":"10.1515","volume":"42","author":[{"given":"Martina","family":"Brueckmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bertsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens J.","family":"Kaden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Wolpert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guenter","family":"Huhle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Borggrefe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl K.","family":"Haase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref131","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/oxfordjournals.eurheartj.a062554","article-title":"Atrial natriuretic peptide in atrial fibrillation after electrical cardioversion therapy","volume":"9","author":"Petersen","year":"1988","journal-title":"Eur Heart J"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0002-9149(91)90045-M","article-title":"Atrial natriuretic peptide response to cardioversion of atrial flutter and fibrillation and role of associated heart failure","volume":"67","author":"Mookherjee","year":"1991","journal-title":"Am J Cardiol"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.amjcard.2003.07.010","article-title":"Brain natriuretic peptide is elevated in outpatients with atrial fibrillation","volume":"92","author":"Silvet","year":"2003","journal-title":"Am J Cardiol"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0735-1097(00)00515-5","article-title":"Natriuretic peptides in atrial fibrillation : a prospective hormonal and Doppler - 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