{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T21:57:28Z","timestamp":1715723848856},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The soluble transferrin receptor (sTfR) distinguishes iron deficiency anemia from other types of anemia. Refractory iron deficiency anemia is often the onset symptom in malabsorption-induced celiac disease. We evaluated whether sTfR levels distinguish celiac disease-associated iron deficiency anemia from iron deficiency anemia of other origin. To this aim we measured sTfR and ferritin levels and their ratio (the sTfR\/ferritin index) and other hematological parameters in 42 anemic children (20 with and 22 without celiac disease) vs. 22 non-anemic children with celiac disease and 31 healthy controls (age range 4\u201312years). Hemoglobin parameters, mean cell volume, and serum iron and ferritin levels were decreased to a similar extent in the anemic patients (celiac and non-celiac). The sTfR level in non-anemic celiac patients was similar to that of normal controls (1.7\u00b10.35mg\/L), whereas it was significantly increased in non-celiac and celiac anemic patients (2.2\u00b10.5mg\/L, p&lt;0.05 and 2.7\u00b11.2mg\/L, p&lt;0.001, respectively). The sTfR\/ferritin index was also increased more in the anemic celiac patients (mean 4.4, range 1.5\u201312.0) than in anemic non-celiac children (mean 2.6, range 1.4\u20134.0) compared with non-anemic children (mean 1.2, range 0.7\u20132.0). Differences were more pronounced when ferritin was &lt;5ng\/mL. Thus, the sTfR\/ferritin index may be a predictive measure in discriminating anemic patients with celiac disease from those without celiac disease.<\/jats:p>","DOI":"10.1515\/cclm.2005.005","type":"journal-article","created":{"date-parts":[[2005,1,6]],"date-time":"2005-01-06T17:19:31Z","timestamp":1105031971000},"source":"Crossref","is-referenced-by-count":5,"title":["The soluble transferrin receptor (sTfR)-ferritin index is a potential predictor of celiac disease in children with refractory iron deficiency anemia"],"prefix":"10.1515","volume":"43","author":[{"given":"Maurizio","family":"De Caterina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Di Pascale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana","family":"Salerno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assunta","family":"Rosiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Passaretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Scopacasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref251","article-title":"Divalent metal transporter and transferrin receptor expression in duodenal biopsies from celiac patients","volume":"20","author":"Barisani","year":"2001","journal-title":"abstract Dig Dis Week"},{"key":"ref41","first-page":"75","article-title":"Serum transferrin receptor as an index of iron absorption","volume":"9","author":"Cook","year":"1990","journal-title":"Br Haematol"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/clinchem\/44.1.45","article-title":"The clinical utility of the serum transferrin receptor in the evaluation of iron deficiency anemia","volume":"44","author":"Mast","year":"1998","journal-title":"Clin Chem"},{"key":"ref61","first-page":"119","article-title":"Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia","author":"Ferguson","year":"1992","journal-title":"J Lab Clin Med"},{"key":"ref241","first-page":"80","article-title":"Iron deficiency in celiac disease is mild and it is detected and corrected by gluten - 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