{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:46:11Z","timestamp":1780649171558,"version":"3.54.1"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the clinical usefulness of antepartum clinical characteristics, along with measures of glucose tolerance, in Dutch multiethnic women with gestational diabetes mellitus (GDM) for their ability to predict type 2 diabetes within 6months of delivery (early postpartum diabetes). The present study comprised a cross-sectional 5-year investigation (1998\u20132003) of a consecutive series of 168 women with GDM identified by a two-stage protocol at 16\u201333weeks of gestation. The following data were collected for all women: age and gestational age at entry into the study; prepregnancy body mass index (BMI); ethnicity; obstetric and clinical history, including the onset of early postpartum diabetes; pregnancy outcome; level of fasting C-peptide; and glycemic parameters of 50-g 1-h glucose challenge test and 100-g 3-h oral glucose tolerance test (diagnostic OGTT). We used receiver operating characteristic (ROC) curve analysis to test the clinical usefulness of the glycemic parameters. A total of 11 women (6.5%) developed early postpartum diabetes. Apart from family history of diabetes (p=0.052), anthropometric, maternal, and neonatal clinical parameters showed no association with early postpartum diabetes in univariate analyses. The level of fasting glucose, and both the glucose challenge test and diagnostic OGTT post-load glucose levels and glucose areas were associated with early postpartum diabetes. ROC curve analysis identifiedall three glucose challenge-test parameters, including fasting glucose concentration, as poor diagnostic tests, with a positive predictive value of \u223c22%, whereas the positive predictive value associated with the area under the diagnostic OGTT curve increased progressively over monitoring time from 20.6% to 100%. Using a 3-h OGTT glucose area threshold of 35.7mmol\u00b7h\/L resulted in 100% sensitivity and 100% specificity, identifying the 11 women who developed early postpartum diabetes. In summary, we can conclude from the present analysis that early postpartum diabetes is rare in GDM women (6.5%), and that the clinical usefulness of the total area under the diagnostic 3-h OGTT is superior to all other glycemic parameters for detecting early postpartum diabetes.<\/jats:p>","DOI":"10.1515\/cclm.2006.019","type":"journal-article","created":{"date-parts":[[2005,12,24]],"date-time":"2005-12-24T14:54:40Z","timestamp":1135436080000},"source":"Crossref","is-referenced-by-count":8,"title":["The clinical usefulness of glucose tolerance testing in gestational diabetes to predict early postpartum diabetes mellitus"],"prefix":"10.1515","volume":"44","author":[{"given":"Rob N.M.","family":"Weijers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dik J.","family":"Bekedam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk M.J.","family":"Goldschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvo M.","family":"Smulders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref81","first-page":"17","article-title":"Standardization of biochemical methods in the diagnosis and management of diabetes","volume":"27","author":"Alberti","year":"1982","journal-title":"IDF Bulletin"},{"key":"ref71","first-page":"161","article-title":"Summary and recommendations of the Fourth International Workshop - Conference on Gestational Diabetes Mellitus","volume":"21","author":"Metzger","year":"1998","journal-title":"Diabetes Care"},{"key":"ref91","article-title":"Definition diagnosis , and classification of diabetes mellitus and its complications Report of a WHO consultation","author":"Geneva","year":"1999","journal-title":"World Health Organization World Health Organization"},{"key":"ref21","first-page":"163","article-title":"Gestational diabetes mellitus : the prevalence of glucose intolerance and diabetes mellitusin the first two months post partum","author":"Kjos","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"ref121","first-page":"103","article-title":"Polycystic ovary syndrome","author":"Guzick","year":"2004","journal-title":"Obstet Gynecol"},{"key":"ref171","first-page":"103","article-title":"Glucose screening in Mexican - American women","author":"Yogev","year":"2004","journal-title":"Obstet Gynecol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.2337\/diacare.16.12.1598","article-title":"Prepregnancy weight and antepartum insulin secretion predict glucose tolerance five years after gestational diabetes mellitus","volume":"16","author":"Metzger","year":"1993","journal-title":"Diabetes Care"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2337\/diacare.18.7.1029","article-title":"The epidemiology of diabetes and pregnancy in the US","volume":"18","author":"Engelgau","year":"1988","journal-title":"Diabetes Care"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1046\/j.1464-5491.2002.00684.x","article-title":"Screening for gestational diabetes ; past , present and future","volume":"19","author":"Hanna","year":"2002","journal-title":"Diabet Med"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"586","DOI":"10.2337\/diab.44.5.586","article-title":"Predicting future diabetes in Latino women with gestational diabetes : utility of early postpartum glucose tolerance testing","volume":"44","author":"Kjos","year":"1995","journal-title":"Diabetes"},{"key":"ref191","first-page":"86","article-title":"Gestational diabetes : antenatal variables as predictors of postpartum glucose intolerance","author":"Greenberg","year":"1995","journal-title":"Obstet Gynecol"},{"key":"ref11","first-page":"186","article-title":"Clinical predictors for a high risk for the development of diabetes mellitus in the early puerperium in women with recent gestational diabetes mellitus","author":"Schaefer","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2337\/diacare.25.1.72","article-title":"Determinants of mild gestational hyperglycemia and gestational diabetes mellitus in a large Dutch multiethnic cohort","volume":"25","author":"Weijers","year":"2002","journal-title":"Diabetes Care"},{"key":"ref141","first-page":"777","article-title":"der Multicentre evaluation of the EBIO plus glucose analyser","volume":"34","author":"Treskes","year":"1996","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"ref61","first-page":"165","article-title":"Screening recommendations for gestational diabetes mellitus","author":"Cousins","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/00365519709168308","article-title":"Mathematical tools for demonstrating the clinical usefulness of biochemical markers","volume":"57","author":"Boyd","year":"1997","journal-title":"Scand J Lab Invest"},{"key":"ref51","first-page":"167","article-title":"Predictive factors for the development of diabetes in women with previous gestational diabetes mellitus","author":"Damm","year":"1992","journal-title":"Am J Obstet Gynecol"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/cclm.2006.44.issue-1\/cclm.2006.019\/cclm.2006.019.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2006.019\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T22:46:42Z","timestamp":1619045202000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2006.019\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,1]]},"references-count":17,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1515\/cclm.2006.019","relation":{},"ISSN":["1434-6621","1437-4331"],"issn-type":[{"value":"1434-6621","type":"print"},{"value":"1437-4331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,1]]}}}