{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:19:18Z","timestamp":1791094758055,"version":"4.1.0"},"reference-count":14,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bullous skin diseases represent a group of organ-specific autoimmune disorders characterised by binding of circulating autoantibodies to adhesion molecules of the epidermis and the dermo-epidermal basement membrane zone. Binding of these autoantibodies to their antigenic targets results in loss of adhesion between epidermal keratinocytes and at the level of the basement membrane zone. Chronic blisters and secondary painful erosions are the clinical hallmark of autoimmune bullous disorders. Histopathology reveals the location of blister formation and helps to classify the subtype of the bullous skin disorder. Immunofluorescence is crucial for diagnosing autoimmune bullous skin disorders. Tissue-bound autoantibodies are detected by direct immunofluorescence of perilesional skin. Circulating autoantibodies can be visualised by indirect immunofluorescence using tissue substrates such as monkey oesophagus and sodium chloride-split human skin. Most of the autoantigens are available as recombinant proteins, which allows for autoantibody screening by ELISA or immunoblot analysis to confirm the primary diagnosis and, importantly, for immunoserological follow-up of patients.<\/jats:p>","DOI":"10.1515\/cclm.2006.027","type":"journal-article","created":{"date-parts":[[2006,2,14]],"date-time":"2006-02-14T00:15:57Z","timestamp":1139876157000},"source":"Crossref","is-referenced-by-count":17,"title":["Autoimmune bullous disorders"],"prefix":"10.1515","volume":"44","author":[{"given":"R\u00fcdiger","family":"Eming","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hertl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1749-6632.1983.tb22220.x","article-title":"IgA class endomysium antibodies in dermatitis herpetiformis and coeliac disease","volume":"4","author":"Chorzelski","year":"1983","journal-title":"Ann NY Acad Sci"},{"key":"ref11","first-page":"122","article-title":"Humoral and cellular autoimmunity in autoimmune bullous skin disorders","author":"Hertl","year":"2000","journal-title":"Int Arch Allergy Immumol"},{"key":"ref71","first-page":"230","article-title":"BP and BP auto - 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encoded form of bullous pemphigoid antigen","author":"Haase","year":"1998","journal-title":"J Invest Dermatol"},{"key":"ref21","first-page":"53","article-title":"Bullous autoimmune dermatoses Diagnosis and therapy","author":"Hertl","year":"2002","journal-title":"Hautarzt"},{"key":"ref121","first-page":"1","article-title":"Usefulness of enzyme - linked immunosorbent assay using recombinant desmogleins and for serodiagnosis of pemphigus","author":"Amagai","year":"1999","journal-title":"Br J Dermatol"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1600-0625.2005.00367.x","article-title":"Mechanisms of blister induction by autoantibodies","volume":"14","author":"Sitaru","year":"2005","journal-title":"Exp Dermatol"},{"key":"ref81","first-page":"108","article-title":"Development of an ELISA for rapid detection of anti - type VII collagen autoantibodies in epidermolysis bullosa acquisita","author":"Chen","year":"1997","journal-title":"J Invest Dermatol"},{"key":"ref111","first-page":"5","article-title":"Detection of laminin - specific auto - antibodies in mucous membrane and bullous pemphigoid sera by ELISA","author":"Bekou","year":"2005","journal-title":"J Invest Dermatol"},{"key":"ref61","first-page":"144","article-title":"Detection of autoantibodies of various subclasses against desmoglein in patients with acute onset and chronic pemphigus vulgaris","author":"Sp\u00e4th","year":"2001","journal-title":"Br J Dermatol"},{"key":"ref41","first-page":"109","article-title":"Tight clustering of extracellular BP epitopes recognized by bullous pemphigoid autoantibodies","volume":"180","author":"Zillikens","year":"1997","journal-title":"J Invest Dermatol"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/cclm.2006.44.issue-2\/cclm.2006.027\/cclm.2006.027.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2006.027\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T22:46:46Z","timestamp":1619045206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2006.027\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,1]]},"references-count":14,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1515\/cclm.2006.027","relation":{},"ISSN":["1434-6621","1437-4331"],"issn-type":[{"value":"1434-6621","type":"print"},{"value":"1437-4331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,1]]}}}