{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:10:12Z","timestamp":1772806212153,"version":"3.50.1"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We measured the concentrations of cardiac troponin T (cTnT) and amino-terminal pro-natriuretic peptide (NT-proBNP) in umbilical cord blood during the second trimester (20\u201325weeks of gestation) and at delivery in 109 uncomplicated pregnancies to define reference values. Using the 97.5th percentile, the upper reference limits for cTnT and NT-proBNP were 0.308ng\/mL and 5402pg\/mL in fetuses in the second trimester, and 0.038ng\/mL and 1690pg\/mL in healthy neonates, respectively. We also evaluated whether labor and delivery mode affected the concentrations of the two analytes. We found significantly higher (p&lt;0.001) umbilical blood NT-proBNP and cTnT levels at 20\u201325weeks of gestation than at term. In addition, within the term group, NT-proBNP concentrations were significantly higher in women delivering by elective cesarean section than in women delivering spontaneously (p&lt;0.001), and higher than in women delivering by cesarean section during active labor. This indicates that the decrease in NT-proBNP levels is probably due to labor rather than delivery mode. Finally, we confirmed the at-birth reference values previously established for cTnT and NT-proBNP.<\/jats:p><jats:p>Clin Chem Lab Med 2006;44:834\u20136.<\/jats:p>","DOI":"10.1515\/cclm.2006.144","type":"journal-article","created":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T10:12:32Z","timestamp":1150452752000},"source":"Crossref","is-referenced-by-count":24,"title":["Cardiac troponin T and amino-terminal pro-natriuretic peptide concentrations in fetuses in the second trimester and in healthy neonates"],"prefix":"10.1515","volume":"44","author":[{"given":"Giuliana","family":"Fortunato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Carandente Giarrusso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Sglavo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Vassallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Tomeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelangelo","family":"Rea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Paladini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref81","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1111\/j.1651-2227.2003.tb00832.x","article-title":"Cardiac troponin cardiac troponin T and creatine kinase MB concentrations in umbilical cord blood of healthy term neonates","author":"Trevisanuto","year":"2003","journal-title":"Acta Paediatr"},{"key":"ref131","first-page":"201","article-title":"Fetal cardiovascular physiology","author":"Rychik","year":"2004","journal-title":"Pediatr Cardiol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.clinbiochem.2004.08.003","article-title":"Reference values for cardiac troponins T and I in healthy neonates","author":"Baum","year":"2004","journal-title":"Clin Biochem"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1161\/01.RES.76.4.681","article-title":"Molecular basis of human cardiac troponin T isoforms expressed in the developing , adult , and failing heart","author":"Anderson","year":"1995","journal-title":"Circ Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s002460010257","article-title":"Cardiac troponin I and - 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terminal pro - - type natriuretic peptide in umbilical cord blood","volume":"50","author":"Bakker","year":"2004","journal-title":"Clin Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1373\/clinchem.2004.046557","article-title":"Terminal pro - - type natriuretic peptide concentrations are markedly higher in the umbilical cord blood of newborns than in their mothers","volume":"5","author":"Hammerer","year":"2005","journal-title":"Clin Chem"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1067\/mob.2002.118845","article-title":"Natriuretic peptides in the pathogenesis of cardiac dysfunction in the recipient fetus of twin - twin transfusion syndrome","author":"Bajoria","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.0001-6349.2005.00700.x","article-title":"Fetal hemodynamic changes after amniotomy","author":"Fok","year":"2005","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/00004872-200205000-00001","article-title":"Natriuretic peptide system in fetal heart and circulation","author":"Walther","year":"2002","journal-title":"J Hypertens"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/01.CIR.94.3.472","article-title":"Cardiac troponin T isoform expression correlates with pathophysiological descriptors in patients who underwent corrective surgery for congenital heart disease","volume":"6","author":"Saba","year":"1996","journal-title":"Circulation"},{"key":"ref01","first-page":"537","article-title":"de Combining natriuretic peptides and necrosis markers in the assessment of acute coronary syndromes","author":"Lemos","year":"2003","journal-title":"Rev Cardiovasc Med"},{"key":"ref91","first-page":"237","article-title":"Cardiac troponin T gene expression in muscle","author":"Mar","year":"1992","journal-title":"Symp Soc Exp Biol"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1161\/01.RES.0000126698.37440.B0","article-title":"de Tombe Titin and the developing heart","volume":"2","author":"Walker","year":"2004","journal-title":"Circ Res"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/cclm.2006.44.issue-7\/cclm.2006.144\/cclm.2006.144.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2006.144\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T21:31:22Z","timestamp":1707082282000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2006.144\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,1]]},"references-count":17,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.1515\/cclm.2006.144","relation":{},"ISSN":["1434-6621","1437-4331"],"issn-type":[{"value":"1434-6621","type":"print"},{"value":"1437-4331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,1]]}}}