{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:21:34Z","timestamp":1780449694948,"version":"3.54.1"},"reference-count":98,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the past two decades, flow-cytometric immunophenotyping of lymphocytes has evolved from a research technique into a routine laboratory diagnostic test. Extensive studies in healthy individuals resulted in detailed age-related reference values for different lymphocyte subpopulations in peripheral blood. This is an important tool for the diagnosis of hematological and immunological disorders. Similar, albeit less detailed, information is now available for other lymphoid organs, e.g., normal bone marrow, lymph nodes, tonsils, thymus and spleen. Flow-cytometric immunophenotyping forms the basis of modern classification of acute and chronic leukemias and is increasingly applied for initial diagnostic work-up of non-Hodgkin's lymphomas. Finally, with multiparameter flow cytometry, it is now possible to identify routinely and reliably low numbers of leukemia and lymphoma cells (minimal residual disease).<\/jats:p><jats:p>Clin Chem Lab Med 2006;44:775\u201396.<\/jats:p>","DOI":"10.1515\/cclm.2006.146","type":"journal-article","created":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T10:12:32Z","timestamp":1150452752000},"source":"Crossref","is-referenced-by-count":50,"title":["Flow-cytometric immunophenotyping of normal and malignant lymphocytes"],"prefix":"10.1515","volume":"44","author":[{"given":"Tomasz","family":"Szczepa\u0144ski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent H.J.","family":"van der Velden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques J.M.","family":"van Dongen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref1281","first-page":"121","article-title":"van Dongen Szczepan ski de Bruijn MAC Van den Beemd de Bruin - Detection of minimal residual disease in acute leuke - mia patients","volume":"132","author":"Versteeg","year":"1996","journal-title":"Cytokines Mol Ther"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/(SICI)1097-0320(19980215)34:1<22::AID-CYTO4>3.0.CO;2-G","article-title":"Age - related changes of lymphocyte subsets in normal bone marrow biopsies","volume":"40","author":"Rego","year":"1998","journal-title":"Cytometry"},{"key":"ref831","first-page":"2257","article-title":"van Dongen Design and stan - dardization of PCR primers and protocols for detection of clonal immunoglobulin and cell receptor gene recombinations in suspect lymphoproliferations : Report of the BIOMED - Concerted Action BMH CT","volume":"86","author":"Langerak","year":"2003","journal-title":"Leukemia"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1182\/blood.V89.9.3104","article-title":"Lack of expression of Thy - CD on acute myeloid leukemia cells with long - term proliferative ability in vitro and in vivo","volume":"12","author":"Blair","year":"1997","journal-title":"Blood"},{"key":"ref1151","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1182\/blood.V97.7.2115","article-title":"Identification of novel markers for mon - itoring minimal residual disease in acute lymphoblastic leukemia","volume":"119","author":"Chen","year":"2001","journal-title":"Blood"},{"key":"ref1071","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1038\/sj.leu.2403478","article-title":"Comparative analysis of minimal residual disease detection using four - color flow cyto - metry consensus IgH - PCR and quantitative IgH PCR in CLL after allogeneic and autologous stem cell trans - plantation","volume":"111","author":"Bottcher","year":"2004","journal-title":"Leukemia"},{"key":"ref531","first-page":"1141","article-title":"van der Burg van Wering ER Lan - gerak Szczepan ski van Dongen The presence of somatic mutations in immunoglobulin genes of cell acute lymphoblastic leukemia ( ALL - L supports assign - ment as Burkitt s leukemia - lymphoma rather than line - age ALL","volume":"55","author":"Barendregt","year":"2001","journal-title":"Leukemia"},{"key":"ref651","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1056\/NEJMoa023143","article-title":"ZAP - expression as a surrogate for immunoglobulin - variable - region mutations in chronic lymphocytic leukemia","volume":"68","author":"Crespo","year":"2003","journal-title":"Engl J Med"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1182\/blood.V82.4.1086.1086","article-title":"Predictability of the t ( q p from surface antigen phenotype : implications for screening cases of childhood acute lymphoblastic leukemia for molecular analysis : a Pediatric Oncology Group study","volume":"60","author":"Borowitz","year":"1993","journal-title":"Blood"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1084\/jem.177.5.1331","article-title":"Expression of Thy - on human hematopoietic progenitor cells","volume":"14","author":"Craig","year":"1993","journal-title":"J Exp Med"},{"key":"ref1131","first-page":"688","article-title":"Van Lochem van den Beemd Hah - len van Dongen Regeneration pat - tern of precursor - cells in bone marrow of acute lymphoblastic leukemia patients depends on the type of preceding chemotherapy","volume":"117","author":"Wiegers","year":"2000","journal-title":"Leukemia"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/sj.leu.2401364","article-title":"A limited anti - body panel can distinguish precursor acute lympho - blastic leukemia from normal B precursors with four color flow cytometry : implications for residual disease detec - tion","volume":"4","author":"Weir","year":"1999","journal-title":"Leukemia"},{"key":"ref771","first-page":"187","article-title":"San Miguel Sanchez - Guijo Immunophenotypic analysis of Waldenstrom s macroglobulinemia","volume":"80","author":"Vidriales","year":"2003","journal-title":"Semin Oncol"},{"key":"ref1001","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0140-6736(97)10295-1","article-title":"Coustan Immunological detec - tion of minimal residual disease in children with acute lymphoblastic leukaemia","volume":"104","author":"Smith","year":"1998","journal-title":"Lancet"},{"key":"ref791","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1182\/blood-2001-12-0297","article-title":"Pat - more Flow cytometric disease monitoring in multiple myeloma : the relationship between normal and neoplastic plasma cells pre - dicts outcome after transplantation","volume":"82","author":"Rawstron","year":"2002","journal-title":"Blood"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1203\/00006450-200202000-00007","article-title":"de Bruin - Comans - Bitter de Groot Composi - tion of precursor cell compartment in bone marrow from patients with linked agammaglobulinemia compared with healthy children","volume":"20","author":"Noordzij","year":"2002","journal-title":"Pediatr Res"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nature03725","article-title":"Regulation of immunity by self - reactive T cells","volume":"38","author":"Kronenberg","year":"2005","journal-title":"Nature"},{"key":"ref1251","first-page":"1845","article-title":"van der Sluijs - Gelling van der Velden van Wering ER Immunophenotypic modulation in childhood precursor - ALL can be mim - icked in vitro and is related to the induction of cell death","volume":"129","author":"Roeffen","year":"2005","journal-title":"Leukemia"},{"key":"ref1321","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1182\/blood.V98.1.29","article-title":"Rich - ards Quantitation of minimal dis - ease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the predic - tion of outcome and can be used to optimize therapy","volume":"136","author":"Rawstron","year":"2001","journal-title":"Blood"},{"key":"ref991","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1038\/sj.leu.2403135","article-title":"van der Velden Grim - wade Standardization and qual - ity control studies of real - time quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia a Europe Against Cancer program","volume":"103","author":"Gabert","year":"2003","journal-title":"Leukemia"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0167-5699(00)01596-6","article-title":"Natural cytotoxicity receptors that trigger human NK - cell - mediated cytolysis","volume":"28","author":"Moretta","year":"2000","journal-title":"Immunol Today"},{"key":"ref1231","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1038\/sj.leu.2403001","article-title":"Minimal residual dis - ease detection in childhood precursor - cell acute lym - phoblastic leukemia : relation to other risk factors A Children s Oncology Group study","volume":"127","author":"Borowitz","year":"2003","journal-title":"Leukemia"},{"key":"ref661","first-page":"1640","article-title":"The immunological profile of cell disorders and proposal of a scoring system for the diagnosis of CLL","volume":"69","author":"Matutes","year":"1994","journal-title":"Leukemia"},{"key":"ref181","first-page":"19","article-title":"Four - color flow cytometric investigation of terminal deoxynucleotidyl transferase - positive lymphoid precur - sors in pediatric bone marrow : CD a expression pre - cedes CD in early cell ontogeny","volume":"19","author":"Dworzak","year":"1998","journal-title":"Blood"},{"key":"ref901","first-page":"936","article-title":"Large granular lymphocy - tosis","volume":"94","author":"Zambello","year":"1998","journal-title":"Haematologica"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/1097-0320(20001015)42:5<296::AID-CYTO7>3.0.CO;2-X","article-title":"Contribution of flow cytometric immuno - phenotyping to the evaluation of tissues with suspected lymphoma","volume":"72","author":"Dunphy","year":"2000","journal-title":"Cytometry"},{"key":"ref1291","first-page":"7","article-title":"Porwit van Lochem EG BIOMED - concerted action report : flow cytometric characterization of CD q cell subsets in normal bone marrow as a basis for the diagnosis and follow - up of T cell acute lymphoblastic leukemia ( ALL )","volume":"133","author":"MacDonald","year":"2000","journal-title":"Leukemia"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.4049\/jimmunol.168.5.2083","article-title":"Reference : CD Antigens","volume":"8","author":"Mason","year":"2002","journal-title":"J Immunol"},{"key":"ref1011","first-page":"1731","article-title":"van Dongen Panzer - Grumayer Prognostic val - ue of minimal residual disease in acute lymphoblastic leukaemia in childhood","volume":"105","author":"Seriu","year":"1998","journal-title":"Lancet"},{"key":"ref721","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/(SICI)1097-0320(19961001)25:2<113::AID-CYTO1>3.0.CO;2-I","article-title":"Flow cytometric immunophenotyping of non - Hodgkin s lymphomas and related disorders","volume":"75","author":"Tbakhi","year":"1996","journal-title":"Cytometry"},{"key":"ref851","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1182\/blood-2002-12-3898","article-title":"Della Expression and function of KIR and natural cytotoxicity receptors in NK - type lympho - proliferative diseases of granular lymphocytes ( LDGL )","volume":"89","author":"Zambello","year":"2003","journal-title":"Blood"},{"key":"ref941","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1365-2141.2001.03038.x","article-title":"Differentiation stage of natural killer cell - lineage lymphoproliferative disorders based on phenotypic analysis Br","volume":"98","author":"Mori","year":"2001","journal-title":"Haematol"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.4049\/jimmunol.136.12.4480","article-title":"The relationship of CD Leu - and Leu - NKH - anti - gen expression on human peripheral blood NK cells and cytotoxic T lymphocytes","volume":"26","author":"Lanier","year":"1986","journal-title":"J Immunol"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1365-2249.1999.00850.x","article-title":"Schwartz - Albiez Age - dependent altered proportions in sub - populations of tonsillar lymphocytes","volume":"44","author":"Bergler","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"ref1161","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1309\/X5VV6FKJQ6MUBLPX","article-title":"CD expression decreases as nonmalignant B cells mature in bonemar - row and is frequently overexpressed in adult and pedi - atric precursor cell acute lymphoblastic leukemia","volume":"120","author":"Lee","year":"2005","journal-title":"Am J Clin Pathol"},{"key":"ref701","first-page":"2","article-title":"Flow cytometric immunophenotyping including Bcl - detection on fine needle aspirates in the diagnosis of reactive lymphadenopathy and non - Hodg - kin s lymphoma","volume":"73","author":"Laane","year":"2005","journal-title":"Cytometry Clin Cytom"},{"key":"ref401","first-page":"25","article-title":"Lymphocyte populations in human lymph nodes Alterations in CD qCD q T reg - ulatory cell phenotype and cell receptor Vb repertoire","volume":"42","author":"Battaglia","year":"2003","journal-title":"Immunology"},{"key":"ref811","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1182\/blood.V98.1.165","article-title":"van Den Beemd Wolvers - IL Boor van Lochem EG Molecular and flow cytometric analysis of the Vb repertoire for clo - nality assessment in mature TCRab cell proliferations","volume":"84","author":"Langerak","year":"2001","journal-title":"Blood"},{"key":"ref311","first-page":"5","article-title":"CD expression in human B - cell populations","volume":"33","author":"Youinou","year":"1999","journal-title":"Immunol Today"},{"key":"ref871","first-page":"354","article-title":"EORTC classification for primary cuta - neous lymphomas : a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer","volume":"91","author":"Willemze","year":"1997","journal-title":"Blood"},{"key":"ref1111","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1182\/blood.V85.6.1416.bloodjournal8561416","article-title":"Pui CH Detection of minimal residual dis - ease in acute leukemia : methodologic advances and clinical significance","volume":"115","author":"Campana","year":"1995","journal-title":"Blood"},{"key":"ref451","first-page":"3835","article-title":"Muller - Her - melink The World Health Organi - zation classification of neoplastic diseases of the hematopoietic and lymphoid tissues : report of the Clin - ical Advisory Committee meeting Airlie House Virgin - ia November","volume":"47","author":"Harris","year":"1997","journal-title":"J Clin Oncol"},{"key":"ref581","first-page":"1225","article-title":"De Zen Quantitative multiparametric immu - nophenotyping in acute lymphoblastic leukemia : correlation with specific genotype ETV AML ALLs identification","volume":"61","author":"Orfao","year":"2000","journal-title":"Leukemia"},{"key":"ref981","first-page":"1013","article-title":"van der Velden Szcze - pan ski van Dongen Detection of mini - mal residual disease in hematologic malignancies by real - time quantitative PCR : principles approaches and laboratory aspects","volume":"102","author":"Hochhaus","year":"2003","journal-title":"Leukemia"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jaci.2004.10.031","article-title":"de Haas Comans - BitterWM van Dongen Age - related changes in the cellular composition of the thymus in children","volume":"46","author":"Weerkamp","year":"2005","journal-title":"Allergy Clin Immunol"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/modpathol.3800141","article-title":"Flow cytometric analysis of normal and reactive spleen","volume":"45","author":"Colovai","year":"2004","journal-title":"Mod Pathol"},{"key":"ref1141","first-page":"139","article-title":"van Wering ER van der Linden - Schrever BE Szcze - pan ski van Wijngaarde - Schmitz Regenerating normal cell pre - cursors during and after treatment of acute lympho - blastic leukaemia : implications for monitoring of mini - mal residual disease Br","volume":"118","author":"Willemse","year":"2000","journal-title":"Haematol"},{"key":"ref321","first-page":"27","article-title":"CD : a memory cell marker","volume":"34","author":"Agematsu","year":"2000","journal-title":"Immunol Today"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/sj.emboj.7600019","article-title":"Unravelling natural killer cell func - tion : triggering and inhibitory human NK receptors","volume":"27","author":"Moretta","year":"2004","journal-title":"EMBO J"},{"key":"ref1331","first-page":"467","article-title":"- Garcia Incidence of phe - notypic aberrations in a series of patients with B chronic lymphoproliferative disorders : basis for the design of specific four - color stainings to be used for minimal residual disease investigation","volume":"137","author":"Sanchez","year":"2002","journal-title":"Leukemia"},{"key":"ref341","first-page":"4","article-title":"CD q Tregs and immune con - trol","volume":"36","author":"Fehervari","year":"2004","journal-title":"J Clin Invest"},{"key":"ref1311","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1038\/sj.leu.2400835","article-title":"Catovsky Analysis of residual disease in chronic lym - phocytic leukemia by flow cytometry","volume":"135","author":"Cabezudo","year":"1997","journal-title":"Leukemia"},{"key":"ref151","first-page":"1","article-title":"Immunologic classification of leuke - mia and lymphoma","volume":"16","author":"Foon","year":"1986","journal-title":"Blood"},{"key":"ref971","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/(SICI)1097-0320(19990815)38:4<139::AID-CYTO1>3.0.CO;2-H","article-title":"Detection of minimal residual disease in acute leukemia by flow cytometry","volume":"101","author":"Campana","year":"1999","journal-title":"Cytometry"},{"key":"ref171","first-page":"49","article-title":"de Vries van Dongen Antigen receptors on T and B lym - phocytes : parallels in organization and function Immu - nol","volume":"18","author":"Borst","year":"1993","journal-title":"Rev"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/(SICI)1097-0320(19990501)36:1<36::AID-CYTO5>3.0.CO;2-9","article-title":"Nine - color eleven - parameter immuno - phenotyping using three laser flow cytometry","volume":"5","author":"Bigos","year":"1999","journal-title":"Cytometry"},{"key":"ref1301","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/sj.leu.2403303","article-title":"CD expression in lineage ALL : impli - cations for flow cytometric detection of minimal resid - ual disease","volume":"134","author":"Dworzak","year":"2004","journal-title":"Leukemia"},{"key":"ref501","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cyto.b.20075","article-title":"Del Poeta Normal lymphocytes from leukemic samples as an internal quality control for fluorescence intensity in immunophenotyping of acute leukemias","volume":"52","author":"Ratei","year":"2006","journal-title":"Cytometry B"},{"key":"ref711","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1182\/blood.V89.6.2067","article-title":"Gas - coyne Mantle cell lymphoma : a clinicopathologic study of cases","volume":"74","author":"Argatoff","year":"1997","journal-title":"Blood"},{"key":"ref1061","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1038\/sj.leu.2401559","article-title":"Clinical rel - evance of minimal residual disease monitoring in non - Hodgkin s lymphomas : a critical reappraisal of molecular strategies","volume":"110","author":"Corradini","year":"1999","journal-title":"Leukemia"},{"key":"ref291","first-page":"388","article-title":"Comans - Bitter de Groot van den Beemd Nei - jens Hop WC Immunopheno - typing of blood lymphocytes in childhood Reference values for lymphocyte subpopulations","volume":"31","author":"Groeneveld","year":"1997","journal-title":"J Pediatr"},{"key":"ref891","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1182\/blood.V89.1.256","article-title":"Loughran TP The lymphoproliferative disease of granular lymphocytes : updated criteria for diagnosis","volume":"93","author":"Semenzato","year":"1997","journal-title":"Blood"},{"key":"ref1121","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1046\/j.1365-2141.2003.04393.x","article-title":"Determination of minimal residual disease in leukaemia patients Br","volume":"116","author":"Campana","year":"2003","journal-title":"Haematol"},{"key":"ref951","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1182\/blood.V88.11.4265.bloodjournal88114265","article-title":"Hepatosplenic cell lym - phoma : a distinct clinicopathologic entity of cytotoxic gamma delta cell origin","volume":"99","author":"Cooke","year":"1996","journal-title":"Blood"},{"key":"ref801","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/sj.leu.2400907","article-title":"van Dongen van Lom Misere van der Heul Induction of clinical remission in large granular lymphocyte leukemia with cyclospo - rin monitored by use of immunophenotyping with Vb antibodies","volume":"83","author":"Brinkman","year":"1998","journal-title":"Leukemia"},{"key":"ref1031","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1182\/blood.V99.6.1952","article-title":"Prognostic significance and modalities of flow cytometric minimal residual disease detection in childhood acute lymphoblastic leukemia","volume":"107","author":"Dworzak","year":"2002","journal-title":"Blood"},{"key":"ref751","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1200\/JCO.2000.18.3.510","article-title":"Molecular and clinical features of non - Burkitt s diffuse large - cell lymphoma of cell type asso - ciated with the c - MYC immunoglobulin heavy - chain fusion gene","volume":"78","author":"Akasaka","year":"2000","journal-title":"J Clin Oncol"},{"key":"ref1201","first-page":"305","article-title":"Comparative phenotypemapping of normal vs malignant pediatric lymphopoiesis unveils leukemia - associated aberrations","volume":"124","author":"Dworzak","year":"1998","journal-title":"Exp Hematol"},{"key":"ref1261","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/cyto.b.20071","article-title":"Comparison of diagnostic and relapse flow cytometry phenotypes in childhood acute lympho - blastic leukemia : implications for residual disease detection : a report from the children s oncology group Cytometry","volume":"130","author":"Borowitz","year":"2005","journal-title":"Clin Cytom"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1182\/blood.V90.12.5002","article-title":"Oga - wa AC a novel marker for human hematopoietic stem and progenitor cells","volume":"15","author":"Yin","year":"1997","journal-title":"Blood"},{"key":"ref521","first-page":"1783","article-title":"Proposals for the immunological classifi - cation of acute leukemias European Group for the Immunological Characterization of Leukemias ( EGIL )","volume":"54","author":"Bene","year":"1995","journal-title":"Leukemia"},{"key":"ref1021","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/sj.leu.2403283","article-title":"Coustan Clinical significance of minimal residual disease in childhood acute lymphoblastic leu - kemia after first relapse","volume":"106","author":"Smith","year":"2004","journal-title":"Leukemia"},{"key":"ref1051","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1182\/blood-2002-08-2613","article-title":"- Minimal residual disease in adolescent ( older than years ) and adult acute lym - phoblastic leukemias : early immunophenotypic evalu - ation has high clinical value","volume":"109","author":"Vidriales","year":"2003","journal-title":"Blood"},{"key":"ref51","first-page":"200","article-title":"Flow cytometric analysis of human bone marrow IV Differential quantitative expres - sion of - common leukocyte antigen during normal hemopoiesis","volume":"6","author":"Shah","year":"1988","journal-title":"J Immunol"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1182\/blood-2002-08-2438","article-title":"Le Tutour Analysis of TCR pT alpha and RAG - in acute lymphoblastic leukemias improves understanding of early human lymphoid lineage com - mitment","volume":"64","author":"Asnafi","year":"2003","journal-title":"Blood"},{"key":"ref1101","first-page":"47","article-title":"van Dongen Hooijkaas Detection of minimal residual disease in acute leukemia by immunological marker analysis and polymerase chain reaction","volume":"114","author":"Breit","year":"1992","journal-title":"Leukemia"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1046\/j.0902-4441.2003.00199.x","article-title":"Ref - erence values for peripheral blood lymphocyte pheno - types applicable to the healthy adult population in Switzerland","volume":"30","author":"Bisset","year":"2004","journal-title":"Eur J Haematol"},{"key":"ref1211","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1200\/JCO.1998.16.12.3774","article-title":"San Miguel - Prognostic value of immunophenotypic detection of minimal residual dis - ease in acute lymphoblastic leukemia","volume":"125","author":"Ciudad","year":"1998","journal-title":"J Clin Oncol"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/S0140-6736(05)74231-8","article-title":"Deficiency of a subset of cells with immunoregu - latory properties in sarcoidosis","volume":"37","author":"Ho","year":"2005","journal-title":"Lancet"},{"key":"ref161","first-page":"298","article-title":"van Dongen Immuno - phenotyping of leukaemias and non - Hodgkin s lympho - mas Immunological markers and their CD codes Neth","volume":"17","author":"Adriaansen","year":"1988","journal-title":"J Med"},{"key":"ref21","first-page":"1","article-title":"Revised guideline on immunophenotyping in acute leukaemias and chronic lymphoproliferative disorders Lab Hae - matol","volume":"3","author":"Bain","year":"2002","journal-title":"Clin"},{"key":"ref391","first-page":"1","article-title":"van Lochem EG van der Velden te Mar - velde JG Westerdaal NA van Dongen Immunophe - notypic differentiation patterns of normal hematopoiesis in human bone marrow : reference patterns for age - relat - ed changes and disease - induced shifts","volume":"41","author":"Wind","year":"2004","journal-title":"Cytometry"},{"key":"ref1241","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/sj.leu.2403559","article-title":"Drug - induced immunophenotypic modulation in childhood ALL : implications for minimal residual dis - ease detection","volume":"128","author":"Gaipa","year":"2005","journal-title":"Leukemia"},{"key":"ref1271","first-page":"1523","article-title":"van Wering ER van der Lin - den - Schrever BE Immunophenotypic changes between diagnosis and relapse in childhood acute lymphoblastic leukemia","volume":"131","author":"Beishuizen","year":"1995","journal-title":"Leukemia"},{"key":"ref411","first-page":"539","article-title":"CD expression in follicular lymphoma and large cell lymphoma is dif - ferent from that of reactive lymph node follicles Arch","volume":"43","author":"Almasri","year":"1998","journal-title":"Pathol Lab Med"},{"key":"ref371","first-page":"11","article-title":"dos Anjos Teixeira The ex vivo patterns of CD CD CD CD c CD CD b CD CD RO and CD a \/ HLA - DR expression identify acute \/ early and chronic \/ late NK - cell activation states","volume":"39","author":"Lima","year":"2002","journal-title":"Blood Cells Mol Dis"},{"key":"ref491","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/(SICI)1097-0320(19971015)30:5<236::AID-CYTO4>3.0.CO;2-F","article-title":"Picker US - Canadian Consensus recommenda - tions on the immunophenotypic analysis of hematologic neoplasia by flow cytometry : data analysis and interpre - tation","volume":"51","author":"Borowitz","year":"1997","journal-title":"Cytometry"},{"key":"ref1181","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/sj.leu.2401279","article-title":"van den Beemd van Lochem EG van Wering Flow cytometric anal - ysis of normal B cell differentiation : a frame of refer - ence for the detection of minimal residual disease in precursor - ALL","volume":"122","author":"Lucio","year":"1999","journal-title":"Leukemia"},{"key":"ref11","first-page":"675","article-title":"De Zen New methodologic approaches for immunophenotyping acute leukemias","volume":"2","author":"Basso","year":"2001","journal-title":"Haematologica"},{"key":"ref961","first-page":"409","article-title":"Szczepan ski van der Velden San Miguel van Dongen Minimal residual disease in leukae - mia patients","volume":"100","author":"Orfao","year":"2001","journal-title":"Lancet Oncol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1182\/blood-2005-03-1338","article-title":"CD molecules : human cell differ - entiation molecules","volume":"9","author":"Zola","year":"2005","journal-title":"Blood"},{"key":"ref741","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1182\/blood.V92.9.3152","article-title":"van Krieken Clinical relevance of BCL BCL and MYC rearrangements in diffuse large cell lympho - ma","volume":"77","author":"Kramer","year":"1998","journal-title":"Blood"},{"key":"ref911","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cyto.b.20063","article-title":"Flow cytometric immunophenotypic profiles of mature gamma delta cell malignancies involving peripheral blood and bone marrow Cyto - metry","volume":"95","author":"Ahmad","year":"2005","journal-title":"Clin Cytom"},{"key":"ref121","first-page":"133","article-title":"Expression of AC and CD on candidate normal stem cell populations in childhood cell precursor acute lymphoblastic leukaemia Br","volume":"13","author":"Baersch","year":"1999","journal-title":"Haematol"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.coi.2004.07.010","article-title":"Killer immunoglobulin - like recep - tors","volume":"29","author":"Moretta","year":"2004","journal-title":"Curr Opin Immunol"},{"key":"ref331","first-page":"4","article-title":"Baecher Hafler DA CD q CD high regulatory cells in human peripheral blood","volume":"35","author":"Allan","year":"2001","journal-title":"J Immunol"},{"key":"ref731","first-page":"509","article-title":"De Leval Variability in immunophenotype in diffuse large cell lymphoma and its clinical rele - vance","volume":"76","author":"Harris","year":"2003","journal-title":"Histopathology"},{"key":"ref931","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.4049\/jimmunol.152.6.2860","article-title":"- IL van Dongen Unique selection determinant in polyclonal V delta - J delta junctional regions of human peripheral gamma delta T lymphocytes","volume":"97","author":"Breit","year":"1994","journal-title":"J Immunol"}],"container-title":["Clinical Chemistry and Laboratory Medicine (CCLM)"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/cclm.2006.44.issue-7\/cclm.2006.146\/cclm.2006.146.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2006.146\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T19:06:24Z","timestamp":1683486384000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2006.146\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,1]]},"references-count":98,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.1515\/cclm.2006.146","relation":{},"ISSN":["1434-6621","1437-4331"],"issn-type":[{"value":"1434-6621","type":"print"},{"value":"1437-4331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,1]]}}}