{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T22:45:39Z","timestamp":1648507539596},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>: Since atherosclerosis is a slowly progressive process at a young age, effective preventive measures should be taken early in life to prevent future events associated with cardiovascular disease.<\/jats:p><jats:p>: The study population comprised 132 young Japanese adults (mean age 21.4\u00a0years, range 18\u201331 years). We screened plasma total homocysteine and serum folate levels and evaluated mean carotid intima-media thickness and cardio-ankle vascular index.<\/jats:p><jats:p>: Multiple regression analysis after adjustment for age and sex revealed that only folate levels were significantly correlated with plasma total homocysteine levels (\u03b2=\u20130.37, p=0.028). Carotid intima-media thickness adjusted for age and sex and compared between quintiles of total homocysteine levels was significantly increased in the highest quintile compared with other quintiles. Cardio-ankle vascular index increased with age in both women and men, but no additional determinants were identified in young adults.<\/jats:p><jats:p>: Serum folate is an independent determinant of plasma total homocysteine levels, and mild hyperhomocysteinemia may represent a risk factor for increased carotid intima-media thickness, even in young adults. Comprehensive health education from the early period of life, including the suggestion of appropriate dietary measures, is important for effective prevention of future atherosclerosis.<\/jats:p><jats:p>Clin Chem Lab Med 2007;45:220\u20135.<\/jats:p>","DOI":"10.1515\/cclm.2007.047","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T08:02:46Z","timestamp":1172044966000},"source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of cardiovascular risk factors and related clinical markers in healthy young Japanese 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