{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:28:40Z","timestamp":1757701720736},"reference-count":76,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite substantial evidence indicating the association of hyperhomocysteinemia (hHcys) and end-stage renal disease (ESRD), the pathogenic role of increased plasma homocysteine (Hcys) levels in the progression of ESRD remains unclear. This review will briefly summarize recent findings regarding the role of hHcys in the development of glomerulosclerosis, the association of hHcys with reduced renal transsulfuration and Hcys-induced changes of redox signaling in the development of glomerulosclerosis in rat kidneys. Based on these results, it is concluded that hHcys is implicated in glomerular sclerosis in hypertension, elevated plasma Hcys in Dahl salt-sensitive (SS) hypertensive rats is due to downregulation of cystathionine \u03b2-synthase (CBS) expression and consequent abnormality of transsulfuration in the kidney compared with normotensive rats. Hcys-induced superoxide (O<\/jats:p><jats:p>Clin Chem Lab Med 2007;45:1688\u201393.<\/jats:p>","DOI":"10.1515\/cclm.2007.344","type":"journal-article","created":{"date-parts":[[2007,11,8]],"date-time":"2007-11-08T20:09:44Z","timestamp":1194552584000},"source":"Crossref","is-referenced-by-count":5,"title":["Hyperhomocysteinemia \u2013 association with renal transsulfuration and redox signaling in rats"],"prefix":"10.1515","volume":"45","author":[{"given":"Li","family":"Pin-Lan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ningjun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.277.22.1775"},{"key":"p_2","first-page":"367","volume":"52","author":"Herrmann W","year":"2006","journal-title":"Clin Lab"},{"key":"p_3","doi-asserted-by":"crossref","first-page":"1726S","DOI":"10.1093\/jn\/136.6.1726S","volume":"136","author":"Selhub J","year":"2006","journal-title":"J Nutr"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00825.x"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1161\/hy02t2.102992"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.63.s84.33.x"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001517"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1159\/000101471"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00825.x"},{"key":"p_10","first-page":"111","volume":"56","author":"McCully KS","year":"1969","journal-title":"Am J Pathol"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1139\/y05-047"},{"key":"p_12","first-page":"279","volume":"32","author":"Ozmen B","year":"2002","journal-title":"Ann Clin Lab Sci"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00732.x"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00795.x"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(00)00193-5"},{"key":"p_16","first-page":"279","volume":"32","author":"Ozmen B","year":"2002","journal-title":"Ann Clin Lab Sci"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.36323"},{"key":"p_19","first-page":"2382","author":"Mitch WE","year":"1996","journal-title":"Philadelphia, PA: WB Saunders Company"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.1007\/s003800070030"},{"key":"p_21","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.298"},{"key":"p_22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/ajcn\/72.2.315","volume":"72","author":"Brattstrom L","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"p_23","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2571(98)00029-6"},{"key":"p_24","doi-asserted-by":"crossref","first-page":"1295S","DOI":"10.1093\/jn\/126.suppl_4.1295S","volume":"126","author":"Dudman NP","year":"1996","journal-title":"J Nutr"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014300"},{"key":"p_26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/bj3280287","volume":"328","author":"House JD","year":"1997","journal-title":"Biochem J"},{"key":"p_27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00144.x"},{"key":"p_28","first-page":"1","volume":"61","author":"McCully KS","year":"1970","journal-title":"Am J Pathol"},{"key":"p_29","first-page":"181","volume":"59","author":"McCully KS","year":"1970","journal-title":"Am J Pathol"},{"key":"p_30","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(75)90004-0"},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(90)90165-F"},{"key":"p_32","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199004000-00001"},{"key":"p_33","first-page":"134","volume":"24","author":"McCully KS","year":"1994","journal-title":"Ann Clin Lab Sci"},{"key":"p_34","first-page":"27","volume":"24","author":"McCully KS","year":"1994","journal-title":"Ann Clin Lab Sci"},{"key":"p_35","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.49.1.31"},{"key":"p_36","doi-asserted-by":"publisher","DOI":"10.1001\/jama.274.13.1049"},{"key":"p_37","first-page":"3805","volume":"96","author":"Brattstrom L","year":"1997","journal-title":"Circulation"},{"key":"p_38","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1055\/s-0037-1614070","volume":"84","author":"de Franchis R","year":"2000","journal-title":"Thromb Haemost"},{"key":"p_39","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V101.7.2483"},{"key":"p_40","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00739-5"},{"key":"p_41","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00297-X"},{"key":"p_42","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/ajcn\/64.4.587","volume":"64","author":"Lussier-Cacan S","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"p_43","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/ajcn\/59.4.940","volume":"59","author":"Pancharuniti N","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"p_44","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00271-8"},{"key":"p_45","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2002.122862"},{"key":"p_46","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8467"},{"key":"p_47","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1055\/s-0038-1657636","volume":"78","author":"van der Molen EF","year":"1997","journal-title":"Thromb Haemost"},{"key":"p_48","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041460108"},{"key":"p_49","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1996.137273.x"},{"key":"p_50","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(95)05529-6"},{"key":"p_51","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014303"},{"key":"p_52","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2003.217"},{"key":"p_53","first-page":"S72","volume":"41","author":"Chauveau P","year":"1993","journal-title":"Kidney Int Suppl"},{"key":"p_54","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1093\/clinchem\/36.12.2137","volume":"36","author":"Soria C","year":"1990","journal-title":"Clin Chem"},{"key":"p_55","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199602150-00034"},{"key":"p_56","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00624.x"},{"key":"p_57","first-page":"44","volume":"54","author":"Moustapha A","year":"1999","journal-title":"Geriatrics"},{"key":"p_58","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.1998.032"},{"key":"p_59","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.0550031028.x"},{"key":"p_60","first-page":"230","volume":"40","author":"Hultberg B","year":"1993","journal-title":"Clin Nephrol"},{"key":"p_61","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.1.142"},{"key":"p_62","doi-asserted-by":"publisher","DOI":"10.1159\/000063100"},{"key":"p_63","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1999.0519"},{"key":"p_64","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000219634.83928.6e"},{"key":"p_65","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1161\/01.HYP.37.2.456","volume":"37","author":"Cowley","year":"2001","journal-title":"Hypertension"},{"key":"p_66","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2003.10.033"},{"key":"p_67","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000129182.46440.4a"},{"key":"p_68","doi-asserted-by":"publisher","DOI":"10.1086\/321262"},{"key":"p_69","doi-asserted-by":"crossref","first-page":"F1111","DOI":"10.1152\/ajprenal.00218.2001","volume":"282","author":"Li N","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"p_70","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/01.HYP.37.2.547","volume":"37","author":"Zou AP","year":"2001","journal-title":"Hypertension"},{"key":"p_71","doi-asserted-by":"publisher","DOI":"10.1046\/j.0001-6772.2003.01206.x"},{"key":"p_72","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00968.x"},{"key":"p_73","doi-asserted-by":"publisher","DOI":"10.1139\/y05-136"},{"key":"p_74","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-005991"},{"key":"p_75","doi-asserted-by":"publisher","DOI":"10.1385\/CT:5:1:009"},{"key":"p_76","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00548.2005"},{"key":"p_77","first-page":"A39","volume":"45","author":"Chen QZ","year":"2004","journal-title":"Clin Chem Lab Med"}],"container-title":["Clinical Chemical Laboratory Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2007.344\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T22:51:44Z","timestamp":1619045504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2007.344\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,1]]},"references-count":76,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.1515\/cclm.2007.344","relation":{},"ISSN":["1437-4331","1434-6621"],"issn-type":[{"value":"1437-4331","type":"electronic"},{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1,1]]}}}