{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:08:49Z","timestamp":1787022529183,"version":"build-2736575974"},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>: The incidence of coronary artery disease (CAD) is increasing at an alarming rate, especially in developing countries, such as India. It is often advocated that a vegetarian lifestyle could reduce the burden of CAD. However, in spite of a majority of Indians being vegetarians, the incidence of CAD is highest in this population. This may be due to deficiency of vitamin B12, a micronutrient, sourced only from animal products.<\/jats:p>\n                  <jats:p>: Herein, we assessed the effect of vitamin B12 with respect to CAD in 816 individuals (368 CAD patients and 448 controls) recruited from a tertiary care center in New Delhi, India.<\/jats:p>\n                  <jats:p>: We found that vitamin B12 levels were significantly lower in CAD patients than in controls (p&lt;0.0001). Also, vegetarians were found to have significantly lower vitamin B12 concentrations (p=0.0001) and higher incidence of CAD (p=0.01). Interestingly, elevated homocysteine levels, a hallmark of vitamin B12 deficiency, was not associated with CAD. In contrast, cysteine levels were significantly higher in CAD patients than in controls (p=0.004).<\/jats:p>\n                  <jats:p>: We believe that, when vitamin B12 is deficient, homocysteine is rapidly metabolized via the transsulfuration pathway leading to increased cysteine levels.<\/jats:p>\n                  <jats:p>Clin Chem Lab Med 2009;47:334\u20138.<\/jats:p>","DOI":"10.1515\/cclm.2009.074","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T08:35:13Z","timestamp":1233736513000},"source":"Crossref","is-referenced-by-count":28,"title":["Vitamin B12 deficiency is associated with coronary artery disease in an Indian population"],"prefix":"10.1515","volume":"47","author":[{"given":"Jitender","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elayanambi","family":"Sundaramoorthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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