{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T08:28:56Z","timestamp":1772180936798,"version":"3.50.1"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Chemistry and Laboratory Medicine"],"published-print":{"date-parts":[[2010,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Background:<\/jats:bold> Alkaline phosphatase (ALP) is a widely used marker for skeletal and hepatobiliary disorders, but its activity is also increased in atherosclerosis and peripheral vascular disease. It is an inflammatory marker like C-reactive protein (CRP). We therefore analyzed its relationship with CRP in the United States National Health and Nutrition Examination Survey (NHANES) 2005\u20132006.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> The analysis included 4155 men and non-pregnant women over the age of 20\u00a0years. The relationship between log-transformed ALP and plasma CRP was analyzed using univariate and multivariate models.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> ALP activity was significantly correlated with age, waist circumference, body mass index, blood pressure, exercise, alcohol, triglycerides, and other liver enzymes after adjusting for age, gender and ethnicity (p&lt;0.001). ALP was significantly associated with a higher frequency of cardiovascular disease (p=0.02), hypertension (p=0.01) hypercholesterolemia (p=0.04), and diabetes (p=0.02). Compared to the lowest quartile of ALP, the adjusted odds ratio (OR) associated with the highest quartile were 1.9 [95% confidence intervals (CI) 1.1\u20133.5], 1.6 (95% CI 1.0\u20132.5), 1.5 (95% CI 1.1\u20132.1) and 1.7 (95% CI 1.0\u20132.4) for cardiovascular disease, hypertension, hypercholesterolemia, and diabetes, respectively. In multivariate analysis, log ALP was an independent predictor of log CRP (p=1.0\u00d710<jats:sup>\u22126<\/jats:sup>). A multivariate model that included log ALP, ethnicity, glycohemoglobin, waist circumference, albumin, apolipoprotein B, \u03b3-glutamyltransferase and uric acid explained 40% of the variance in log CRP.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> ALP is a marker of cardiometabolic risk, but it needs to be tested as part of a multivariate model in prospective studies.<\/jats:p>\n               <jats:p>Clin Chem Lab Med 2010;48:167\u201373.<\/jats:p>","DOI":"10.1515\/cclm.2010.052","type":"journal-article","created":{"date-parts":[[2009,12,4]],"date-time":"2009-12-04T08:41:20Z","timestamp":1259916080000},"page":"167-173","source":"Crossref","is-referenced-by-count":102,"title":["Association between serum alkaline phosphatase and C-reactive protein in the United States National Health and Nutrition Examination Survey 2005\u20132006"],"prefix":"10.1515","volume":"48","author":[{"given":"Matthew","family":"Webber","sequence":"first","affiliation":[{"name":"School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisling","family":"Krishnan","sequence":"additional","affiliation":[{"name":"School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil G.","family":"Thomas","sequence":"additional","affiliation":[{"name":"School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard M.Y.","family":"Cheung","sequence":"additional","affiliation":[{"name":"School of Clinical and Experimental Medicine, 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