{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:04:37Z","timestamp":1761609877945},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Chemistry and Laboratory Medicine"],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Background:<\/jats:bold> The goal of our study was to evaluate the diagnostic performance of the anti-cyclic citrullinated peptide 2 (anti-CCP2) assay in patients with autoimmune and inflammatory disorders.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> We tested the specificity and sensitivity of anti-CCP2 antibodies measured by ELISA in 787 patients with rheumatoid arthritis (RA), 1024 patients with other autoimmune\/inflammatory rheumatic disease and 401 subjects without autoimmune rheumatic disease. The optimal cut-off value was defined as the value with the highest diagnostic accuracy (receiver operating characteristic curve analysis). Interval-specific likelihood ratios (LRs) were calculated for each range bounded by defined anti-CCP2 values.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> To distinguish between patients with RA and controls, the cut-off value with the highest diagnostic accuracy for anti-CCP2 was 2.8\u00a0U\/mL. Comparing the optimal cut-off value for anti-CCP2 to that recommended by the manufacturer (5.0\u00a0U\/mL), an increase in prevalence between the proportions of test-positive patients was found for RA, undifferentiated connective tissue disease and undifferentiated arthritis. Evaluating interval-specific LRs for the selected ranges bound by two anti-CCP2 values, in RA and diseased controls, the LRs were 0.40 for values &lt;5.0\u00a0U\/mL, 6.66 for 5.0\u201315.0\u00a0U\/mL, 27.01 for 15.1\u201330.0\u00a0U\/mL and 28.89 for &gt;30.0\u00a0U\/mL.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> The cut-off value of 2.8\u00a0U\/mL for anti-CCP2 has the highest diagnostic accuracy. A value of anti-CCP2 &gt;15\u00a0U\/mL is associated with an increase in the likelihood of RA disease.<\/jats:p>\n               <jats:p>Clin Chem Lab Med 2010;48:829\u201334.<\/jats:p>","DOI":"10.1515\/cclm.2010.152","type":"journal-article","created":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T10:38:46Z","timestamp":1268995126000},"page":"829-834","source":"Crossref","is-referenced-by-count":15,"title":["Diagnostic performance of anti-citrullinated peptide antibodies for the diagnosis of rheumatoid arthritis: the relevance of likelihood ratios"],"prefix":"10.1515","volume":"48","author":[{"given":"Donatello","family":"Pietrapertosa","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Tolusso","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Gremese","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Concetta","family":"Papalia","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Laura","family":"Bosello","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giusy","family":"Peluso","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Catholic University of the Sacred Heart, Rome, 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