{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:18:06Z","timestamp":1761895086455},"reference-count":46,"publisher":"Walter de Gruyter GmbH","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Chemistry and Laboratory Medicine"],"published-print":{"date-parts":[[2010,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Background:<\/jats:bold> Prematurity and small-for-gestational age (SGA) neonates are at risk for postnatal complications. Concentrations of total homocysteine (tHcy) might be related to neonatal outcome. We hypothesized that concentrations of tHcy are not related to growth restriction in neonates from mothers receiving 5\u00a0mg\/day folic acid. We studied a total of 133 preterm neonates from normotensive mothers; SGA (n=96) and appropriate-for-gestational age (AGA, n=37).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> Concentrations of tHcy, folate and vitamin B12 were measured in venous umbilical cord plasma.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> AGA preterm neonates had higher mean birth weight (BW) compared to SGA preterms (2472\u00a0g vs. 2007\u00a0g; p&lt;0.001) of comparable mean gestational age (GA) (35.1 vs. 35.7\u00a0weeks; p=0.059). Concentrations of tHcy (4.86 vs. 4.95\u00a0\u03bcmol\/L), folate (63.3 vs. 55.7\u00a0nmol\/L), and vitamin B12 (409 vs. 394\u00a0pmol\/L) were not significantly different between the groups. GA was a strong positive predictor, BW was a significant negative predictor of cord plasma folate. Vitamin B12 concentration was a significant negative predictor of cord tHcy.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Concentrations of tHcy did not differ between SGA and AGA preterm neonates born to mothers supplemented with folic acid. This finding argues against a causal role for folate deficiency or increased tHcy in growth restriction.<\/jats:p>\n               <jats:p>Clin Chem Lab Med 2010;48:1157\u201361.<\/jats:p>","DOI":"10.1515\/cclm.2010.235","type":"journal-article","created":{"date-parts":[[2010,5,19]],"date-time":"2010-05-19T10:06:12Z","timestamp":1274263572000},"page":"1157-1161","source":"Crossref","is-referenced-by-count":12,"title":["Homocysteine in small-for-gestational age and appropriate-for-gestational age preterm neonates from mothers receiving folic acid supplementation"],"prefix":"10.1515","volume":"48","author":[{"given":"Thushari S.","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of General Pediatrics and Neonatology, University Children's Hospital, Faculty of Medicine, Saarland University, Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Neonatology, University Children's Hospital, Faculty of Medicine, Saarland University, Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamani H.","family":"Tennekoon","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Molecular Biology, Biotechnology, Faculty of Medicine, University of Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wimal","family":"Karandagoda","sequence":"additional","affiliation":[{"name":"Director, Castle Street Hospital for Women (Teaching), Colombo, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig","family":"Gortner","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Neonatology, University Children's Hospital, Faculty of Medicine, Saarland University, Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rima","family":"Obeid","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine, Medical School, Faculty of Medicine, Saarland University, Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2010,5,19]]},"reference":[{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2009.01010.x"},{"key":"p_3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4038\/sljch.v29i1.592","volume":"29","author":"Senanayake MP","year":"2000","journal-title":"Sri Lanka J Child Health"},{"key":"p_4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4038\/sljch.v37i3.114","volume":"37","author":"Amarasena S","year":"2008","journal-title":"Sri Lanka J Child Health"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70513-8"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-003-0486-9"},{"key":"p_7","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1471-0528.2004.00273.x","volume":"111","author":"Baschat AA","year":"2004","journal-title":"Br J Obstet Gynaecol"},{"key":"p_8","first-page":"847","volume":"64","author":"Villar J","year":"1986","journal-title":"Bull World Health Organ"},{"key":"p_9","first-page":"1055","volume":"84","author":"Lindblad B","year":"2005","journal-title":"Acta Obstet Gynecol Scand"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi815"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509288994"},{"key":"p_12","doi-asserted-by":"crossref","first-page":"1731S","DOI":"10.1093\/jn\/136.6.1731S","volume":"136","author":"Refsum H","year":"2006","journal-title":"J Nutr"},{"key":"p_13","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/ajcn\/71.4.962","volume":"71","author":"Vollset SE","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"p_14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/ajcn\/72.2.324","volume":"72","author":"Ueland PM","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"p_15","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1055\/s-0038-1657580","volume":"78","author":"Boers GJ","year":"1997","journal-title":"Thromb Haemost"},{"key":"p_16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/ajcn\/72.2.315","volume":"72","author":"Brattstr\u00f6m L","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1159\/000014143"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.032904"},{"key":"p_19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/ajcn\/82.1.133","volume":"82","author":"Obeid R","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"p_20","first-page":"663","volume":"65","author":"Kramer MS","year":"1987","journal-title":"Bull World Health Organ"},{"key":"p_21","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/ajcn\/79.4.619","volume":"79","author":"Amouzou EK","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"p_22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/07315724.2001.10719024","volume":"20","author":"Caudill MA","year":"2001","journal-title":"J Am Coll Nutr"},{"key":"p_23","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1542\/peds.108.3.624","volume":"108","author":"Monsen A-LB","year":"2001","journal-title":"Pediatrics"},{"key":"p_24","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1093\/clinchem\/39.9.1764","volume":"39","author":"Ueland PM","year":"1993","journal-title":"Clin Chem"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0798"},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.165"},{"key":"p_27","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/ajcn\/80.5.1312","volume":"80","author":"Guerra-Shinohara EM","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"p_28","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.121105"},{"key":"p_29","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.021717"},{"key":"p_30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2001.00012.x"},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70263-7"},{"key":"p_32","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-007-0667-6"},{"key":"p_33","doi-asserted-by":"publisher","DOI":"10.1373\/49.9.1476"},{"key":"p_34","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.80112"},{"key":"p_35","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2003.11.010"},{"key":"p_36","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-158949"},{"key":"p_37","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.173393"},{"key":"p_38","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)80005-7"},{"key":"p_39","first-page":"159","volume":"42","author":"Gunasekera PC","year":"1997","journal-title":"Ceylon Med J"},{"key":"p_40","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5687.16"},{"key":"p_41","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1136\/bmj.315.7111.786","volume":"315","author":"Ceesay SM","year":"1997","journal-title":"Br Med J"},{"key":"p_42","first-page":"125","volume":"302","author":"Markan S","year":"2007","journal-title":"Mol Cell Biol"},{"key":"p_43","first-page":"241","volume":"44","author":"Sood SK","year":"1975","journal-title":"Q J Med"},{"key":"p_44","first-page":"1545","volume":"54","author":"Koren G","year":"2008","journal-title":"Can Fam Physician"},{"key":"p_45","doi-asserted-by":"publisher","DOI":"10.1080\/01443610701814195"},{"key":"p_46","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)07104-5"},{"key":"p_47","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39000.486701.68"}],"container-title":["cclm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2010.235\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2010.235\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T05:06:07Z","timestamp":1680843967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/CCLM.2010.235\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,19]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,5,19]]},"published-print":{"date-parts":[[2010,8,1]]}},"alternative-id":["10.1515\/CCLM.2010.235"],"URL":"https:\/\/doi.org\/10.1515\/cclm.2010.235","relation":{},"ISSN":["1437-4331","1434-6621"],"issn-type":[{"value":"1437-4331","type":"electronic"},{"value":"1434-6621","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5,19]]}}}