{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:26:36Z","timestamp":1777415196798,"version":"3.51.4"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Chemistry and Laboratory Medicine"],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Background<\/jats:bold>: The goal of this study was to evaluate plasma D-dimer as a diagnostic marker for exclusion of suspected aortic dissection (AD).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods<\/jats:bold>: Two-hundred and sixty suspected AD patients were enrolled, including acute AD, n=107; chronic AD, n=17; acute myocardial infarction (AMI), n=70; pulmonary embolism (PE), n=18; non-ST elevation myocardial infarction (NSTEMI), n=28; and unstable angina (UA), n=20. All patients had D-dimer testing performed (Roche Diagnostics GmbH) immediately following admission.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> The D-dimer concentrations in both the acute AD group [median: 3.47; 95% confidence interval (CI): 2.43\u20134.50\u00a0\u03bcg\/mL] and chronic AD group (median: 1.09; 95% CI: 0.36\u20133.81\u00a0\u03bcg\/mL) were significantly higher than those in patients in the AMI, NSTEMI and UA groups (p=0.000), but not when compared to the PE group. One (0.8%) patient was identified in the acute AD group who presented with a low D-dimer value (0.04\u00a0\u03bcg\/mL), indicating the existence of intramural hematoma as demonstrated by CT.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> D-dimer may be used as a potential marker for suspected AD, with high sensitivity of up to 99.2% (1\/124). Regardless of the cut-off threshold selected, the sensitivity of D-dimer was unable to reach 100%. Further examinations, including imaging technology, were necessary to diagnose the suspected AD patients who had negative D-dimer result.<\/jats:p>\n               <jats:p>Clin Chem Lab Med 2010;48:1733\u20137.<\/jats:p>","DOI":"10.1515\/cclm.2010.337","type":"journal-article","created":{"date-parts":[[2010,8,13]],"date-time":"2010-08-13T10:08:33Z","timestamp":1281694113000},"page":"1733-1737","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of D-dimer in the diagnosis of suspected aortic dissection"],"prefix":"10.1515","volume":"48","author":[{"given":"Qing-kun","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-wu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Clinical Laboratory, Wuhan Asia Heart Hospital, Wuhan, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze-jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Center of Clinical Laboratory, Wuhan Asia Heart Hospital, Wuhan, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Center of Clinical Laboratory, Wuhan Asia Heart Hospital, Wuhan, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng-sheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center of Clinical Laboratory, Wuhan Asia Heart Hospital, Wuhan, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-zheng","family":"Cao","sequence":"additional","affiliation":[{"name":"Center of Clinical Laboratory, Wuhan Asia Heart Hospital, Wuhan, P.R. 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