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In common late onset AD sporadic forms (95% of all AD cases), a major genetic risk factor is the apolipoproteinE-\u025b4 (ApoE-\u025b4) alleles, and other genetic determinants have also been proposed to play causative role. This review focuses on biomarkers and subsequent changes in continuous measurement of cognitive and functional abilities in patients with mild cognitive impairment (MCI) and AD that aim to achieve a higher diagnostic accuracy for AD along with clinical assessment, neuropsychological testing and neuroimaging.<\/jats:p>","DOI":"10.1515\/cclm.2011.139","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T11:46:48Z","timestamp":1297252008000},"page":"773-778","source":"Crossref","is-referenced-by-count":10,"title":["Biomarkers in Alzheimer\u2019s disease"],"prefix":"10.1515","volume":"49","author":[{"given":"Vida","family":"Demarin","sequence":"first","affiliation":[{"name":"University Department of Neurology, University Hospital Sestre Milosrdnice, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Zavoreo","sequence":"additional","affiliation":[{"name":"University Department of Neurology, University Hospital 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