{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:53:00Z","timestamp":1753887180217,"version":"3.41.2"},"reference-count":11,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_crpm-2021-0086_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>With the increased survival of preterm neonates, thromboembolic (TE) events are increasingly being recognized due to the use of indwelling catheters. It is still debatable to treat TE with low molecular weight heparin (LMWH) or follow expectant management. Despite the safety and efficacy profile about using LMWH in adults, its use in extreme preterm neonates with TE events is limited. The therapeutic level and pharmacokinetics of LMWH in the preterm population are relatively variable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_crpm-2021-0086_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>We present a case with a severe hematoma on the left thigh following the use of LMWH, which was surgically drained and had a successful skin graft.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_crpm-2021-0086_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This case highlights the importance of early and close monitoring of injection sites in patients treated with LMWH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/crpm-2021-0086","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T01:51:27Z","timestamp":1653616287000},"source":"Crossref","is-referenced-by-count":1,"title":["Severe hematoma following the use of low molecular weight heparin in preterm neonate"],"prefix":"10.1515","volume":"11","author":[{"given":"Naveed Ur Rehman","family":"Durrani","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics , Sidra Medicine , Doha , Qatar"},{"name":"Department of Pediatrics , Weill Cornell Medicine\u00a0\u2013 Qatar , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elhindi","family":"Elfaki","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics , Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nqobile Tessa","family":"Sigola","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics , Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Tscherning","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics , Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics , Sidra Medicine , Doha , Qatar"},{"name":"Durham University , Durham , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme E.","family":"Glass","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery , Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phani Kiran","family":"Yajamanyum","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics , Sidra Medicine , Doha , Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"2023033120062523906_j_crpm-2021-0086_ref_001","unstructured":"Van Ommen, CH, Bergman, AK, Boerma, M, Donker, AE, Gouvernante, M, Hulzebos, CV, et al.. NEOCLOT: management of catheter-related venous thrombosis in preterm and term neonates [Abstract]. Res Pract Thromb Haemostasis 2021;5."},{"key":"2023033120062523906_j_crpm-2021-0086_ref_002","doi-asserted-by":"crossref","unstructured":"Fareed, J, Hoppensteadt, D, Walenga, J, Iqbal, O, Ma, Q, Jeske, W, et al.. Pharmacodynamic and pharmacokinetic properties of enoxaparin: implications for clinical practice. Clin Pharmacokinet 2003;42:1043\u201357. https:\/\/doi.org\/10.2165\/00003088-200342120-00003.","DOI":"10.2165\/00003088-200342120-00003"},{"key":"2023033120062523906_j_crpm-2021-0086_ref_003","doi-asserted-by":"crossref","unstructured":"Malowany, JI, Knoppert, DC, Chan, AK, Pepelassis, D, Lee, DS. Enoxaparin use in the neonatal intensive care unit: experience over 8 years. 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Why haematomas cause flap failure: an evidence-based paradigm. J Plast Reconstr Aesthetic Surg 2012;65:903\u201310. https:\/\/doi.org\/10.1016\/j.bjps.2011.12.014.","DOI":"10.1016\/j.bjps.2011.12.014"},{"key":"2023033120062523906_j_crpm-2021-0086_ref_007","doi-asserted-by":"crossref","unstructured":"Van Elteren, HA, Veldt, HS, Te Pas, AB, Roest, AA, Smiers, FJ, Kollen, WJ, et al.. Management and outcome in 32 neonates with thrombotic events. Int J Pediatr 2011;2011:1\u20135. https:\/\/doi.org\/10.1155\/2011\/217564.","DOI":"10.1155\/2011\/217564"},{"key":"2023033120062523906_j_crpm-2021-0086_ref_008","doi-asserted-by":"crossref","unstructured":"Van Elteren, HA, Te Pas, AB, Kollen, WJ, Walther, FJ, Lopriore, E. Severe hemorrhage after low-molecular-weight heparin treatment in a preterm neonate. 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J\u00a0Lab Clin Med 1988;112:641\u20133."},{"key":"2023033120062523906_j_crpm-2021-0086_ref_011","doi-asserted-by":"crossref","unstructured":"Sol, J, Boerma, M, Klaassen, I, Simons, S, Witjes, B, Wildschut, E, et al.. Effectiveness and safety of nadroparin therapy in preterm and term neonates with venous thromboembolism. 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