{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T19:32:36Z","timestamp":1764963156678,"version":"3.46.0"},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_crpm-2022-0018_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Gross hematuria is rare in the neonate and requires prompt etiology evaluation and intervention. This article aims to draw attention to adenovirus as a cause of hematuria in newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_crpm-2022-0018_abs_002\">\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We present the case of a newborn admitted to the neonatal unit after birth with respiratory distress. Empiric treatment with ampicillin and gentamicin was initiated. He presented a favorable clinical and laboratory course with decreasing inflammatory parameters. On day 7 gross hematuria was detected and the urinalysis revealed red blood cells, trace of proteins and leukocytes. Cefotaxime was added after urine and blood cultures. Doppler ultrasound showed bladder sediment with no signs of renal venous thrombosis and the cultures were negative. There was a progressive improvement of gross hematuria with resolution on day 16. Urine adenovirus PCR was positive and the diagnosis of adenovirus hemorrhagic cystitis was made.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_crpm-2022-0018_abs_003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adenovirus should be considered as a potential etiology if clinical symptoms and urinalysis are suggestive of infection, but the urine culture is negative and ensuring that all other possible causes of hematuria are ruled of. As far as the authors know, this is the first case report of a newborn with adenovirus hemorrhagic cystitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/crpm-2022-0018","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T02:35:27Z","timestamp":1672367727000},"source":"Crossref","is-referenced-by-count":0,"title":["Hemorrhagic adenovirus cystitis in a newborn"],"prefix":"10.1515","volume":"12","author":[{"given":"Susana M. D.","family":"Alexandre","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Pediatria\u00a0\u2013 Centro Hospitalar do Oeste , Caldas da Rainha , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina O. C. C.","family":"Matos","sequence":"additional","affiliation":[{"name":"Unidade de Nefrologia e Transplanta\u00e7\u00e3o Renal Pedi\u00e1trica, Departamento de Pediatria , Hospital de Santa Maria\u00a0\u2013 Centro Hospitalar Universit\u00e1rio Lisboa Norte , Lisbon , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana C. F.","family":"Fortunato","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Pediatria\u00a0\u2013 Centro Hospitalar do Oeste , Caldas da Rainha , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana R. M. C.","family":"Sandes","sequence":"additional","affiliation":[{"name":"Unidade de Nefrologia e Transplanta\u00e7\u00e3o Renal Pedi\u00e1trica, Departamento de Pediatria , Hospital de Santa Maria\u00a0\u2013 Centro Hospitalar Universit\u00e1rio Lisboa Norte , Lisbon , Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"2025120518324166013_j_crpm-2022-0018_ref_001","doi-asserted-by":"crossref","unstructured":"Jernigan, SM. Hematuria in the newborn. Clin Perinatol 2014;41:591\u2013603. https:\/\/doi.org\/10.1016\/j.clp.2014.05.008.","DOI":"10.1016\/j.clp.2014.05.008"},{"key":"2025120518324166013_j_crpm-2022-0018_ref_002","doi-asserted-by":"crossref","unstructured":"Emanuel, B, Aronson, N. Neonatal hematuria. Am J Dis Child 1974;128:204\u20136. https:\/\/doi.org\/10.1001\/archpedi.1974.02110270078015.","DOI":"10.1001\/archpedi.1974.02110270078015"},{"key":"2025120518324166013_j_crpm-2022-0018_ref_003","doi-asserted-by":"crossref","unstructured":"Joseph, C, Gattineni, J. Proteinuria and hematuria in the neonate. Curr Opin Pediatr 2016;28:202\u20138. https:\/\/doi.org\/10.1097\/mop.0000000000000323.","DOI":"10.1097\/MOP.0000000000000323"},{"key":"2025120518324166013_j_crpm-2022-0018_ref_004","unstructured":"Young, TE, Mangum, B. Neofax. Montvale, New Jersey: Thomson Reuters; 2020, 85\u201392:364\u201370 pp."},{"key":"2025120518324166013_j_crpm-2022-0018_ref_005","doi-asserted-by":"crossref","unstructured":"Paduch, DA. Viral lower urinary tract infections. Curr Urol Rep 2007;8:324\u201335. https:\/\/doi.org\/10.1007\/s11934-007-0080-y.","DOI":"10.1007\/s11934-007-0080-y"},{"key":"2025120518324166013_j_crpm-2022-0018_ref_006","unstructured":"Gleason, CA, Juul, SE. Avery\u2019s diseases of the newborn, 10th ed. Philadelphia: Elsevier; 2018:482\u20134, 518\u20139 pp."},{"key":"2025120518324166013_j_crpm-2022-0018_ref_007","doi-asserted-by":"crossref","unstructured":"Ronchi, A, Doern, C, Brock, E, Pugni, L, S\u00e1nchez, PJ. Neonatal adenoviral infection: a seventeen year experience and review of the literature. J Pediatr 2014;164:529\u201335. https:\/\/doi.org\/10.1016\/j.jpeds.2013.11.009.","DOI":"10.1016\/j.jpeds.2013.11.009"},{"key":"2025120518324166013_j_crpm-2022-0018_ref_008","unstructured":"Bernstein, D. Nelson textbook of pediatrics, 20th ed. Philadelphia: Elsevier; 2016:1611\u20132, 2516\u20137, 2556\u201362 pp."},{"key":"2025120518324166013_j_crpm-2022-0018_ref_009","unstructured":"Flomenberg, P, Kojaoghlanian, T. Pathogenesis, epidemiology, and clinical manifestations of adenovirus infection. In: Post, TW, editor. UpToDate. Waltham, MA: UpToDate Inc. Available from: http:\/\/www.uptodate.com [Accessed 1 Jan 2021]."},{"key":"2025120518324166013_j_crpm-2022-0018_ref_010","unstructured":"Allen, UD, Demmler-Harrison, GJ. Adenoviruses. In: Long, SS, Prober, CG, Fischer, M, editors. Principles and practice of pediatric infectious diseases, 5th ed. Philadelphia: Elsevier; 2017:5716\u201343 pp."},{"key":"2025120518324166013_j_crpm-2022-0018_ref_011","doi-asserted-by":"crossref","unstructured":"Mufson, MA, Zollar, LM, Mankad, VN, Manalo, D. Adenovirus infection in acute hemorrhagic cystitis. Am J Dis Child 1971;121:281\u20135. https:\/\/doi.org\/10.1001\/archpedi.1971.02100150055003.","DOI":"10.1001\/archpedi.1971.02100150055003"},{"key":"2025120518324166013_j_crpm-2022-0018_ref_012","unstructured":"Boyer, OG. Evaluation of gross hematuria in children. In: Post, TW, editor. UpToDate. Waltham, MA: UpToDate Inc. Available from: http:\/\/www.uptodate.com [Accessed 1 Jan 2021]."}],"container-title":["Case Reports in Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/crpm-2022-0018\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/crpm-2022-0018\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T19:05:06Z","timestamp":1764961506000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/crpm-2022-0018\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,30]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,4,27]]},"published-print":{"date-parts":[[2023,1,27]]}},"alternative-id":["10.1515\/crpm-2022-0018"],"URL":"https:\/\/doi.org\/10.1515\/crpm-2022-0018","relation":{},"ISSN":["2192-8959"],"issn-type":[{"type":"electronic","value":"2192-8959"}],"subject":[],"published":{"date-parts":[[2022,12,30]]},"article-number":"20220018"}}