{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:26:11Z","timestamp":1786368371413,"version":"build-2736575974"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_crpm-2024-0006_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Fetal dyshormonogenetic goiter is a rare condition associated with perinatal complications and sequelae in infants. Although prenatal management remains controversial, further evidence is required for optimal management.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_crpm-2024-0006_abs_002\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>A 30-year-old pregnant woman with no history of thyroid disease was referred to our hospital with polyhydramnios. Fetal ultrasonography revealed fetal goiter. Cordocentesis revealed increased thyroid-stimulating hormone (TSH) and low levels of free thyroxine 4 (fT4), which was the basis of diagnosis of fetal hypothyroidism. Intra-amniotic injections of levothyroxine were administered, resulting in a reduction in the goiter size, amount of amniotic fluid, and level of maternal TSH. The mother was euthyroid during pregnancy. The infant was delivered vaginally at full term with a normal thyroid size and no respiratory disorders except hypothyroidism. At 2 years of age, her neurodevelopment is normal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_crpm-2024-0006_abs_003\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Intra-amniotic injections of levothyroxine for\u00a0fetal hypothyroidism with massive goiter and polyhydramnios may improve perinatal outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/crpm-2024-0006","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T07:42:23Z","timestamp":1716536543000},"source":"Crossref","is-referenced-by-count":2,"title":["Massive fetal goiter treated by intra-amniotic injection of levothyroxine: a case report"],"prefix":"10.1515","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4235-6780","authenticated-orcid":false,"given":"Nami","family":"Tamura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , 2012847 Juntendo University Faculty of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , 2012847 Juntendo University Faculty of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , 2012847 Juntendo University Faculty of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpei","family":"Ishigami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , 2012847 Juntendo University Faculty of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Suganuma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , 2012847 Juntendo University Faculty of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , 2012847 Juntendo University Faculty of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Itakura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , 2012847 Juntendo University Faculty of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"2024052407212424367_j_crpm-2024-0006_ref_001","doi-asserted-by":"crossref","unstructured":"Corral, E, Reascos, M, Preiss, Y, Rompel, SM, Sepulveda, W. Treatment of fetal goitrous hypothyroidism: value of direct intramuscular L-thyroxine therapy. Prenat Diagn 2010;30:899\u2013901. https:\/\/doi.org\/10.1002\/pd.2560.","DOI":"10.1002\/pd.2560"},{"key":"2024052407212424367_j_crpm-2024-0006_ref_002","doi-asserted-by":"crossref","unstructured":"Kim, MJ, Chae, YH, Park, SY, Kim, MY. Intra-amniotic thyroxine to treat fetal goiter. Obstet Gynecol Sci 2016;59:66\u201370. https:\/\/doi.org\/10.5468\/ogs.2016.59.1.66.","DOI":"10.5468\/ogs.2016.59.1.66"},{"key":"2024052407212424367_j_crpm-2024-0006_ref_003","doi-asserted-by":"crossref","unstructured":"Perelman, AH, Johnson, RL, Clemons, RD, Finberg, HJ, Clewell, WH, Trujillo, L. Intrauterine diagnosis and treatment of fetal goitrous hypothyroidism. J Clin Endocrinol Metab 1990;71:618\u201321. https:\/\/doi.org\/10.1210\/jcem-71-3-618.","DOI":"10.1210\/jcem-71-3-618"},{"key":"2024052407212424367_j_crpm-2024-0006_ref_004","doi-asserted-by":"crossref","unstructured":"Nemescu, D, Tanasa, IA, Stoian, DL, Navolan, DB, Vinturache, AE. Conservative in utero treatment of fetal dyshormonogenetic goiter with levothyroxine, a systematic literature review. Exp Ther Med 2020;20:2434\u20138. https:\/\/doi.org\/10.3892\/etm.2020.8794.","DOI":"10.3892\/etm.2020.8794"},{"key":"2024052407212424367_j_crpm-2024-0006_ref_005","doi-asserted-by":"crossref","unstructured":"Ribault, V, Castanet, M, Bertrand, AM, Guibourdenche, J, Vuillard, E, Luton, D, et al.. Experience with intraamniotic thyroxine treatment in nonimmune fetal goitrous hypothyroidism in 12 cases. J Clin Endocrinol Metab 2009;94:3731\u20139. https:\/\/doi.org\/10.1210\/jc.2008-2681.","DOI":"10.1210\/jc.2008-2681"},{"key":"2024052407212424367_j_crpm-2024-0006_ref_006","doi-asserted-by":"crossref","unstructured":"Gaudry, P, Grange, G, Lebbar, A, Choiset, A, Girard, S, Goffinet, F, et al.. Fetal loss after amniocentesis in a series of 5,780 procedures. Fetal Diagn Ther 2008;23:217\u201321. https:\/\/doi.org\/10.1159\/000116744.","DOI":"10.1159\/000116744"},{"key":"2024052407212424367_j_crpm-2024-0006_ref_007","doi-asserted-by":"crossref","unstructured":"Vasudevan, P, Powell, C, Nicholas, AK, Scudamore, L, Greening, J, Park, SM, et al.. Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation. Endocrinol Diabetes Metab Case Rep 2017;2017. https:\/\/doi.org\/10.1530\/edm-17-0040.","DOI":"10.1530\/EDM-17-0040"},{"key":"2024052407212424367_j_crpm-2024-0006_ref_008","doi-asserted-by":"crossref","unstructured":"Katagiri, R, Asakura, K, Uechi, K, Masayasu, S, Sasaki, S. Iodine excretion in 24-hour urine collection and its dietary determinants in healthy Japanese adults. J Epidemiol 2016;26:613\u201321. https:\/\/doi.org\/10.2188\/jea.je20150245.","DOI":"10.2188\/jea.JE20150245"},{"key":"2024052407212424367_j_crpm-2024-0006_ref_009","doi-asserted-by":"crossref","unstructured":"Kourides, IA, Heath, CV, Ginsberg-Fellner, F. Measurement of thyroid-stimulating hormone in human amniotic fluid. J Clin Endocrinol Metab 1982;54:635\u20137. https:\/\/doi.org\/10.1210\/jcem-54-3-635.","DOI":"10.1210\/jcem-54-3-635"},{"key":"2024052407212424367_j_crpm-2024-0006_ref_010","doi-asserted-by":"crossref","unstructured":"Bernardes, LS, Ruano, R, Sapienza, AD, Maganha, CA, Zugaib, M. 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Successful in utero treatment of fetal goiter and hypothyroidism. N Engl J Med 1991;324:543\u20136. https:\/\/doi.org\/10.1056\/nejm199102213240807.","DOI":"10.1056\/NEJM199102213240807"},{"key":"2024052407212424367_j_crpm-2024-0006_ref_016","doi-asserted-by":"crossref","unstructured":"Kanike, N, Davis, A, Shekhawat, PS. Transient hypothyroidism in the newborn: to treat or not to treat. Transl Pediatr 2017;6:349\u201358. https:\/\/doi.org\/10.21037\/tp.2017.09.07.","DOI":"10.21037\/tp.2017.09.07"},{"key":"2024052407212424367_j_crpm-2024-0006_ref_017","doi-asserted-by":"crossref","unstructured":"Salerno, M, Militerni, R, Di Maio, SD, Bravaccio, C, Gasparini, N, Tenore, A. Intellectual outcome at 12 years of age in congenital hypothyroidism. 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