{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:23:37Z","timestamp":1790713417808,"version":"4.1.0"},"reference-count":16,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_crpm-2024-0025_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To detect fetal hyaloid artery (FHA) blood flow using Slow<jats:italic>flow<\/jats:italic>HD in the first trimester.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_crpm-2024-0025_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>During the 8-month period from February to September 2023, one-hundred and eighty-three trans-abdominal scans were performed for first-trimester screening in singleton pregnancies at 11\u201313\u00a0+\u00a06\u00a0weeks of gestation. One-hundred and fifty-two cases were excluded from the study due to inappropriate fetal positions, excessive fetal movements, and excessive distances between the fetus and probe; thus, thirty-one fetuses (20.4\u202f%) were examined, comprising 19 uni- and 12 bilateral orbits. One fetus with trisomy 21 was also evaluated at 12\u00a0weeks and 1\u00a0day. FHA was classified into two types based on the starting point angle (Straight, straightly diverged from ophthalmic artery; and Curved, crookedly diverged from ophthalmic artery) using Slow<jats:italic>flow<\/jats:italic>HD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_crpm-2024-0025_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In 19 uni- and 12 bilateral orbits in 31 fetuses, FHA could be identified in all orbits. In one orbit at 13\u00a0weeks and\u00a05\u00a0days, blood flow on the string FHA could be detected. The vasa hyaloidea propria was noted in 3 orbits, and the posterior vascular capsule was depicted in 7 orbits. The incidence of Straight-type FHA increased with advancing gestation (p&lt;0.0001). In a fetus with Trisomy 21, Straight-type FHA was noted in the left orbit, whereas FHA could not be identified in the right orbit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_crpm-2024-0025_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is the first report on the detection of FHA in the first trimester of pregnancy. Slow<jats:italic>flow<\/jats:italic>HD may be a useful diagnostic modality to evaluate human vascular development, such as FHA <jats:italic>in utero<\/jats:italic>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/crpm-2024-0025","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T16:00:13Z","timestamp":1728403213000},"source":"Crossref","is-referenced-by-count":4,"title":["Fetal hyaloid artery in first trimester of pregnancy: slow<i>flow<\/i>HD study"],"prefix":"10.1515","volume":"13","author":[{"given":"Toshiyuki","family":"Hata","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Miyake Clinic , Okayama , Japan"},{"name":"Department of Perinatology and Gynecology , Kagawa University Graduate School of Medicine , Miki , Kagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Miyake Clinic , Okayama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riko","family":"Takayoshi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Miyake Clinic , Okayama , Japan"},{"name":"Department of Perinatology and Gynecology , Kagawa University Graduate School of Medicine , Miki , Kagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunari","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Miyake Ofuku Clinic , Okayama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Miyake Clinic , Okayama , Japan"},{"name":"Department of Perinatology and Gynecology , Kagawa University Graduate School of Medicine , Miki , Kagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"2024100810110902704_j_crpm-2024-0025_ref_001","unstructured":"Bronshtein, M, Zimmer, E, Gershoni-Baruch, R, Yoffe, N, Meyer, H, Blumenfeld, Z. 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