{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:15:13Z","timestamp":1784297713909,"version":"3.55.0"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_crpm-2024-0041_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Choriocarcinoma, an aggressive form of gestational trophoblastic neoplasia, can be divided into gestational and non-gestational types, each with distinct biological activity and prognosis. We report a case of gestational choriocarcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_crpm-2024-0041_abs_002\">\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 38-year-old woman (2 Gravida, 2 Para) presented at our clinic four weeks after her second cesarean section with persistent vaginal bleeding and decreasing hemoglobin to 6.8\u202fmg\/L. In the ultrasound examination, retained placental tissue was suspected. Since conservative management with misoprostol was not effective, a curettage was performed. The histopathological result revealed a gestational choriocarcinoma invading the myometrium (CK18 positive, HPL positive, beta-hCG positive, p63 negative, PLAP positive, Ki67 (MIB-1)&gt;80\u202f%). Beta-hCG was 50,607\u202fIU\/L at the time of diagnosis. The computed tomography (CT) scan revealed bilateral pulmonary metastases. There were no metastases to the liver, lymph nodes, skeleton or brain. In accordance with FIGO recommendations [stage III, Score 8 (high risk) choriocarcinoma] a multi-drug chemotherapy after EMACO-regimen was started 9.5\u00a0weeks postpartum during 14\u00a0days for seven cycles. The patient has been in tumor remission since\u00a0then.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_crpm-2024-0041_abs_003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Choriocarcinoma is a differential diagnosis of vaginal peripartum bleeding and might likely be underdiagnosed. Risk factors like a prior hydatidiform mole or abortion, Asian, Indian American, African American or Hispanic ethnicity, advanced maternal age (&gt;40 years), blood group A, or high\/increasing beta-hCG postpartum should be taken into consideration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/crpm-2024-0041","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T19:58:56Z","timestamp":1749844736000},"source":"Crossref","is-referenced-by-count":3,"title":["Gestational choriocarcinoma FIGO stage III, score 8 (high-risk) in 38-year-old woman four weeks postpartum"],"prefix":"10.1515","volume":"14","author":[{"given":"Clara","family":"Illi","sequence":"first","affiliation":[{"name":"Department of Obstetrics , 14903 Charit\u00e9 University Hospital , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Henrich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , 14903 Charit\u00e9 University Hospital , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Hinkson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , 14903 Charit\u00e9 University Hospital , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"2025122008251823369_j_crpm-2024-0041_ref_001","doi-asserted-by":"crossref","unstructured":"Seckl, MJ, Sebire, NJ, Fisher, RA, Golfier, F, Massuger, L, Sessa, C. Gestational trophoblastic disease: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013;24:vi39\u201350. https:\/\/doi.org\/10.1093\/annonc\/mdt345.","DOI":"10.1093\/annonc\/mdt345"},{"key":"2025122008251823369_j_crpm-2024-0041_ref_002","doi-asserted-by":"crossref","unstructured":"Lurain, JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol 2010;203:531\u20139. https:\/\/doi.org\/10.1016\/j.ajog.2010.06.073.","DOI":"10.1016\/j.ajog.2010.06.073"},{"key":"2025122008251823369_j_crpm-2024-0041_ref_003","unstructured":"Mosayebi, Z, Movahedian, A, Malekzadeh, I. Infantile and maternal choriocarcinoma: a case report and review of literature. 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