{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:16:59Z","timestamp":1793254619973,"version":"4.5.0"},"reference-count":9,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_crpm-2025-0010_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Intravenous immunoglobulin (IVIG) in pregnancy has been used to treat hematologic conditions, but there is limited literature on its use in acute Parvovirus B19 infection. The purpose of this report is to highlight IVIG treatment recommendations based on low reticulocyte counts and high middle cerebral artery peak systolic velocity (MCA-PSV) values to prevent fetal hydrops, as well as identify which patients would benefit from high-dose IVIG administration in the setting of acute Parvovirus B19 infection in the second trimester.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_crpm-2025-0010_abs_002\">\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We present the treatment of acute Parvovirus B19 infection with IVIG in two affected pregnancies, as an alternative to percutaneous umbilical blood sampling (PUBS) and intrauterine transfusion (IUT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_crpm-2025-0010_abs_003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IVIG may be useful for Parvovirus B19 treatment in patients with erythropoietic suppression, in patients who decline PUBS\/IUT with elevated MCA-PSV, and in patients who have difficult access to the placental cord insertion site, unsuccessful attempt at PUBS, or relative contraindications (i.e.\u00a0significant abdominal surgery, high\u00a0BMI).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/crpm-2025-0010","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:55:11Z","timestamp":1758124511000},"source":"Crossref","is-referenced-by-count":1,"title":["Intravenous immunoglobulin (IVIG) therapy in pregnancies complicated by acute Parvovirus B19 infection in the second trimester: a case series"],"prefix":"10.1515","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-3664","authenticated-orcid":false,"given":"Rachel","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Maternal Fetal Medicine , Stony Brook University Hospital , Stony Brook , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5398-7596","authenticated-orcid":false,"given":"David","family":"Garry","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine , Stony Brook University Hospital , Stony Brook , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine , Stony Brook University Hospital , Stony Brook , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine , Stony Brook University Hospital , Stony Brook , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4027-1337","authenticated-orcid":false,"given":"Cassandra","family":"Heiselman","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine , Stony Brook University Hospital , Stony Brook , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bernasko","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine , Stony Brook University Hospital , Stony Brook , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenobia","family":"Gonsalves","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine , Stony Brook University Hospital , Stony Brook , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Stetler","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine , Stony Brook University Hospital , Stony Brook , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9687-6669","authenticated-orcid":false,"given":"Tiffany","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine , Stony Brook University Hospital , Stony Brook , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Garduno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Stony Brook University Hospital , Stony Brook , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Avila","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine , Stony Brook University Hospital , Stony Brook , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"2025122008251821769_j_crpm-2025-0010_ref_001","doi-asserted-by":"crossref","unstructured":"Selbing, A Josefsson, A Dahle, L Lindgren, RParvovirus B19 infection during pregnancy treated with high-dose intravenous gammaglobulin Lancet 1995;345:660\u20131. https:\/\/doi.org\/10.1016\/s0140-6736(95)90569-3.","DOI":"10.1016\/S0140-6736(95)90569-3"},{"key":"2025122008251821769_j_crpm-2025-0010_ref_002","doi-asserted-by":"crossref","unstructured":"Brown, KE, Young, NS. Parvoviruses and bone marrow failure. Stem Cell 1996;14:151\u201363. https:\/\/doi.org\/10.1002\/stem.140151.","DOI":"10.1002\/stem.140151"},{"key":"2025122008251821769_j_crpm-2025-0010_ref_003","doi-asserted-by":"crossref","unstructured":"Sturm, I, Watschinger, B, Klaus Gei\u00dfler, Guber, SE, Popow\u2010Kraupp, T, H\u00f6rl, WH, et al.. Chronic parvovirus B19\u00a0infection-associated pure red cell anaemia in a kidney transplant recipient. Nephrol Dial Transplant. 1996;11:1367\u201370, https:\/\/doi.org\/10.1093\/oxfordjournals.ndt.a027560.","DOI":"10.1093\/oxfordjournals.ndt.a027560"},{"key":"2025122008251821769_j_crpm-2025-0010_ref_004","doi-asserted-by":"crossref","unstructured":"Aronson, ST, Celiker, MY, Guarini, L, Agha, R. Intravenous immunoglobulin treatment of congenital parvovirus B19 induced anemia\u00a0\u2013\u00a0a case report. Matern Health Neonatol Perinatol [Internet]. 2023;9(1):10. https:\/\/doi.org\/10.1186\/s40748-023-00164-2.","DOI":"10.1186\/s40748-023-00164-2"},{"key":"2025122008251821769_j_crpm-2025-0010_ref_005","unstructured":"Parvovirus B19\u00a0\u2013\u00a0Society for Maternal-Fetal Medicine [Internet]. Smfm.org; 2017. Available from: https:\/\/www.smfm.org\/parvovirus-b19."},{"key":"2025122008251821769_j_crpm-2025-0010_ref_006","doi-asserted-by":"crossref","unstructured":"Lindblom, A, Isa, A, Norbeck, O, Wolf, S, Johansson, B, Broliden, K, et al.. Slow clearance of human parvovirus B19 viremia following acute infection. Clin Infect Dis 2005;41:1201\u20133. https:\/\/doi.org\/10.1086\/444503.","DOI":"10.1086\/444503"},{"key":"2025122008251821769_j_crpm-2025-0010_ref_007","doi-asserted-by":"crossref","unstructured":"Timo, MFCB, Oepkes, D, Eveline, KM, Walther, FJ, Kroes, ACM. Parvovirus B19 infection in pregnancy: maternal and fetal viral load measurements related to clinical parameters. Prenat Diagn 2006;27:46\u201350. https:\/\/doi.org\/10.1002\/pd.1619.","DOI":"10.1002\/pd.1619"},{"key":"2025122008251821769_j_crpm-2025-0010_ref_008","doi-asserted-by":"crossref","unstructured":"Mari, G, Norton, ME, Stone, J, Berghella, V, Sciscione, AC, Tate, D, et al.. Society for Maternal-Fetal Medicine (SMFM) Clinical Guideline #8: the fetus at risk for anemia\u2013diagnosis and management. Am J Obstet Gynecol 2015;212:697\u2013710. https:\/\/doi.org\/10.1016\/j.ajog.2015.01.059.","DOI":"10.1016\/j.ajog.2015.01.059"},{"key":"2025122008251821769_j_crpm-2025-0010_ref_009","doi-asserted-by":"crossref","unstructured":"Oepkes, D, Seaward, PG, Vandenbussche, FPHA, Windrim, R, Kingdom, J, Beyene, J, et al.. Doppler ultrasonography versus amniocentesis to predict fetal anemia. N\u00a0Engl J Med 2006;355:156\u201364. https:\/\/doi.org\/10.1056\/nejmoa052855.","DOI":"10.1056\/NEJMoa052855"}],"container-title":["Case Reports in Perinatal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/crpm-2025-0010\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/crpm-2025-0010\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T08:25:28Z","timestamp":1766219128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/crpm-2025-0010\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,7,9]]},"published-print":{"date-parts":[[2025,1,29]]}},"alternative-id":["10.1515\/crpm-2025-0010"],"URL":"https:\/\/doi.org\/10.1515\/crpm-2025-0010","relation":{},"ISSN":["2192-8959"],"issn-type":[{"value":"2192-8959","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]},"article-number":"20250010"}}