{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:07:13Z","timestamp":1790352433426,"version":"4.1.0"},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_crpm-2025-0030_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Congenital neuroblastoma is one of the most common solid tumors in the perinatal period; however, primary cranial localization with prenatal onset is extremely rare. We present a unique case of cranio-orbito-maxillary congenital neuroblastoma detected during the early second trimester, highlighting its dynamic prenatal evolution, diagnostic challenges, and postnatal clinical course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_crpm-2025-0030_abs_002\">\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 36-year-old pregnant woman was referred at 15\u00a0weeks of gestation with a suspected fetal cranial cyst. Fetal neurosonography revealed a unilocular, avascular cystic lesion near the midline of the left cerebral hemisphere, initially suggestive of an arachnoid cyst. Serial follow-up demonstrated progressive morphological transformation, with the lesion acquiring heterogeneous solid components and extending toward the retroorbital and maxillary regions. Fetal magnetic resonance imaging confirmed a large solid-cystic retroorbital mass with orbital displacement and extension into adjacent structures. The pregnancy was complicated by polyhydramnios in the third trimester. A female infant was delivered at 36\u00a0weeks of gestation and exhibited marked postnatal proptosis. Histopathological and immunohistochemical evaluation of a tru-cut biopsy established the diagnosis of grade 4 neuroblastoma. Despite multidisciplinary management and multimodal chemotherapy, the disease progressed with pulmonary metastases, and the infant died at 15\u00a0months of age during palliative\u00a0care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_crpm-2025-0030_abs_003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case illustrates an exceptionally rare presentation of congenital neuroblastoma originating as a prenatal cranial cystic lesion with progressive cranio-orbito-maxillary involvement. Neuroblastoma should be considered in the differential diagnosis of atypical fetal cranial or orbital masses. Careful prenatal surveillance, advanced imaging, and multidisciplinary perinatal planning are crucial for optimal postnatal management and family counselling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/crpm-2025-0030","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:08:49Z","timestamp":1790345329000},"source":"Crossref","is-referenced-by-count":0,"title":["Prenatal diagnosis of cranio-orbito-maxillary neuroblastoma: a case report"],"prefix":"10.1515","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8332-7273","authenticated-orcid":false,"given":"Busra Berfin","family":"Polat","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Obstetrics and Gynecology , Inonu University , Malatya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-6691","authenticated-orcid":false,"given":"Rauf","family":"Melekoglu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Obstetrics and Gynecology , Inonu University , Malatya , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-0901","authenticated-orcid":false,"given":"Servet","family":"Guresci","sequence":"additional","affiliation":[{"name":"Ankara Bilkent City Hospital, Department of Pathology , Ankara , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"2026092515335297946_j_crpm-2025-0030_ref_001","doi-asserted-by":"crossref","unstructured":"Hero, B, Simon, T, Spitz, R, Ernestus, K, Gnekow, AK, Scheel-Walter, HG, et al.. Localized infant neuroblastomas often show spontaneous regression: results of the prospective trials NB95-S and NB97. J\u00a0Clin Oncol 2008;26:1504\u201310. https:\/\/doi.org\/10.1200\/jco.2007.12.3349.","DOI":"10.1200\/JCO.2007.12.3349"},{"key":"2026092515335297946_j_crpm-2025-0030_ref_002","doi-asserted-by":"crossref","unstructured":"Brodeur, GM. Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 2003;3:203\u201316. https:\/\/doi.org\/10.1038\/nrc1014.","DOI":"10.1038\/nrc1014"},{"key":"2026092515335297946_j_crpm-2025-0030_ref_003","doi-asserted-by":"crossref","unstructured":"Shimada, H, Ambros, IM, Dehner, LP, Hata, J, Joshi, VV, Roald, B, et al.. The international neuroblastoma pathology classification (the Shimada system). 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