{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:24:05Z","timestamp":1780514645911,"version":"3.54.1"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_crpm-2026-0002_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Premature constriction of the fetal ductus arteriosus is a clinically relevant cause of fetal cardiac compromise. Maternal exposure to prostaglandin-inhibiting analgesics is a recognized trigger. We describe two pregnancies complicated by fetal ductus arteriosus constriction temporally associated with maternal analgesic\u00a0use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_crpm-2026-0002_abs_002\">\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>In the first case, ductal constriction occurred after a seven-day course of indomethacin initiated at 28\u00a0weeks\u2019 gestation for polyhydramnios. Although initial improvement followed drug discontinuation, recurrent constriction with right ventricular dilation, severe tricuspid regurgitation, ductus venosus A-wave reversal, and a non-reactive fetal heart rate tracing indicated progressive hemodynamic compromise, prompting preterm delivery at 31+6\u00a0weeks. Postnatal echocardiography showed normalization of right ventricular function. In the second case, ductal constriction with right ventricular dilation and tricuspid regurgitation was detected at 38+5\u00a0weeks after frequent third-trimester use of a paracetamol-containing analgesic. Delivery at 39\u00a0weeks was performed primarily for prior uterine surgery, and postnatal evaluation confirmed normal pulmonary pressures and right ventricular function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_crpm-2026-0002_abs_003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Maternal exposure to prostaglandin-inhibiting analgesics should be considered in cases of fetal ductus arteriosus constriction. Careful medication history and targeted fetal echocardiography are essential for timely diagnosis and appropriate perinatal management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/crpm-2026-0002","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:01:00Z","timestamp":1778644860000},"source":"Crossref","is-referenced-by-count":1,"title":["Fetal ductus arteriosus constriction following maternal analgesic exposure"],"prefix":"10.1515","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5749-4556","authenticated-orcid":false,"given":"Ayberk","family":"\u00c7ak\u0131r","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , Ac\u0131badem Mehmet Ali Ayd\u0131nlar University Atakent Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7833-2422","authenticated-orcid":false,"given":"Edis","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Ac\u0131badem Mehmet Ali Ayd\u0131nlar University Atakent Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1715-6208","authenticated-orcid":false,"given":"Deniz","family":"Gedik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Ac\u0131badem Mehmet Ali Ayd\u0131nlar University Atakent Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3003-2133","authenticated-orcid":false,"given":"Nefise Beng\u00fc","family":"Akg\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Ac\u0131badem Mehmet Ali Ayd\u0131nlar University Atakent Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ayta\u00e7","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Ac\u0131badem Mehmet Ali Ayd\u0131nlar University Atakent Hospital , Istanbul , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"2026051304005349788_j_crpm-2026-0002_ref_001","doi-asserted-by":"crossref","unstructured":"Gruzdev, A, Nguyen, M, Kovarova, M, Koller, BH. 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