{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:48:00Z","timestamp":1792172880986,"version":"4.4.0"},"reference-count":8,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_crpm-2026-0014_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Ependymomas are rare glial tumors arising from ependymal cells. Most fetal ependymomas reported in the literature are identified in the third trimester. This report describes prenatal detection of an occipital encephalocele at 14\u00a0weeks\u2019 gestation with subsequent post-termination histopathological identification of ependymoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_crpm-2026-0014_abs_002\">\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A woman in her 20s (gravida 2, para 0) underwent routine ultrasonography at 14\u00a0weeks\u2019 gestation at a tertiary care hospital in India. Imaging showed a large occipital encephalocele with herniated disorganized brain parenchyma and associated fetal anomalies; no antenatal tumor diagnosis was made. After counseling regarding the severe cranial malformation, guarded prognosis, and management options, the parents elected medical termination of pregnancy. The fetus weighed 40\u202fg. Histopathological examination showed monomorphic cells forming perivascular pseudorosettes and ependymal canal-like structures. Glial fibrillary acidic protein highlighted the perivascular processes; epithelial membrane antigen and S-100 were negative. The histomorphological features supported a histology-based diagnosis of ependymoma, CNS WHO grade 2. Molecular studies were not performed; therefore, molecular subgrouping was unavailable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_crpm-2026-0014_abs_003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>At 14\u00a0weeks\u2019 gestation, ultrasonography identified an occipital encephalocele, whereas ependymoma was identified only by post-termination histopathological examination. This case emphasizes early anatomical assessment, balanced parental counseling, and clinicopathological correlation while acknowledging uncertainty regarding the relationship between the encephalocele and the neoplasm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/crpm-2026-0014","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:56:04Z","timestamp":1792169764000},"source":"Crossref","is-referenced-by-count":0,"title":["Ependymoma in a 14-week fetus with occipital encephalocele: a case report"],"prefix":"10.1515","volume":"15","author":[{"given":"Mamatha","family":"K","sequence":"first","affiliation":[{"name":"Department of Pathology , BLDE (Deemed to be University), Shri B. M. Patil Medical College Hospital and Research Centre , Vijayapura , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshi","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pathology , FH Medical College , Agra , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailaja R.","family":"Bidri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , BLDE (Deemed to be University), Shri B. M. Patil Medical College Hospital and Research Centre , Vijayapura , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Susan","family":"A J","sequence":"additional","affiliation":[{"name":"Department of Pathology , BLDE (Deemed to be University), Shri B. M. Patil Medical College Hospital and Research Centre , Vijayapura , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4839-9152","authenticated-orcid":false,"given":"Sayandeep K.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pathology , BLDE (Deemed to be University), Shri B. M. Patil Medical College Hospital and Research Centre , Vijayapura , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"2026101616555799885_j_crpm-2026-0014_ref_001","doi-asserted-by":"crossref","unstructured":"Louis, DN, Perry, A, Wesseling, P, Brat, DJ, Cree, IA, Figarella-Branger, D, et al.. The 2021 WHO classification of tumors of the central nervous system: a summary. 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Prenat Diagn 2020;40:1203\u201319. https:\/\/doi.org\/10.1002\/pd.5722.","DOI":"10.1002\/pd.5722"},{"key":"2026101616555799885_j_crpm-2026-0014_ref_005","doi-asserted-by":"crossref","unstructured":"Engels, AC, Joyeux, L, Brantner, C, De Keersmaecker, B, De Catte, L, Baud, D, et al.. Sonographic detection of central nervous system defects in the first trimester of pregnancy. Prenat Diagn 2016;36:266\u201373. https:\/\/doi.org\/10.1002\/pd.4770.","DOI":"10.1002\/pd.4770"},{"key":"2026101616555799885_j_crpm-2026-0014_ref_006","doi-asserted-by":"crossref","unstructured":"Edwards, L, Hui, L. First and second trimester screening for fetal structural anomalies. Semin Fetal Neonatal Med 2018;23:102\u201311. https:\/\/doi.org\/10.1016\/j.siny.2017.11.005.","DOI":"10.1016\/j.siny.2017.11.005"},{"key":"2026101616555799885_j_crpm-2026-0014_ref_007","doi-asserted-by":"crossref","unstructured":"Gagnier, JJ, Kienle, G, Altman, DG, Moher, D, Sox, H, Riley, D, et al.. The CARE guidelines: consensus-based clinical case reporting guideline development. Glob Adv Health Med 2013;2:38\u201343.","DOI":"10.7453\/gahmj.2013.008"},{"key":"2026101616555799885_j_crpm-2026-0014_ref_008","doi-asserted-by":"crossref","unstructured":"Foss-Skiftesvik, J, Stoltze, UK, van Overeem Hansen, T, Ahlborn, LB, S\u00f8rensen, E, Ostrowski, SR, et al.. Redefining germline predisposition in\u00a0children with molecularly characterized ependymoma: a population-based 20-year cohort. 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