{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:52:55Z","timestamp":1767181975978,"version":"build-2238731810"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dmpt-2020-0147_abs_001_w2aab3b7c15b1b6b1aab1c15b1Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Concurrent use of herbs with drugs have become a major healthcare problem. Herb-drug interactions could lead to therapeutic failure or toxicity. Hence, this study seeks to evaluate the impact of combining\n                      <jats:italic>Curcuma longa<\/jats:italic>\n                      rhizome (CL) with selected anxiolytic and hypnotic drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2020-0147_abs_002_w2aab3b7c15b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CL (100, 200 or 400\u00a0mg\/kg, p.o.) was administered to mice 1\u00a0h before subjecting the animals to elevated plus maze (EPM), hole board test (HBT), open field test (OFT) and rotarod test for anxiolytic-like effect as well as hexobarbitone-induced sleeping time (HIST) for hypnotic activity. The involvement of GABAergic and nitrergic systems in CL-induced anxiolytic and hypnotic actions were also evaluated. The effect of concurrent use of CL with midazolam, imipramine, nifedipine, propranolol and carbamazepine were evaluated in anxiolytic-hypnosis models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2020-0147_abs_003_w2aab3b7c15b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The peak anxiolytic-like effect of CL was obtained at 400\u00a0mg\/kg in the EPM and hole-board test without affecting muscle coordination in the rotarod test while the peak hypnosis-potentiation was observed at 100\u00a0mg\/kg. CL-induced anxiolytic-hypnotic-like effects were reversed by the pretreatment of mice with flumazenil or N\n                      <jats:sup>G<\/jats:sup>\n                      -nitro-\n                      <jats:sc>l<\/jats:sc>\n                      -arginine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2020-0147_abs_004_w2aab3b7c15b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Curcuma longa<\/jats:italic>\n                      possesses anxiolytic and hypnotic effects through its interaction with GABAergic and nitrergic systems. Conversely, co-administration of\n                      <jats:italic>C.\u00a0longa<\/jats:italic>\n                      with midazolam potentiate barbiturate-induced hypnosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dmpt-2020-0147","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T09:57:02Z","timestamp":1657879022000},"page":"135-143","source":"Crossref","is-referenced-by-count":1,"title":["Involvement of GABAergic and nitrergic systems in the anxiolytic and hypnotic effects of\n                    <i>Curcuma longa<\/i>\n                    : its interaction with anxiolytic-hypnotics"],"prefix":"10.1515","volume":"36","author":[{"given":"Ismail O.","family":"Ishola","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology , Faculty of Basic Medical Sciences, College of Medicine, University of Lagos , Lagos , Lagos State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Folashade O.","family":"Katola","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology , Faculty of Basic Medical Sciences, College of Medicine, University of Lagos , Lagos , Lagos State , Nigeria"},{"name":"Department of Pharmacy , School of Applied Sciences, University of Huddersfield , Huddersfield , HD1 3DH , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olufunmilayo O.","family":"Adeyemi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology , Faculty of Basic Medical Sciences, College of Medicine, University of Lagos , Lagos , Lagos State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"2022071513543080288_j_dmpt-2020-0147_ref_001_w2aab3b7c15b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Meng, Q, Liu, K. 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