{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:37:26Z","timestamp":1765525046569,"version":"3.48.0"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The aqueous ethanolic extract from leaves of the marine plant\n                    <jats:italic>Thalassia testudinum<\/jats:italic>\n                    has shown antioxidant, cytoprotective, and neuroprotective properties. The chemical composition of this extract, rich in polyphenols, could interfere with active transport of drugs out of the cell and circumvent the phenomenon of multidrug resistance (MDR). The extract can act as an MDR modulator through its interaction with efflux transporters. The ABCG2\/BCRP has been shown to confer MDR acting in tumor cells.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    To evaluate the interaction of ABCG2\/BCRP with the extract, studies in cells overexpressing human BCRP transporter and its murine ortholog Bcrp1 were performed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results and conclusions:<\/jats:bold>\n                    <jats:italic>T. testudinum<\/jats:italic>\n                    extract could be included as MDR modulator, as interaction with ABCG2\/BCRP has been shown through flow cytometry and MTT assays. The cells overexpressing ABCG2\/BCRP in the presence of the extract (25\u2013150 \u03bcg\/mL) decreased the survival rates of the anti-tumoral mitoxantrone. Our results support its inclusion as a possible MDR modulator against tumor cells that overexpress ABCG2\/BCRP.\n                  <\/jats:p>","DOI":"10.1515\/dmpt-2015-0013","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T16:13:41Z","timestamp":1444234421000},"page":"251-256","source":"Crossref","is-referenced-by-count":1,"title":["ABCG2\/BCRP interaction with the sea grass\n                    <i>Thalassia testudinum<\/i>"],"prefix":"10.1515","volume":"30","author":[{"given":"Ver\u00f3nica","family":"Miguel","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas-Fisiolog\u00eda, Facultad de Veterinaria, Universidad de Le\u00f3n, Campus de Vegazana s\/n, 24071 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon A.","family":"Otero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borja","family":"Barrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idania","family":"Rodeiro","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Centro de Bioproductos Marinos (CEBIMAR), Loma 37, Nuevo Vedado, La Habana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio G.","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gracia","family":"Merino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana I.","family":"\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2015,10,7]]},"reference":[{"key":"2025121207003121558_j_dmpt-2015-0013_ref_001_w2aab2b8c14b1b7b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Li Y, Revalde JL, Reid G, Paxton JW. 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