{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:30:15Z","timestamp":1765546215503,"version":"3.41.0"},"reference-count":68,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Therapeutic drug monitoring is essential for both phenytoin and phenobarbital therapy given their narrow therapeutic indexes. Nevertheless, the measurement of either phenytoin or phenobarbital concentrations might not be available in some rural hospitals. Information assisting individualized phenytoin and phenobarbital combination therapy is important. This study\u2019s objective was to determine the relationship between the maximum rate of metabolism of phenytoin (V<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Data on phenytoin and phenobarbital concentrations of 19 epileptic patients concurrently receiving both drugs were obtained from medical records. Phenytoin and phenobarbital pharmacokinetic parameters were studied at steady-state conditions. The relationship between the elimination parameters of both drugs was determined using simple linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A high correlation coefficient between V<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Regression equations were established for estimating V<\/jats:p><\/jats:sec>","DOI":"10.1515\/dmpt-2017-0017","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T10:01:11Z","timestamp":1504605671000},"source":"Crossref","is-referenced-by-count":2,"title":["Preliminary study of the association between the elimination parameters of phenytoin and phenobarbital"],"prefix":"10.1515","volume":"32","author":[{"given":"Janthima","family":"Methaneethorn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duangchit","family":"Panomvana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaveechai","family":"Vachirayonstien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref691","first-page":"242","article-title":"Induction of CYP2C genes in human hepatocytes in primary culture","volume":"29","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1093\/clinchem\/27.9.1575","article-title":"Fluorescence polarization immunoassay. 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