{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:00:11Z","timestamp":1783346411225,"version":"3.54.6"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"j_dmpt-2019-0003_s_999\">\n<jats:title id=\"d2980143e15930\">Background<\/jats:title>\n<jats:p>The aim of the current study was to evaluate the efficacy of D-penicillamine in the treatment of lead poisoning <jats:italic>mainly<\/jats:italic> in the outpatient setting.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"j_dmpt-2019-0003_s_998\">\n<jats:title id=\"d2980143e15942\">Methods<\/jats:title>\n<jats:p>In a case series study performed during the recent epidemic of lead poisoning in Iran, lead-poisoned patients referring to our outpatient clinic were treated with 250-mg D-penicillamine capsules administered every 6 h for 5 or 10 days based on availability of the medication. They were recommended to re-check blood lead level (BLL) 4 weeks after cessation of the treatment and refer to our clinic again.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"j_dmpt-2019-0003_s_997\">\n<jats:title id=\"d2980143e15951\">Results<\/jats:title>\n<jats:p>In 63 patients with lead poisoning but without signs and symptoms of lead encephalopathy, median BLL was 106 [84, 131] \u03bcg\/dL on presentation, which declined to a mean of 52.6 \u00b1 28.8 \u03bcg\/dL after a median treatment period of 7 [5, 10] days (p &lt; 0.001). There was no statistically significant difference between the 5- and 10-day treatment protocols regarding complications and recovery. Treatment had resulted in a median decrease of 54 \u03bcg\/dL [33, 90] (range: \u221220 to 231 \u03bcg\/dL) in the patients\u2019 BLLs (33.9% declined in BLL measurements; range: \u221229.69% to 99.06%).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"j_dmpt-2019-0003_s_996\">\n<jats:title id=\"d2980143e15960\">Conclusions<\/jats:title>\n<jats:p>D-penicillamine may be an acceptable substitute treatment in adult lead poisoning. Although our sample size was limited, we could not detect any serious adverse effects in our cases showing that D-penicillamine resulted in acceptable recovery rates. This may be helpful especially in epidemics with limitations in antidote access.<\/jats:p>\n<\/jats:sec>","DOI":"10.1515\/dmpt-2019-0003","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T09:03:41Z","timestamp":1560330221000},"source":"Crossref","is-referenced-by-count":7,"title":["Treatment of adult lead poisoning with D-penicillamine"],"prefix":"10.1515","volume":"34","author":[{"given":"Maryam","family":"Paeezi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Zamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Hassanian-Moghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahin","family":"Shadnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naghmeh","family":"Zamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Chaleshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Ali","family":"Mafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref131","year":"2010","journal-title":"Oral chelation therapy for patients with lead poisoning. 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the epidemiologic trend between 2006 and 2011","volume":"17","year":"2014","journal-title":"Arch Iran Med"},{"key":"ref31","first-page":"184","article-title":"Brief overview of the status of drug abuse in Iran","volume":"5","year":"2002","journal-title":"Arch Iran Med"},{"key":"ref81","first-page":"208","article-title":"Opium addiction and lead poisoning","volume":"16","year":"2011","journal-title":"J Subst Abuse"},{"key":"ref191","first-page":"483","article-title":"[Lead poisoning due to drug addiction: a new source of poisoning with clinical interest and important epidemiological consequences]","volume":"6","year":"1989","journal-title":"An Med Interna"},{"key":"ref201","first-page":"184","article-title":"Brief overview of the status of drug abuse in Iran","volume":"5","year":"2002","journal-title":"Arch Iran Med"},{"key":"ref231","first-page":"72","article-title":"Abdominal pain due to lead-contaminated opium: a new source of inorganic lead poisoning in Iran","volume":"9","year":"2006","journal-title":"Arch Iran Med"},{"key":"ref291","first-page":"8","article-title":"Adverse effects of reduced D-penicillamine in children with mild to moderate lead poisoning","volume":"34","year":"2000","journal-title":"Ann Pharmacother"},{"key":"ref221","first-page":"106","article-title":"Lead serum levels in opium-dependent individuals","volume":"1","year":"2009","journal-title":"Addict Health"},{"key":"ref301","year":"2010","journal-title":"Oral chelation therapy for patients with lead poisoning. 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