{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:43:44Z","timestamp":1790545424496,"version":"4.1.0"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"3","funder":[{"DOI":"10.13039\/501100009530","name":"Jawaharlal Institute of Postgraduate Medical Education and Research","doi-asserted-by":"crossref","award":["JIP\/Res\/Intra-Faculty\/PHS1\/01\/2017-18"],"award-info":[{"award-number":["JIP\/Res\/Intra-Faculty\/PHS1\/01\/2017-18"]}],"id":[{"id":"10.13039\/501100009530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dmpt-2020-0178_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To evaluate the association of\n                      <jats:italic>VDR<\/jats:italic>\n                      polymorphisms (\n                      <jats:italic>FokI<\/jats:italic>\n                      ,\n                      <jats:italic>TaqI<\/jats:italic>\n                      and\n                      <jats:italic>ApaI<\/jats:italic>\n                      ) with vitamin D levels and glycemic status in type 2 diabetes patients from Southern India.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2020-0178_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this observational study, genotype frequencies and vitamin D levels of 200 cases (type 2 diabetes patients) were compared with 300 controls (unrelated anonymised stored samples of healthy volunteers) from south India. Serum 25 (OH) D levels were measured by immunoassay technique, glycated hemoglobin (HbA\n                      <jats:sub>1c<\/jats:sub>\n                      ) was measured using HPLC and genotyping of VDR polymorphisms were carried out using Real time Polymerase Chain Reaction (RT PCR).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2020-0178_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      About 69.2% of type 2 diabetes patients were found to have vitamin D deficiency.\n                      <jats:italic>FokI<\/jats:italic>\n                      polymorphism showed variations in serum 25 (OH) D levels, with AA and AG genotypes having significantly lower serum 25 (OH) D levels as compared to GG [13.24 (8.4) ng\/ml, 15.02 (7.07) ng\/ml and 20.67 (13.64) ng\/ml respectively]. There was no difference in HbA\n                      <jats:sub>1c<\/jats:sub>\n                      levels with respect to the vitamin D levels and VDR polymorphisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2020-0178_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      AA and AG genotypes of\n                      <jats:italic>FokI<\/jats:italic>\n                      polymorphisms are associated with low serum 25 (OH) D levels. However there was no association between VDR polymorphisms and glycemic status in south Indian type 2 diabetes patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dmpt-2020-0178","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T17:19:41Z","timestamp":1616087981000},"page":"183-187","source":"Crossref","is-referenced-by-count":8,"title":["Association of genetic polymorphisms in vitamin D receptor (\n                    <i>ApaI<\/i>\n                    ,\n                    <i>TaqI<\/i>\n                    and\n                    <i>FokI<\/i>\n                    ) with vitamin D and glycemic status in type 2 diabetes patients from Southern India"],"prefix":"10.1515","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-7821","authenticated-orcid":false,"given":"Sandhiya","family":"Selvarajan","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology , JIPMER , Puducherry , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akila","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology , JIPMER , Puducherry , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepanjali","family":"Surendran","sequence":"additional","affiliation":[{"name":"Department of Medicine , JIPMER , Puducherry , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanthi","family":"Mathaiyan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , JIPMER , Puducherry , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadishkumar","family":"Kamalanathan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology , JIPMER , Puducherry , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"2025121207024560407_j_dmpt-2020-0178_ref_001","doi-asserted-by":"crossref","unstructured":"Sacks, DB, McDonald, JM. 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