{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:01:17Z","timestamp":1778742077941,"version":"3.51.4"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"2","funder":[{"name":"University of Lagos Central Research Grant Committee","award":["CRC\/2017\/06"],"award-info":[{"award-number":["CRC\/2017\/06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dmpt-2021-0145_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study investigates the influence of\n                      <jats:italic>Cnestis ferruginea<\/jats:italic>\n                      (CF) on kainic acid (KA)-induced immediate early genes (IEGs) associated with hippocampal sclerosis in temporal lobe epilepsy (TLE) in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2021-0145_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Animals were randomly divided into preventive treatment; vehicle (10\u00a0mL\/kg, p.o.) or CF (400\u00a0mg\/kg, p.o.) for three consecutive days before KA (5\u00a0mg\/kg, i.p.) on days 4 and 5. In the reversal model, KA (5\u00a0mg\/kg, i.p.) was administered on days 1 and 2 before CF (400\u00a0mg\/kg) administration on days 3\u20135. Animals were euthanized on day 5, 6\u00a0h after KA exposure in preventive model and 1\u00a0h after CF administration in reversal model to estimate markers of IEGs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2021-0145_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>KA upregulated the expression of c-Fos protein by 3.32-, 9.45-, 8.13-, and 8.66-fold in the hippocampal CA1, CA2, CA3, and DG regions, respectively. Also, KA elevated inducible nitric oxide synthase protein expression by 10.9-, 10.6-, 9.78-, and 9.51-fold. Besides, mRNA expression of brain-derived neurotrophic factors and heat shock protein was increased by 2.38- and 1.39-fold, respectively, after exposure to KA which were attenuated by CF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2021-0145_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CF attenuated KA-induced IEGs and could be used as an adjunct in TLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dmpt-2021-0145","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T01:23:53Z","timestamp":1639013033000},"page":"191-200","source":"Crossref","is-referenced-by-count":1,"title":["<i>Cnestis ferruginea<\/i>\n                    Vahl ex DC (Connaraceae) downregulates expression of immediate early genes in kainic acid-induced temporal lobe epilepsy in mice"],"prefix":"10.1515","volume":"37","author":[{"given":"Emmanuel S.","family":"Ojo","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology , Faculty of Basic Medical Sciences, College of Medicine, University of Lagos , Lagos , Lagos State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail O.","family":"Ishola","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology , Faculty of Basic Medical Sciences, College of Medicine, University of Lagos , Lagos , Lagos State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olasunmbo","family":"Afolayan","sequence":"additional","affiliation":[{"name":"Department of Anatomy , Faculty of Basic Medical Sciences, College of Medicine, University of Lagos , Lagos , Lagos State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayorinde B.","family":"James","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics , Neuropharmacology Unit, College of Medicine, University of Ibadan , Ibadan , Oyo State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benneth","family":"Ben-Azu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics , Faculty of Basic Medical Sciences , Delta State University , Abraka , Delta State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olufunmilayo O.","family":"Adeyemi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology , Faculty of Basic Medical Sciences, College of Medicine, University of Lagos , Lagos , Lagos State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"2025121207074427066_j_dmpt-2021-0145_ref_001","doi-asserted-by":"crossref","unstructured":"Pitk\u00e4nen, A, Sutula, TP. 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