{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:35:12Z","timestamp":1791347712555,"version":"4.3.1"},"reference-count":49,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dmpt-2021-0166_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Ethno-botanical surveys uncovered the use of\n                      <jats:italic>Datura stramonium<\/jats:italic>\n                      in the management of mental health abnormalities. Antidepressant- and anxiolytic-like activities of hydroethanol leaf extract of\n                      <jats:italic>D.\u00a0stramonium<\/jats:italic>\n                      (HLDS) in mice and its possible mechanism of action were investigated in this study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2021-0166_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The hole-board test (HBT), open field test (OFT), elevated plus maze test (EPMT), and social interaction test (SIT) were used to investigate the anxiolytic-like activity while forced swim test (FST) and tail suspension test (TST) were employed for the antidepressant effect. Mice were pre-treated orally with purified water (10\u00a0mL\/kg), bromazepam (1\u00a0mg\/kg), fluoxetine (20\u00a0mg\/kg) and\n                      <jats:italic>D.\u00a0stramonium<\/jats:italic>\n                      (25, 50, 100 and 200\u00a0mg\/kg). One hour post-treatment, mice were subjected to the various tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2021-0166_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In HBT,\n                      <jats:italic>D.\u00a0stramonium<\/jats:italic>\n                      increased the head dips and sectional crossings turnover.\n                      <jats:italic>D.\u00a0stramonium<\/jats:italic>\n                      increased the number of square crossed and rearings\/assisted rearings in OFT.\n                      <jats:italic>DS<\/jats:italic>\n                      increased the time spent in open arms of EPM. In SIT,\n                      <jats:italic>D.\u00a0stramonium<\/jats:italic>\n                      increased the frequency\/duration of interactions. In FST and TST,\n                      <jats:italic>D.\u00a0stramonium<\/jats:italic>\n                      decreased the duration of immobility which were reversed by doxazosin (\u03b1\n                      <jats:sub>1<\/jats:sub>\n                      adrenoceptor antagonist) and ondasentron (5-HT\n                      <jats:sub>3<\/jats:sub>\n                      receptor antagonist).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2021-0166_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HLDS has anxiolytic- and antidepressant-like activities through modulation of serotoninergic and adrenergic neurotransmissions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dmpt-2021-0166","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T03:05:05Z","timestamp":1645844705000},"page":"305-314","source":"Crossref","is-referenced-by-count":5,"title":["<i>Datura stramonium<\/i>\n                    abrogates depression- and anxiety-like disorders in mice: possible involvement of monoaminergic pathways in its antidepressant activity"],"prefix":"10.1515","volume":"37","author":[{"given":"Murtala A.","family":"Akanji","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Basic Medical Sciences, Obafemi Awolowo College of Health Sciences , OlabisiOnabanjo University, Sagamu Campus , Ogun State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyinloye O.","family":"Elijah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Basic Medical Sciences, Obafemi Awolowo College of Health Sciences , OlabisiOnabanjo University, Sagamu Campus , Ogun State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alabi A.","family":"Oyedolapo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Basic Medical Sciences, Obafemi Awolowo College of Health Sciences , OlabisiOnabanjo University, Sagamu Campus , Ogun State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aderionla A.","family":"Aderonke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Basic Medical Sciences, Obafemi Awolowo College of Health Sciences , OlabisiOnabanjo University, Sagamu Campus , Ogun State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ogunjimi L.","family":"Opeoluwa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Basic Medical Sciences, Obafemi Awolowo College of Health Sciences , OlabisiOnabanjo University, Sagamu Campus , Ogun State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adesina A.","family":"Omoloye","sequence":"additional","affiliation":[{"name":"Faculty of Health , Canadian Imperial College , Alberta , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farouk A.","family":"Oladoja","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Basic Medical Sciences, Obafemi Awolowo College of Health Sciences , OlabisiOnabanjo University, Sagamu Campus , Ogun State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shonde O.","family":"Olatundun","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology , Gateway Polytechnic , Ogun state , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osipitan L.","family":"Edatomolaosi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Basic Medical Sciences, Obafemi Awolowo College of Health Sciences , OlabisiOnabanjo University, Sagamu Campus , Ogun State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"2025121207241452315_j_dmpt-2021-0166_ref_001","doi-asserted-by":"crossref","unstructured":"Rehm, J, Shield, KD. 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