{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:40:18Z","timestamp":1765525218041,"version":"3.48.0"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"4","funder":[{"DOI":"10.13039\/501100005712","name":"The University of Jordan","doi-asserted-by":"crossref","award":["Unassigned"],"award-info":[{"award-number":["Unassigned"]}],"id":[{"id":"10.13039\/501100005712","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dmpt-2021-0177_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Atorvastatin is commonly used medication to achieve low levels of low-density lipoproteins (LDL). Cholesteryl ester transfer protein (\n                      <jats:italic>CETP<\/jats:italic>\n                      ) and LDL receptor (\n                      <jats:italic>LDLR<\/jats:italic>\n                      ) genetic variants can affect the cholesterol transport and hence may affect on atorvastatin response. This study aimed to investigate the influence of\u00a0LDLR\n                      <jats:italic>AvaII<\/jats:italic>\n                      ,\n                      <jats:italic>CETP TaqIb,<\/jats:italic>\n                      and\n                      <jats:italic>Rs1532624<\/jats:italic>\n                      on the efficacy of 20\u00a0mg atorvastatin among Jordanian hyperlipidemic patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2021-0177_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and 50 blood samples were collected from hyperlipidemic patients in the University of Jordan Hospital. Polymerase chain reaction-restriction fragment length polymorphism was used for genotyping of\n                      <jats:italic>LDLR AvaII<\/jats:italic>\n                      and\n                      <jats:italic>CETP TaqIb<\/jats:italic>\n                      genetic variants. The genotyping of\n                      <jats:italic>CETP Rs1532624<\/jats:italic>\n                      variant was done by Sanger DNA-Sequencing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2021-0177_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LDLR\n                      <jats:italic>AvaII<\/jats:italic>\n                      and\n                      <jats:italic>CETP TaqIb<\/jats:italic>\n                      and\n                      <jats:italic>Rs1532624<\/jats:italic>\n                      variants showed a significant (p value\u00a0&lt;\u00a00.05) association with the baseline of the LDL at the time of diagnoses. On the other hand, none of the tested genetic variants showed a significant (p value&gt;0.05) association with LDL reduction after atorvastatin therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2021-0177_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Results demonstrated a significant association between the\n                      <jats:italic>LDLR AvaII<\/jats:italic>\n                      and\n                      <jats:italic>CETP TaqIb,<\/jats:italic>\n                      and\n                      <jats:italic>Rs1532624<\/jats:italic>\n                      genetic variants with the LDL baseline level. However, the atorvastatin therapy among hyperlipidemic patients of Jordanian origin was not affected by any of the tested variants.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dmpt-2021-0177","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T12:35:10Z","timestamp":1650544510000},"page":"369-374","source":"Crossref","is-referenced-by-count":1,"title":["No association between LDL receptor and\n                    <i>CETP<\/i>\n                    genetic variants and atorvastatin response in Jordanian hyperlipidemic patients"],"prefix":"10.1515","volume":"37","author":[{"given":"Malek","family":"Zihlif","sequence":"first","affiliation":[{"name":"Department of Pharmacology , School of Medicine, The University of Jordan , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhad","family":"Otoum","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , School of Medicine, The University of Jordan , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Al Shhab","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , School of Medicine, The University of Jordan , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaid","family":"Almadani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , School of Medicine, The University of Jordan , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monther","family":"Momani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , School of Medicine, The University of Jordan , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussam","family":"Alhawari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , School of Medicine, The University of Jordan , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Esraa jibrini","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , School of Medicine, The University of Jordan , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazun","family":"Jarrar","sequence":"additional","affiliation":[{"name":"Deprtmant of Pharmacy , College of Pharmacy, Al-Zaytoonah University of Jordan , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamzeh","family":"Al-ameer","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology , American University of Madaba , Madaba , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer","family":"Imraish","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences , School of Science, The University of Jordan , Amman , Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"2025121207013210541_j_dmpt-2021-0177_ref_001","doi-asserted-by":"crossref","unstructured":"Maitland-van der Zee, AH, Klungel, OH, Stricker, BH, Monique Verschuren, WM, Kastelein, JJ, Leufkens, HG, et al.. 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