{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:08:02Z","timestamp":1785416882377,"version":"3.56.0"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dmpt-2021-0195_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Chronic atopic dermatitis (AD) is an inflammatory skin condition marked by intense pruritus, dry skin, and severe impact on the life quality of the patients. Conventionally, it is managed by using emollients, calcineurin inhibitors, and topical corticosteroids. In Unani medicine, eminent scholars advocated many drug formulations including topical Marham-e-Akbar for effective healing of AD but scientific evidence is scarce. Hence, this study was designed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2021-0195_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a single-arm clinical trial conducted on 30 participants aged 18\u201365 years suffering from chronic AD after obtaining written informed consent. The trial intervention was Marham-e-Akbar consisting of\n                      <jats:italic>Murd\u0101r Sang<\/jats:italic>\n                      (\n                      <jats:italic>Plumbi oxidum)<\/jats:italic>\n                      ;\n                      <jats:italic>Sind\u016br<\/jats:italic>\n                      (red lead); olive oil (\n                      <jats:italic>Olea europaea<\/jats:italic>\n                      oil);\n                      <jats:italic>Kath<\/jats:italic>\n                      (\n                      <jats:italic>Acacia catechu<\/jats:italic>\n                      extract);\n                      <jats:italic>Safeda K\u0101shgari<\/jats:italic>\n                      (\n                      <jats:italic>Zinc oxide<\/jats:italic>\n                      );\n                      <jats:italic>Sirka (vinegar);<\/jats:italic>\n                      and\n                      <jats:italic>Phitkir\u012b<\/jats:italic>\n                      (\n                      <jats:italic>alum<\/jats:italic>\n                      ) to be applied twice daily for 42\u00a0days. The objective parameters were SCORAD and DLQI, while the subjective parameters included itching, scaling, and erythema assessed on a customized VAS scale and 4-point Likert scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2021-0195_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The pre-post analysis inferred statistically significant attenuation in subjective parameters (itching, scaling, and erythema) and objective scales (SCORAD) and (DLQI) with p&lt;0.001.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2021-0195_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study findings deduced that Marham-e-Akbar is effective in the amelioration of chronic atopic dermatitis and quality of life of the patients as well.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dmpt-2021-0195","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T03:07:02Z","timestamp":1645844822000},"page":"289-294","source":"Crossref","is-referenced-by-count":4,"title":["The efficacy of topical Marham-e-Akbar in chronic atopic dermatitis\u00a0\u2013 an open-label interventional study"],"prefix":"10.1515","volume":"37","author":[{"given":"Shaikh","family":"Imran","sequence":"first","affiliation":[{"name":"Department of Medicine (Unani) , Luqman Unani Medical College Hospital and Research Center , Bijapur , Karnataka , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1928-3744","authenticated-orcid":false,"given":"Mohd","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Medicine (Unani) , Luqman Unani Medical College Hospital and Research Center , Bijapur , Karnataka , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8933-3447","authenticated-orcid":false,"given":"Nazim","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Medicine (Unani) , Luqman Unani Medical College Hospital and Research Center , Bijapur , Karnataka , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Qudrathullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine (Unani) , Luqman Unani Medical College Hospital and Research Center , Bijapur , Karnataka , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalina","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Medicine (Unani) , Luqman Unani Medical College Hospital and Research Center , Bijapur , Karnataka , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"2025121207241450188_j_dmpt-2021-0195_ref_001","doi-asserted-by":"crossref","unstructured":"Jonathan, MS, Paller, AS. 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