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The G1208T polymorphism in the\n                      <jats:italic>CTH<\/jats:italic>\n                      gene, rs1021737, has, in addition to\u00a0\n                      <jats:italic>MTHFR<\/jats:italic>\n                      , been found to increase homocysteine, related to myocardial infarction (MI) risk. This study aimed, for the first time, to investigate the associations of the polymorphisms\n                      <jats:italic>CTH<\/jats:italic>\n                      G1208T,\n                      <jats:italic>MTHFR<\/jats:italic>\n                      C677T, and A1298C with the prospective risk of developing a fatal or non-fatal first MI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2022-0119_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case-referent study included 545 cases later developing a first-ever MI and 1,054 referents from the Northern Sweden Health and Disease Study. Fatal MI was defined as death within 28\u00a0days after MI symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2022-0119_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women, but not men, had a positive association between fatal MI and the\n                      <jats:italic>CTH<\/jats:italic>\n                      G1208T, odds ratio [95% confidence interval] 3.14 [1.16\u20138.54] for heterozygotes, and the dominant model 3.22 [1.22\u20138.51], and for the\n                      <jats:italic>MTHFR<\/jats:italic>\n                      A1298C heterozygotes 3.24 [1.26\u20138.34] and the dominant model 2.63 [1.06\u20136.50]. The\n                      <jats:italic>MTHFR<\/jats:italic>\n                      C677T polymorphism was not related to MI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2022-0119_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study indicates that the minor alleles of\n                      <jats:italic>CTH<\/jats:italic>\n                      G1208T and\n                      <jats:italic>MTHFR<\/jats:italic>\n                      A1298C polymorphisms are associated with a higher risk for a fatal MI among women but not for non-fatal MI. No association was found in men.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dmpt-2022-0119","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T07:38:21Z","timestamp":1666337901000},"page":"57-63","source":"Crossref","is-referenced-by-count":5,"title":["<i>CTH<\/i>\n                    G1208T and\n                    <i>MTHFR<\/i>\n                    A1298C polymorphisms are associated with a higher risk of a first myocardial infarction with fatal outcome among women"],"prefix":"10.1515","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7911-8121","authenticated-orcid":false,"given":"Elisabet","family":"S\u00f6derstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Medical Biosciences, Clinical Chemistry , Norrbotten County Council, Sunderby Hospital, Ume\u00e5 University , Ume\u00e5 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine , Skellefte\u00e5 Research Unit, Ume\u00e5 University , Skellefte\u00e5 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"S\u00f6derberg","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine , Ume\u00e5 University , Ume\u00e5 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethany","family":"van Guelpen","sequence":"additional","affiliation":[{"name":"Department of Radiation Sciences, Oncology , Ume\u00e5 University , Ume\u00e5 , Sweden"},{"name":"Wallenberg Centre for Molecular Medicine, Ume\u00e5 University , Ume\u00e5 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f6rn K.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, Clinical Chemistry , Ume\u00e5 University , Ume\u00e5 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9599-0961","authenticated-orcid":false,"given":"Johan","family":"Hultdin","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, Clinical Chemistry , Ume\u00e5 University , Ume\u00e5 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,10,24]]},"reference":[{"key":"2025121207061399306_j_dmpt-2022-0119_ref_001","doi-asserted-by":"crossref","unstructured":"Zhao, W, Zhang, J, Lu, Y, Wang, R. 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