{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:12:42Z","timestamp":1790957562280,"version":"4.1.0"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dmpt-2024-0088_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>There is an inter-individual in the valsartan response among hypertensive patients. However, clinical factors associated with this variation in the response is still not fully understood. The major purpose of this study is to predict the factors associated with valsartan response and their influence on decreasing blood pressure among patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2024-0088_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is a cross-sectional observational study. It included 91 hypertensive patients on valsartan treatment, selected through simple random sampling from the Jordan University Hospital. The clinical data was collected through documented medical records in the hospital\u2019s computerized system. The data was analyzed using the chi-square test to compare frequencies and categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2024-0088_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients were divided into systolic and diastolic responders. No statistical significance was found between systolic response to valsartan\u2019s and gender, smoking, age, BMI, lipid profile and HbA\n                      <jats:sub>1c<\/jats:sub>\n                      status. Diastolic responders had a positive significance of p-value = 0.006 with BMI categories, however there was no significance with any other factor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2024-0088_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was a better diastolic response to valsartan among hypertensive patients with lower BMI levels. BMI can be considered as a factor to personalize the therapy among patients on valsartan. However, further clinical studies with larger sample size are needed to confirm these data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dmpt-2024-0088","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T19:36:21Z","timestamp":1738784181000},"page":"69-75","source":"Crossref","is-referenced-by-count":1,"title":["Predicting of factors associated with valsartan response among hypertensive patients attending the Jordan University Hospital"],"prefix":"10.1515","volume":"40","author":[{"given":"Shahd","family":"Khalil","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine , Al-Balqa Applied University , Al-Salt , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseel","family":"Quran","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine , Al-Balqa Applied University , Al-Salt , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen","family":"Thalji","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine , Al-Balqa Applied University , Al-Salt , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malk","family":"Al-Adamat","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine , Al-Balqa Applied University , Al-Salt , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Sabha","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine , Al-Balqa Applied University , Al-Salt , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joud","family":"Khraisat","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine , Al-Balqa Applied University , Al-Salt , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel rahman","family":"Al Na\u2019ami","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine , Al-Balqa Applied University , Al-Salt , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Al-Jazzazi","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine , Al-Balqa Applied University , Al-Salt , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Alhawari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine , The University of Jordan , Amman , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazun","family":"Jarrar","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine , Al-Balqa Applied University , Al-Salt , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"2026092515254560568_j_dmpt-2024-0088_ref_001","unstructured":"WHO. 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