{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:20:01Z","timestamp":1784402401962,"version":"3.55.0"},"reference-count":49,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_dmpt-2024-0096_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Primary hypothyroidism is a prevalent endocrine disorder, typically treated with levothyroxine (LT). However, prolonged use of LT may result in complications and suboptimal outcomes for some patients.\n                      <jats:italic>Majoone Sarkhas<\/jats:italic>\n                      (MS), is a polyherbal formulation comprises four plants:\n                      <jats:italic>Commiphora mukul<\/jats:italic>\n                      ,\n                      <jats:italic>Operculina turpethum<\/jats:italic>\n                      ,\n                      <jats:italic>Embelia tseriam-cottam<\/jats:italic>\n                      , and\n                      <jats:italic>Dryopteris filix-mas<\/jats:italic>\n                      . It is traditionally used in Unani medicine for managing hypothyroidism associated conditions. The aim of this study was to assess the synergistic effect of\n                      <jats:italic>Majoone Sarkhas<\/jats:italic>\n                      in combination with LT for the treatment of primary hypothyroidism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2024-0096_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized, single blind, standard clinical trial involved 100 subjects allocated into two groups: an adjuvant treatment group (n=50) and a standard control group (n=50). The adjuvant group received 10\u202fg of MS twice daily in addition LT once daily, while the control group was treated with LT alone once daily. Both groups underwent treatment for 60\u00a0days. Changes in thyroid-stimulating hormone (TSH), free tri-iodothyronine (FT3), and free-thyroxine (FT4) levels from baseline to the 60th day were recorded and analyzed statistically to evaluate the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2024-0096_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study showed adjuvant group (MS\u00a0+\u00a0LT) had more reduction (4.99 vs. 3.93) in serum TSH level in comparison to control group (LT), which was statistically significant (p&lt;0.001), it also showed increase in serum FT3 (2.88\u00a0\u00b1\u00a00.31 vs. 2.97\u00a0\u00b1\u00a00.44) and FT4 (1.06\u00a0\u00b1\u00a00.17 vs. 1.20\u00a0\u00b1\u00a00.27) levels, when compared with baseline values and after completion of trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_dmpt-2024-0096_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The change in thyroid function profiles among adjuvant group, receiving MS with LT in primary hypothyroidism was both clinically and statistically significant. The safety parameters those were followed by serum level of ALT, AST, blood urea and serum creatinine were within the range, indicating the MS is safe medication to be used as an adjuvant therapy with LT (Clinical Trial Registration Code: CTRI\/2018\/02\/011962).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/dmpt-2024-0096","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:23:57Z","timestamp":1740047037000},"page":"121-130","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the add on effect of\n                    <i>Majoone Sarkhas<\/i>\n                    with levothyroxine in primary hypothyroidism: a randomized standard control adjuvant clinical study"],"prefix":"10.1515","volume":"40","author":[{"given":"Md Anzar","family":"Alam","sequence":"first","affiliation":[{"name":"Department of Medicine (Moalajat) , National Institute of Unani Medicine , Bangalore , India"},{"name":"Department of Medicine (Moalaja) , 28848 School of Unani Medical Education and Research (SUMER), Jamia Hamdard , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Aleemuddin","family":"Quamri","sequence":"additional","affiliation":[{"name":"Department of Medicine (Moalajat) , National Institute of Unani Medicine , Bangalore , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulamuddin","family":"Sofi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology (Ilmul Advia) , National Institute of Unani Medicine , Bangalore , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafis","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science , Prince Sultan Military College of Health Sciences , Dhahran , Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"2025121207071569433_j_dmpt-2024-0096_ref_001","doi-asserted-by":"crossref","unstructured":"Taylor, PN, Medici, MM, Hubalewska-Dydejczyk, A, Boelaert, K. 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